A5101637602- Anesthesia and Pain Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Spine and Intervertebral Disc Pathology
- RNA Interference and Gene Delivery
- Alzheimer's disease research and treatments
- Sphingolipid Metabolism and Signaling
- Nausea and vomiting management
- Lipoproteins and Cardiovascular Health
- Cannabis and Cannabinoid Research
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Spinal Hematomas and Complications
- Peroxisome Proliferator-Activated Receptors
- Nitric Oxide and Endothelin Effects
- Immune Response and Inflammation
- Biosensors and Analytical Detection
- Oral Health Pathology and Treatment
- Alcohol Consumption and Health Effects
- Pain Mechanisms and Treatments
- Lipid Membrane Structure and Behavior
- Neuroscience of respiration and sleep
- Neurogenesis and neuroplasticity mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Medicinal Plants and Bioactive Compounds
- Medicinal Plants and Neuroprotection
General Hospital of Guangzhou Military Command
2014-2023
Southern Medical University
2015-2021
Nanfang Hospital
2020-2021
Qilu Hospital of Shandong University
2011
Second Military Medical University
2009
Changhai Hospital
2009
Texas A&M University
2007
Microglial cells are normally activated in response to brain injury or immunological stimuli protect central nervous system (CNS). However, over-activation of microglia conversely amplifies the inflammatory effects and mediates cellular degeneration, leading death neurons. Recently, cordycepin, an active component found Cordyceps militarisa known as a rare Chinese caterpillar fungus, has been reported effective drug for treating diseases cancer via unclear mechanisms. In this study, we...
With the rapid development of aging population, number elderly patients undergoing posterior lumbar spine surgery continues to increase. Lumbar could cause moderate severe postoperative pain, and conventional opioid-based analgesia techniques have many side effects, which are barriers recovery after elderly. Previous studies demonstrated that erector spinae plane block (ESPB) bring about favorable in spinal surgery. As far as concerned, analgesic effects ESPB on not completely clear. This...
The central antihypertensive drug moxonidine lowers blood pressure (BP) through stimulating an imidazoline receptor within the rostral ventrolateral medulla (RVLM). Nitric oxide (NO) generated by inducible NO synthase (iNOS) in RVLM has been suggested to be involved tonic sympathetic inhibition. aim of this study was determine role iNOS mediating moxonidine-induced cardiovascular inhibition rats.In anaesthetized rats, response local or systemic injection observed after treatment with...
Establishing personalized medication plans for patients to maximize therapeutic efficacy and minimize the toxicity of vancomycin (VAN) requires rapid, simple, accurate monitoring VAN concentration in body fluid. In this study, we have developed a simple rapid analytical method by integrating Eu (III) chelate nanoparticles (CN-EUs) lateral flow immunoassay (LFIA) achieve real-time serum within 15 min. This approach was performed on nitrocellulose (NC) membrane assembled LFIA strips via...
Probucol, a lipid-lowering agent with anti-oxidant properties, has been implicated in protection against atherogenesis, whereas its effect on plaques stability remains to be fully elucidated. The present study was aimed test the hypothesis that probucol may attenuate inflammation and increase of vulnerable atherosclerotic using rabbit model. After abdominal aortic balloon injury, 45 rabbits were fed 1% cholesterol diet for 24 weeks. From week 12 24, animals treated (1% by weight diet),...
Background . Reducing β amyloid- (A -) induced microglial activation is considered to be effective in treating Alzheimer’s disease (AD). Nicotine attenuates A -induced activation; the mechanism, however, still elusive. Microglia could activated into classic state (M1 state) or alternative (M2 state); former cytotoxic and latter neurotrophic. In this investigation, we hypothesized that nicotine by shifting M1 M2 state, cannabinoid CB2 receptor protein kinase C mediate process. Methods We used...
Abstract Platelets are critical regulators of liver regeneration, but the mechanisms still not fully understood. have been shown to contain a wide variety microRNAs (miRNAs) and play an important role in many diseases. However, mechanism that how platelet microparticles (PMPs)‐derived miRNA regulate hepatocyte proliferation is very clear. In this study, we successfully isolated identified PMPs. We also found PMPs, which could be well integrated into HHL‐5 cells, upregulate level miR‐25‐3p...
To observe the effect of preemptive local injection ropivocaine with dexmedetomidine on activation glial cells and mirror pain in rats its mechanism.A total 48 adult male Sprague-Dawley (weighing 180 g-220 g) were included study randomized into 3 groups, Group S, R, RD1. A rat model persistent postoperative evoked by skin/muscle incision retraction was established three groups. Before procedures nerve extraction, S (n = 16) injected 0.9% saline locally; R 0.5% locally, RD1 combined 1 μg...
We constructed a water-soluble lipopolymer (WSLP) as nonviral gene carrier to deliver siRNA targeting NR2B. The cytotoxicity and serum stability of WSLP loaded with were evaluated, the knockdown efficiency WSLP/NR2B-siRNA in PC12 cells was examined. results showed that could protect loading siRNAs from enzymatic degradation exhibit low cells. After transfection, complexes reduced NR2B transcriptional level by 50% protein 55% compared control siRNA. Moreover, 3 days after intrathecal...
Objective To evaluate the effect of intraperitoneal water soluble lipopolymer (WSLP)/ N-methyl-D-aspartate receptor subunit 2B (NR2B) siRNA compound on neuropathic pain (NP) in rats.Methods Eighty-four healthy male Sprague-Dawley rats,aged 6 weeks,weighing 180-220 g,were randomly divided into 7 groups (n =12 each) using a random number table:control group (group C),sham operation S),NP group,WSLP/NR2B (siWSLP group),WSLP/negative control (ncWSLP group),PEI/NR2B (PEI group) and WSLP (WSLP...
Objective To explore the analgesic efficacy of dexmedetomidine(Dex) applied with ropivacaine for thoracic paravertebral nerve blockade(TPVB) in thoracotomy. Methods Thirty patients undergoing thoracotomy were randomly divided into two groups(15 each). Patients one group (group TL) received 0.35% 30 ml TPVB, while other ( TDL) 1 μg/kg Dex added TPVB. Thoracic patient-controlled analgesia(PCA) was carried out up till 36 h after surgery. The tenderness thresholds on day before surgery,...