A5018006158- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- RNA Interference and Gene Delivery
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Anorectal Disease Treatments and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Pancreatic and Hepatic Oncology Research
- Diverticular Disease and Complications
- HIV Research and Treatment
- Gut microbiota and health
- Cancer Research and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Estrogen and related hormone effects
- IL-33, ST2, and ILC Pathways
- HVDC Systems and Fault Protection
- Peptidase Inhibition and Analysis
- Breast Cancer Treatment Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
The People's Hospital of Guangxi Zhuang Autonomous Region
2018-2024
Jinan University
2024
Nanchang University
2021-2023
First Affiliated Hospital of Jinan University
2023
First Affiliated Hospital of Nanchang University
2021-2023
Academy of Medical Sciences
2023
Guangxi University of Chinese Medicine
2014-2016
Guangxi University
2016
Union Hospital
2014
Huazhong University of Science and Technology
2014
SIVA-1 has been shown to affect apoptotic processes in various different cell lines, and significantly contributes the decreased responsiveness of cancer cells some chemotherapy agents. However, whether potential application gastric remains unknown. Therefore, objective this investigation was clarify distinct function chemotherapeutic drug resistance within a living murine model with malignancy, initially elucidate underlying mechanisms. In an established multidrug-resistant xenograft mouse...
Transcription Factor E2F-1 plays a critical role in cell cycle regulation and other biological processes cells. However whether or not it is involved the multi-drug resistance (MDR) process of gastric cancer has been fully elucidated yet. To explore MDR vitro vivo, cisplatin-resistant line with stable downregulation was established. shRNA led to endogenous mRNA protein. It significantly promoted sensitivity SGC7901/DDP cells cisplatin, doxorubicin, fluorouracil. Flow cytometry confirmed that...
This research investigates the causal relationships among gut microbiota, inflammatory proteins, and bowel disease (IBD), including crohn (CD) ulcerative colitis (UC), identifies role of proteins as potential mediators. Our study analyzed microbiome data from 13,266 samples collected by MiBioGen alliance, along with protein recent Zhao et al, genetic on CD UC International Inflammatory Bowel Disease Genetics Consortium (IIBDGC). We used Mendelian randomization (MR) to explore associations,...
Siva‑1 is a well‑known anti‑apoptosis protein that serves role in multiple types of cancer cells. However, whether affects multidrug resistance via the NF‑κB pathway gastric currently unknown. The present study aimed to determine possible involvement anticancer drug vitro. A vincristine (VCR)‑resistant KATO III/VCR cell line with stable overexpression was established. expression levels Siva‑1, NF‑κB, 1 (MDR1) and (MRP1) were detected western blotting. effect on assessed by measuring 50%...
To elucidate the mechanism by which LINC00174 promotes colon cancer progression targeting microRNA-2467-3p (miR-2467-3p)/enolase 3 (ENO3) axis to regulate inflammation and glycolysis.The expression of ENO3 in tissues, its relationship with survival rate, correlation were analyzed using bioinformatic analysis. The effects overexpression silencing on biological behavior cells via transfection experiments. target relationships between miR-2467-3p or verified sequence prediction dual-luciferase...
SIVA-1 has been reported to play a key role in cell apoptosis and gastric cancer (GC) chemoresistance
Background: Neuroendocrine carcinoma of the breast (NECB) is a rare subtype cancer, comprising only 0.1% to 5% all cancer cases. Despite its rarity, it important gain better understanding epidemiological, clinical, and prognostic features NECB. The purpose study was obtain population-based evaluations epidemiological survival outcomes Methods: data patients with neuroendocrine diagnosed enrolled between 2000 2017 were obtained from Surveillance, Epidemiology, End Results (SEER) database....
Objective: This study was aimed at exploring a specific open region of chromatin in the peripheral blood mononuclear cells (PBMCs) patients with breast cancer and evaluating its feasibility as biomarker for diagnosing predicting prognosis. Methods: We obtained PBMCs from healthy people assay transposase-accessible (ATAC) sequencing (n = 3) GSE27562 chip data secondary analyses. Through bioinformatics analysis, we mined pattern changes accessibility patients. Results: A total 1,906...
This research endeavors to investigate the functions of N6-methyladenosine (m6A) regulatory genes and key linked m6A modifications within context breast cancer (BC). The objective is identify a promising predictive biomarker related validate its significance in BC through experimental methodologies. Utilizing data from Cancer Genome Atlas (TCGA) database, model for predicting prognosis was developed. Key connected were discerned using weighted gene co-expression network analysis (WGCNA)...
Duodenal stump fistula (DSF) is a serious complication of radical gastrectomy for gastric cancer. Herein, we illustrated an innovative choice treating duodenal fistulas by placing modified sump drainage through trocar puncture into the DSF-related abscess (DSF-abscess) cavity. We retrospectively analyzed 974 consecutive patients who underwent cancer between 2011 and 2021. Of these patients, 34 developed postoperative postoperatively were enrolled our study, their clinical data assessed. From...