A5113167246- Sphingolipid Metabolism and Signaling
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Traditional Chinese Medicine Analysis
- Diet, Metabolism, and Disease
- Renal Transplantation Outcomes and Treatments
- Scoliosis diagnosis and treatment
- Neonatal Respiratory Health Research
- Insurance and Financial Risk Management
- Cardiac Ischemia and Reperfusion
- Plant-based Medicinal Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Colorectal Cancer Surgical Treatments
- HIV/AIDS drug development and treatment
- Liver physiology and pathology
- Gut microbiota and health
- FinTech, Crowdfunding, Digital Finance
- Ginseng Biological Effects and Applications
- Infrastructure Resilience and Vulnerability Analysis
- Diet and metabolism studies
- Vagus Nerve Stimulation Research
- Big Data Technologies and Applications
- Drug Transport and Resistance Mechanisms
- Supply Chain Resilience and Risk Management
First Affiliated Hospital of GuangXi Medical University
2023-2025
Nanfang Hospital
2018-2025
Huainan Normal University
2013-2025
Southern Medical University
2018-2025
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine
2025
Guangxi Medical University
2023-2025
Hangzhou Vocational and Technical College
2024
Zoucheng People's Hospital
2024
Capital Medical University
2022
Beijing Chao-Yang Hospital
2022
Radiation enteritis (RE) is a common complication in cancer patients receiving radiotherapy. Although studies have shown the changes of this disease at clinical, pathological and other levels, dynamic characteristics local microbiome metabolomics are hitherto unknown. We aimed to examine multi-omics features gut microecosystem, determining functional correlation between lipid metabolites during RE activity. By delivering single high-dose irradiation, mouse model was established....
Hepatic ischemia/reperfusion injury (HIRI) is a serious complication that occurs following shock and/or liver surgery. Gut microbiota and their metabolites are key upstream modulators of development injury. Herein, we investigated the potential contribution gut microbes to HIRI. Ischemia/reperfusion surgery was performed establish murine model 16S rRNA gene sequencing metabolomics were used for microbial analysis. Transcriptomics proteomics analysis employed study host cell responses. Our...
Background: This study aimed to investigate the potential mechanisms of puerarin in alleviating diabetic nephropathy (DKD) mice. Method: The DKD model was induced by multiple low-dose injections streptozotocin (STZ) and a high-sugar high-fat diet male C57BL/6J After confirming onset DKD, mice were given irbesartan, distilled water, or different concentrations (40 80 mg/kg/d) gavage for 8 weeks. HE staining PAS adopted assess pathological changes kidney tissues. Meanwhile, levels superoxide...
Abstract Bile acid overload critically drives the pathogenesis of cholestatic liver injury (CLI). While ceramide metabolism has garnered increasing interest in research, role ceramides CLI remains unclear. This study investigates function alkaline ceramidase 3 (ACER3)-catalyzed hydrolysis unsaturated CLI. Using clinical specimens, this work finds that ACER3 expression is upregulated and positively correlated with severity patients. Acer3 ablation increases ceramide(d18:1/18:1) attenuates...
The performance evaluation of venture capital in small and medium-sized technology startups involve multiple-attribute group decision-making (MAGDM). To address this challenge, the TODIM MABAC approaches were utilized study. Intuitionistic fuzzy sets (IFSs) employed as a tool to handle uncertainty startups. Building on this, study proposed an intuitionistic TODIM-MABAC (IF-TODIM-MABAC) method solve MAGDM problems under IFSs. Additionally, entropy was applied calculate attribute weight values...
ABSTRACT Resveratrol alleviates liver fibrosis in mice by upregulating IL‐10 to reprogram the macrophage phenotype; however, mechanism remains be elucidated. Building on our previous work, this study, we aimed determine role of TLR2/MyD88/ERK and NF‐κB/NLRP3 inflammasome pathways mediating effects resveratrol polarization. We investigated expression cytokines these a mouse model resveratrol‐treated macrophages. The results showed that TLR2, MyD88, ERK, NF‐κB1 tissues was increased fourth...
Abstract Post-hepatectomy liver dysfunction is a life-threatening morbidity that lacks efficient therapy. Bioactive lipids involved in macrophage polarization crucially regulate tissue injury and regeneration. Herein, we investigate the key bioactive mediate cytotherapeutic potential of polarized-macrophage for post-hepatectomy dysfunction. Untargeted lipidomics identified elevation ceramide (CER) metabolites as signature lipid species relevant to M1/M2 mouse bone-marrow-derived-macrophages...
Overload of palmitic acids is linked to the dysregulation ceramide metabolism in nonalcoholic steatohepatitis (NASH), and ceramides are important bioactive lipids mediating lipotoxicity acid NASH. However, much remains unclear about role ceramidases that catalyze hydrolysis By analyzing National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database, we found alkaline ceramidase 3 (ACER3) upregulated livers patients with Consistently, Acer3 mRNA levels its...
Tea is acknowledged by the U.S. Food and Drug Administration (FDA) as an important functional food, classified 'Generally Recognized Safe' (GRAS). Extensive research conducted over past few decades has demonstrated tea consumption's numerous health benefits through in vitro animal vivo studies. The impact of sex gender differences on outcomes related to consumption been overlooked, resulting errors underestimations that could various outcomes. objective provide a comprehensive overview its...
The machinery that prevents colorectal cancer liver metastasis (CRLM) in the context of regeneration (LR) remains elusive. Ceramide (CER) is a potent anti-cancer lipid involved intercellular interaction. Here, we investigated role CER metabolism mediating interaction between hepatocytes and metastatic (CRC) cells to regulate CRLM LR.Mice were intrasplenically injected with CRC cells. LR was induced by 2/3 partial hepatectomy (PH) mimic LR. alteration corresponding CER-metabolizing genes...
An increasing number of studies on spinal morphology in asymptomatic Asian and Western patients have been reported. Variation anatomy among is considered as the cause wrong-level surgery up to 40% cases. The present study examined rate presence 11 thoracic vertebrae 6 lumbar 293 Chinese adult volunteers.From May 27, 2016, November 11, 2017, a cohort 325 adults meeting exclusion criteria was recruited. radiographs were by spine surgeon radiologist assess vertebrae.In total, volunteers...
In the era of rapid development information, with popularization computers, science and technology, continuous growth IT technology business, enterprise resource planning (ERP) system has become a platform guarantee for completion business management processes after long-term operations. Establishing logistics information is an important means Chinese companies to improve their efficiency. This prerequisite modern gain competitive advantage in companies. Therefore, organizations must adapt...
Abstract Background Lung cancer is a malignant tumour with the fastest increase in morbidity and mortality around world. The clinical treatments available have significant side effects, thus it desirable to identify alternative modalities treat lung cancer. Shashen Maidong decoction (SMD) commonly used traditional Chinese medicine (TCM) formula for treating clinic. While key functional components (KFC) underlying mechanisms of SMD are still unclear. Methods We propose new integrated...
BACKGROUND:The effects of low serum C3 levels and the activation complement system on development prognosis IgAN are unclear. The present study aimed to determine whether decreased influence patients with chronic kidney disease. MATERIAL AND METHODS:We enrolled a total 1564 primary diagnosed by renal biopsy at Chinese PLA General Hospital from January 2011 March 2015. endpoint was end-stage disease (ESRD) or doubling baseline creatinine (D-SCr) level. All were using 1: 1 propensity score...
To evaluate genetic variants affecting mycophenolic acid (MPA) metabolism in Chinese renal transplant recipients.Total 11 SNPs of UGT1A9, UGT1A8, UGT2B7, ABCC2, ABCG2 and SLCO1B3 were genotyped 408 recipients. Associations between MPA concentration/dose ratio (C0/D) analyzed using different models. Multivariate linear regression was used to analyze associations log clinical factors. Results: After adjustment by factors, UGT2B7 rs7662029 associated with a dominant (p = 0.041) an additive...
Compared with single-modal methods, emotion recognition research is increasingly focusing on the use of multi-modal methods to improve accuracy. Despite advantages multimodality, challenges such as feature fusion and redundancy remain. In this study, we propose a multi-label decision system based graph convolution. Our approach utilizes text, speech, video data for extraction, while combining tag attention capture fine-grained modal dependencies. The two-stage reconstruction module...
ABSTRACT Hypoxia-reoxygenation (H/R) injury in steatotic hepatocytes has been implicated liver dysfunction after transplantation. MicroRNAs (miRs) play important roles regulating several cell biology mechanisms related to H/R injury. However, the role of miRs is still unclear. We established an vitro model for studying and identified miR-34a-5p as a miR that was substantially upregulated under challenge. MiR-34a-5p expression modified by transfecting mimic inhibitor into H/R-challenged...
Asiaticoside (AS) displays anti-inflammation, and anti-apoptosis effect, but the role of AS in hyperoxia-induced lung injury (HILI) treatment is undefined. Therefore, aim this study was to investigate effects on HILI premature rats alveolar type II (AEC II) cells. Sprague-Dawley (n=25/group) were exposed 80% O2 with or without AS. Then, we detected O2-induced survival rate rat. We tested concentration malondialdehyde (MDA), myeloperoxidase (MPO), total antioxidant capacity (TAOC), tumor...
The ameliorative effects of α7 nicotinic acetylcholine receptor (α7nAChR) agonists have been demonstrated in acute kidney injury (AKI) caused by multiple stimulations. However, the effect α7nAChR on sepsis-induced (SAKI) cecal ligation and puncture (CLP) model is unclear. Previous studies that highly expressed surface CD4+CD25+ regulatory T cells (Tregs). role Tregs SAKI We hypothesized might play a SAKI. Hence, this study, we determined PNU-282987 (a selective α7nAchR agonist) evaluated...
Abstract Background The relationship between spinal sagittal subtypes and lumbar disc degeneration is unclear. Thus, we aimed to investigate the intervertebral age in asymptomatic healthy individuals with different alignments. Methods In this cross-sectional observational study, examined 209 young middle-aged volunteers (123 women 86 men) who were divided into following three groups according age: A (20–30 years), B (31–40 C (41–50 years). underwent full-spine standing lateral radiography...