A5103253224- Receptor Mechanisms and Signaling
- Cancer Treatment and Pharmacology
- Morinda citrifolia extract uses
- Chemical Synthesis and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Plant biochemistry and biosynthesis
- Microbial Natural Products and Biosynthesis
Agricultural Genomics Institute at Shenzhen
2024
Chinese Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Wilmington University
1997
DuPont (United States)
1997
Paclitaxel is a well known anticancer compound. Its biosynthesis involves the formation of highly functionalized diterpenoid core skeleton (baccatin III) and subsequent assembly phenylisoserinoyl side chain. Despite intensive investigation for half century, complete biosynthetic pathway baccatin III remains unknown. In this work, we identified bifunctional cytochrome P450 enzyme [taxane oxetanase 1 (TOT1)] in
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