A5100436923- Sphingolipid Metabolism and Signaling
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Lysosomal Storage Disorders Research
- Liver physiology and pathology
- Diet, Metabolism, and Disease
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Neuroendocrine Tumor Research Advances
- Pancreatic function and diabetes
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- Cholesterol and Lipid Metabolism
- Synthesis and biological activity
- Cancer, Lipids, and Metabolism
- Fibroblast Growth Factor Research
- Bacterial Identification and Susceptibility Testing
- COVID-19 Clinical Research Studies
- Lipid metabolism and biosynthesis
- COVID-19 and healthcare impacts
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Biochemical Acid Research Studies
- Peroxisome Proliferator-Activated Receptors
Southern Medical University
2012-2025
Nanfang Hospital
2015-2025
Stony Brook University
2015-2022
Zhujiang Hospital
2021-2022
State University of New York
2015-2022
Abstract Little is known of the patterns expression ACE2 and TMPRSS2 or clinical characteristics COVID-19 in patients with colorectal cancer. We found both bulk single-cell RNA-seq profiles that were expressed at high levels on tumor normal epithelial tissues. Clinically, cancer more likely to have lymphopenia, higher respiratory rate, hypersensitive C-reactive protein than matched but without These results suggest may be particularly susceptible SARS-CoV-2 infection. Further mechanistic...
Dyshomeostasis of both ceramides and sphingosine-1-phosphate (S1P) in the brain has been implicated aging-associated neurodegenerative disorders humans. However, mechanisms that maintain homeostasis these bioactive sphingolipids remain unclear. Mouse alkaline ceramidase 3 (Acer3), which preferentially catalyzes hydrolysis C18:1-ceramide, a major unsaturated long-chain ceramide species brain, is upregulated with age mouse brain. Acer3 knockout causes an age-dependent accumulation various...
Hepatocellular carcinoma (HCC) has been extensively studied as one of the most aggressive tumors worldwide. However, its mortality rate remains high due to ideal diagnosis and treatment strategies. Uncovering novel genes with prognostic significance would shed light on improving HCC patient's outcome. In our study, we applied data-independent acquisition (DIA) quantitative proteomics investigate expression landscape 24 paired patients. A total 1029 differentially expressed proteins (DEPs)...
Radiotherapy stands as a cornerstone in cancer therapy, with nuclear DNA acknowledged the principal target molecule for radiation-induced cellular demise or injury. Nonetheless, an expanding body of contemporary research elucidates significant contri-bution sphingolipids to cell death, particularly modulating apoptosis. Radiation can instigate apoptosis through multiple pathways sphin-golipid metabolism, encompassing activation ceramide synthase, acid sphingomyelin-ase, neutral...
Abstract Bile acid overload critically drives the pathogenesis of cholestatic liver injury (CLI). While ceramide metabolism has garnered increasing interest in research, role ceramides CLI remains unclear. This study investigates function alkaline ceramidase 3 (ACER3)-catalyzed hydrolysis unsaturated CLI. Using clinical specimens, this work finds that ACER3 expression is upregulated and positively correlated with severity patients. Acer3 ablation increases ceramide(d18:1/18:1) attenuates...
Abstract Post-hepatectomy liver dysfunction is a life-threatening morbidity that lacks efficient therapy. Bioactive lipids involved in macrophage polarization crucially regulate tissue injury and regeneration. Herein, we investigate the key bioactive mediate cytotherapeutic potential of polarized-macrophage for post-hepatectomy dysfunction. Untargeted lipidomics identified elevation ceramide (CER) metabolites as signature lipid species relevant to M1/M2 mouse bone-marrow-derived-macrophages...
During diabetic kidney disease (DKD), ectopic ceramide (CER) accumulation in renal tubular epithelial cells (RTECs) is associated with interstitial fibrosis and albuminuria. As RTECs are primarily responsible for energy metabolism, their function intimately linked to mitochondrial quality control. The role of CER synthesis the progression has not been thoroughly investigated. In this study, we observed a significant upregulation synthase 6 (Cers6) expression cortex db/db mice, coinciding...
Overload of palmitic acids is linked to the dysregulation ceramide metabolism in nonalcoholic steatohepatitis (NASH), and ceramides are important bioactive lipids mediating lipotoxicity acid NASH. However, much remains unclear about role ceramidases that catalyze hydrolysis By analyzing National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database, we found alkaline ceramidase 3 (ACER3) upregulated livers patients with Consistently, Acer3 mRNA levels its...
The machinery that prevents colorectal cancer liver metastasis (CRLM) in the context of regeneration (LR) remains elusive. Ceramide (CER) is a potent anti-cancer lipid involved intercellular interaction. Here, we investigated role CER metabolism mediating interaction between hepatocytes and metastatic (CRC) cells to regulate CRLM LR.Mice were intrasplenically injected with CRC cells. LR was induced by 2/3 partial hepatectomy (PH) mimic LR. alteration corresponding CER-metabolizing genes...
Currently, the diagnosis of invasive pulmonary aspergillosis (IPA) mainly depends on integration clinical, radiological and microbiological data. Artificial intelligence (AI) has shown great advantages in dealing with data-rich biological medical challenges, but literature IPA is rare.This study aimed to provide a non-invasive, objective easy-to-use AI approach for early IPA.We generated prototype diagnostic deep learning model (IPA-NET) comprising three interrelated computation modules...
Ceramidases catalyze the cleavage of ceramides into sphingosine and fatty acids. Previously, we reported on use RBM14 fluorogenic ceramide analogs to determine acidic ceramidase activity. In this work, investigated activity other amidohydrolases compounds. Both bacterial human purified neutral ceramidases (NCs), as well ectopically expressed mouse hydrolyzed with different selectivity, depending N-acyl chain length. On hand, microsomes from alkaline (ACER)3 knockdown cells were less...
ABSTRACT Hypoxia-reoxygenation (H/R) injury in steatotic hepatocytes has been implicated liver dysfunction after transplantation. MicroRNAs (miRs) play important roles regulating several cell biology mechanisms related to H/R injury. However, the role of miRs is still unclear. We established an vitro model for studying and identified miR-34a-5p as a miR that was substantially upregulated under challenge. MiR-34a-5p expression modified by transfecting mimic inhibitor into H/R-challenged...
ABSTRACT Long noncoding RNAs have been implicated in many biological processes, but their roles liver regeneration still need to be illustrated. Therefore, we aimed investigate the role of LINC00265 as a pivotal regulator hepatocyte proliferation during regeneration. It was found that is significantly upregulated rat tissues at various time points after 2/3 resection. knockdown inhibited proliferation, induced cell apoptosis and led G2/M phase cycle arrestment. In rats subjected surgery,...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Insolinoma is a rare disease,but with an increased incidence in recent years.From March 2003 to October 2010,16 patients insulinoma had been admitted the Nanfang Hospital,and results of imaging investigation were compared histopathological examination after operation.All cases typical Whipple's triad,low plasma glucose and high insulin concentrations. Sixteen tumors found total.The detection rate ultrasonography was 44％ (7/16),and enhanced computed tomography (CT)and magnetic resonance (MRI)...
Background: Nonalcoholic fatty liver (NAFL) is emerging as a leading risk factor of hepatic ischemia/reperfusion (I/R) injury lacking effective therapy. Lipid dyshomeostasis has been implicated in the hepatopathy NAFL. Herein, we investigate bioactive lipids that critically regulate I/R Methods: Lipidomics were performed to identify dysregulated mouse and human NAFL with injury. The alteration corresponding lipid-metabolizing genes was examined. effects lipid metabolism on evaluated mice...