A5077338429- Nanoparticle-Based Drug Delivery
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Cell death mechanisms and regulation
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Testicular diseases and treatments
- Heat shock proteins research
- ATP Synthase and ATPases Research
- PARP inhibition in cancer therapy
- Sphingolipid Metabolism and Signaling
- Cholesterol and Lipid Metabolism
- Nanomaterials for catalytic reactions
- Elbow and Forearm Trauma Treatment
- Natural Compounds in Disease Treatment
- Liver physiology and pathology
- Ultrasound and Hyperthermia Applications
- Prostate Cancer Diagnosis and Treatment
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Phagocytosis and Immune Regulation
- Advanced Drug Delivery Systems
Southern Medical University
2023-2025
Nanfang Hospital
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking Union Medical College Hospital
2024
Shanghai Children's Hospital
2020-2023
Shanghai Jiao Tong University
2015-2023
RWTH Aachen University
2022
Centre de Recherche en Cancérologie de Marseille
2019-2021
Inserm
2019-2021
Aix-Marseille Université
2019-2021
// Zelai He 1,2 , Jingwen Huang 2 Yuanyuan Xu 3 Xiangyu Zhang Yanwei Teng Can Yufeng Wu 4 Xi Huijun 5 and Wenjie Sun 1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Medical College, University, Shanghai, China The Second Affiliated Hospital Yuying Children's Wenzhou Wenzhou, State Key Laboratory Oncogenes Related Genes, Institute, Renji Hospital, School Medicine, Jiao Tong Internal Zhengzhou Henan Zhengzhou, Cardio-thoracic Surgery, Huashan Correspondence to:...
Intrinsically disordered proteins (IDPs) are emerging as attractive drug targets by virtue of their prevalence in various diseases including cancer. Drug development targeting IDPs is challenging because they have dynamical structure features and conventional design not applicable. NUPR1 an IDP playing important role pancreatic We previously reported that Trifluoperazine (TFP), antipsychotic agent, was capable binding to inhibiting tumors growth. Unfortunately, TFP showed strong central...
Although the treatments of malignant glioma include surgery, radiotherapy and chemotherapy by oral drug administration, prognosis patients with remains very poor. We developed a polyethylene glycol-dipalmitoylphosphatidyle- thanoiamine (mPEG-DPPE) calcium phosphate nanoparticles (NPs) injectable thermoresponsive hydrogel (nanocomposite gel) that could provide sustained local delivery paclitaxel (PTX) temozolomide (TMZ). In addition, proportion PTX TMZ for optimal synergistic antiglioma...
Abstract Ferroptosis is an iron-dependent cell death characterized by the accumulation of hydroperoxided phospholipids. Here, we report that NUPR1 inhibitor ZZW-115 induces ROS followed a ferroptotic death, which could be prevented ferrostatin-1 (Fer-1) and ROS-scavenging agents. The activity can improved inhibiting antioxidant factors in pancreatic ductal adenocarcinoma (PDAC)- hepatocellular carcinoma (HCC)-derived cells. In addition, ZZW-115-treatment increases lipids these We also found...
Establishing the interactome of cancer-associated stress protein Nuclear Protein 1 (NUPR1), we found that it binds to several hundreds proteins, including proteins involved in nuclear translocation, DNA repair, and key factors SUMO pathway. We demonstrated NUPR1 inhibitor ZZW-115, an organic synthetic molecule, competes with importins for binding NLS region NUPR1, thereby inhibiting its translocation. hypothesized, then proved, inhibition by ZZW-115 sensitizes cancer cells damage induced...
Abstract Bile acid overload critically drives the pathogenesis of cholestatic liver injury (CLI). While ceramide metabolism has garnered increasing interest in research, role ceramides CLI remains unclear. This study investigates function alkaline ceramidase 3 (ACER3)-catalyzed hydrolysis unsaturated CLI. Using clinical specimens, this work finds that ACER3 expression is upregulated and positively correlated with severity patients. Acer3 ablation increases ceramide(d18:1/18:1) attenuates...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with almost no curative chemotherapeutic treatment. Besides development new compounds, repurposing approved drugs to treat cancer, alone or in combination, has become an attractive strategy, showing many therapeutic and economic advantages. However, it necessary improve our knowledge about mechanism cell death elicited by itself, but also rationally develop more powerful multidrug treatments. In this work, we focus...
cRGD-targeting matrix metalloproteinase (MMP)-sensitive nanoparticles [PLGA-PEG1K-cRGD/PLGA-peptide-PEG5K (NPs-cRGD)] were successfully developed. Au-Pt(IV) nanoparticles, PTX, and ADR encapsulated into NPs-RGD separately. The effects of the drug-loaded on cell cycle investigated. Here, we showed that higher cytotoxicity was related to arrest, compared free drugs. NPs-cRGD studied here did not disrupt progression. Au-Pt(IV)@NPs-cRGD a main S phase arrest in all phases phase, especially G0/G1...
Triptolide has proven to possess anticancer potential and been widely used for anti-cancer research. However, the liver kidney toxicity limited its application in cancer treatment. In this study, a drug delivery system based on mPEG-DPPE/calcium phosphate was developed co-load triptolide curcumin (TP Curc-NPs). The coefficient of interaction (CDI) calculated determine optimal concentration two drugs. When 25.22 ng/mL 6.62 μg/mL, drugs reached maximum synergistic killing effects SKOV-3 tumor...
Abstract Proteomic, cellular and biochemical analysis of the stress protein NUPR1 reveals that it binds to PARP1 into nucleus inhibits activity in vitro. Mutations on residues Ala33 or Thr68 treatment with its inhibitor ZZW-115 this effect. PARylation induced by 5-fluorouracil (5-FU) is strongly enhanced associated a decrease NAD + /NADH ratio rescued PARP olaparib. Cell death pancreas cancer-derived cells olaparib improved PARG PDD00017273. The mitochondrial catastrophe genetic inactivation...
The machinery that prevents colorectal cancer liver metastasis (CRLM) in the context of regeneration (LR) remains elusive. Ceramide (CER) is a potent anti-cancer lipid involved intercellular interaction. Here, we investigated role CER metabolism mediating interaction between hepatocytes and metastatic (CRC) cells to regulate CRLM LR.Mice were intrasplenically injected with CRC cells. LR was induced by 2/3 partial hepatectomy (PH) mimic LR. alteration corresponding CER-metabolizing genes...
Abstract DNA methylation regulators (DMRs) play a key role in methylation, thus mediating tumor occurrence, metastasis, and immunomodulation. However, the effects of DMRs on clinical outcomes immunotherapy response remain unexplored lung adenocarcinoma (LUAD). In this study, eight LUAD cohorts one immunotherapeutic cohort cancer were utilized. We constructed regulators-related signature (DMRRS) using univariate multivariate COX regression analysis. The DMRRS-defined low-risk group was...
Magnetite loaded Polypeptide‐PLGA multifunctional microbubbles (Fe 3 O 4 /Polypeptide‐PLGA MMBs) that show superparamagnetic properties were prepared by a modified double emulsion method and employed as imaging agent for dual‐mode Ultrasound/Magnetic resonance (US/MR) of prostatic cancer. The successful synthesis MMBs was determined Fourier Transform Infrared Spectrometer (FTIR), X‐ray diffraction (XRD), Transmission Electron Microscope (TEM), Scanning (SEM), Atomic Absorption Spectroscopy...
Overactivation of androgen receptor (AR)-mediated signal has been extensively implicated in prostate cancer (CaP) development, progression, and recurrence, which makes it an attractive therapeutic target. Meanwhile, as endogenous inhibitor histone deacetylase 1 (HDAC 1), tumor-suppressive mammary serine protease (maspin) was reported to sensitize drug-induced apoptosis with a better outcome CaP, but the relationship between AR maspin remains unclear. In current study, treatment 5'-Aza or...
To study bacterial lipopolysaccharide (LPS)-induced cancer stem-like transformation and to investigate the inhibitory effect of Trichostatin A (TSA) on malignant through targeting p-Stat3 signaling.2D, 3D, serum-free suspension culture system were used LPS-induced in series grade prostate (PCa) epithelial cells. Flow cytometry assay RT-PCR utilized evaluate CD44+CD133+ stem cell population, expression inflammatory cytokines tumor stemness biomarkers. Meanwhile, Western blot was analyze...
Introduction: Neuroblastoma (NB) with MYCN amplification has a poor prognosis and high mortality. The potential molecular biological relationship between clinical features should be explored. Methods: NB patients were examined by fluorescence in situ hybridization (FISH) for the tumor mass or bone marrow samples to determine whether was amplified. A series of eleven MYCN-amplified included. age, primary site, size, specific biomarkers, invaded organs analyzed. All accepted standardized...
The aim was to describe the clinical features of extracranial germ cell tumors (GCTs) in pediatrics and study risk factors related survival for malignant (MGCTs) order optimize therapeutic options. data children with GCTs three children's medical centers Shanghai were retrospectively analyzed. In total, 1007 cases diagnosed between 2010 2019 included this study, including teratomas (TERs) 706 (70.11%) MGCTs 301 (29.89%). There twice as many TER MGCT cases. Approximately 50% <3 years old...
Post-hepatectomy liver failure (PHLF) is a fatal complication of hepatectomy. However, the mechanism hepatocyte injury in PHLF remains elusive.