A5081147207- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Histone Deacetylase Inhibitors Research
- Wnt/β-catenin signaling in development and cancer
- Pain Mechanisms and Treatments
- Cancer-related gene regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Cancer-related Molecular Pathways
- Cancer, Stress, Anesthesia, and Immune Response
- CAR-T cell therapy research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Protease and Inhibitor Mechanisms
- Multiple Myeloma Research and Treatments
- Wound Healing and Treatments
- Natural Compounds in Disease Treatment
- Psoriasis: Treatment and Pathogenesis
- Electrospun Nanofibers in Biomedical Applications
- Developmental Biology and Gene Regulation
Guiyang Medical University
2024-2025
Affiliated Hospital of Guizhou Medical University
2024-2025
Jiangsu University
2021-2025
Soochow University
2016-2025
Ruijin Hospital
2023-2024
Shanghai Institute of Hematology
2023-2024
Shanghai Jiao Tong University
2023-2024
Nanjing Medical University
2018-2020
Second Affiliated Hospital of Shantou University Medical College
2018
Shantou University
2018
Background: The neuropathic pain side induced by Vincristine severely limit its clinical application. However, the mechanism of is not clear. This study aims to clarify C/EBP-β regulating TGF-β 1 mediated spinal astrocyte A1/A2 polarization in caused vincristine. Methods: Neuropathic model was established rats intraperitoneal injection (VCR). In vitro experiment, constructed Vincristine, and si-C/EBP-β regulated before VCR administration. Pain threshold measured thermal withdrawal latency...
Tumor cell migration is a critical step in cancer metastasis. Over-activated Notch pathway can promote the of cells, especially breast cancer. However, underlying mechanism non-canonical signaling modulating has not yet been clearly characterized. Here we demonstrated that DAPT, gamma secretase inhibitor, inhibited protrusion formation and motility, then reduced triple-negative through increasing activity Cdc42 by pathway. Phosphorylation AKT on S473 was surprisingly increased when DAPT....
Epidermal growth factor (EGF) has been shown to induce the migration of various cancer cells. However, underlying signaling mechanisms for EGF-induced oral squamous cell carcinoma (OSCC) remain be elucidated. WNT7A, a member family 19 Wnt secreted glycoproteins, is commonly associated with tumor development. It mostly unknown whether and, if so, how EGF modulates WNT7A in OSCC The role was thus investigated explore OSCC.Cell measured by Wound healing assay and Transwell assay. Western...
Summary Third‐generation tyrosine kinase inhibitors (TKIs) have much potential for the treatment of BCR::ABL1 ‐positive leukaemia, particularly that harbouring ABL1 T315I mutation. Olverembatinib (HQP1351), a novel third‐generation TKI, has favourable efficacy and safety profiles in chronic myeloid leukaemia. Here, we present clinical findings from 31 acute lymphoblastic leukaemia (ALL) patients who received olverembatinib. Among 14 with overt relapsed/refractory (R/R) disease (including 10...
Negative-pressure wound therapy (NPWT) is one of the most advanced therapeutic methods in treatment various hard-to-heal acute and refractory chronic wounds. Recent emerging evidence points to a role microRNA-mediated regulation angiogenesis ischemic tissues, series microRNAs associated with have been successively identified. In this study, we found that miR-195 expression was significantly upregulated microvessel density (MVD) increased granulation tissue collected 7 days after NPWT...
// Bing Wang 1, 2 , Hongmei Yong 3 Huijun Zhu 4 Daguang Ni 1 Sijie Tang Shu Zhang Wei Yan Zhou Zhao 5 Guipeng Ding Jin 6 Xiaohua Li 7, 8 Zhenqing Feng 2, 5, 9, 10 Center for Pathology and Laboratory Medicine, Zhangjiagang Ao Yang Hospital, Zhangjiagang, Jiangsu, China Department of Oncology, Huai’an Hospital Affiliated Xuzhou Medical College Second People’s Huai’an, Pathology, Nantong University, Nantong, Nanjing Nanjing, Huadong Institute Biotechniques, 7 School Jiangsu...
Morin can alleviate vincristine-induced neuropathic pain via inhibiting neuroinflammation. Microglial cells play an important role in initiating and maintenance of It remains unclear whether morin exerts antinociceptive properties through the regulation microglial cells. This study aimed to elucidate mechanisms against focusing on
Overactivation of androgen receptor (AR)-mediated signal has been extensively implicated in prostate cancer (CaP) development, progression, and recurrence, which makes it an attractive therapeutic target. Meanwhile, as endogenous inhibitor histone deacetylase 1 (HDAC 1), tumor-suppressive mammary serine protease (maspin) was reported to sensitize drug-induced apoptosis with a better outcome CaP, but the relationship between AR maspin remains unclear. In current study, treatment 5'-Aza or...
DNA methylation is a methyltransferase-mediated epigenetic modification affecting gene expression.This process involved in the initiation and development of malignant disease.5-Aza-2′deoxycytidine (5-Aza), classic methyltransferase inhibitor, possesses antitumor proliferation activity.However, whether 5-Aza induces cytotoxicity solid tumors warrants further investigated.In this study, human prostate cancer (CaP) cells were treated with subjected to cell viability analysis.Reverse...
To study bacterial lipopolysaccharide (LPS)-induced cancer stem-like transformation and to investigate the inhibitory effect of Trichostatin A (TSA) on malignant through targeting p-Stat3 signaling.2D, 3D, serum-free suspension culture system were used LPS-induced in series grade prostate (PCa) epithelial cells. Flow cytometry assay RT-PCR utilized evaluate CD44+CD133+ stem cell population, expression inflammatory cytokines tumor stemness biomarkers. Meanwhile, Western blot was analyze...
Topic: 14. Myeloma and other monoclonal gammopathies - Clinical Background: Extramedullary involvement (or extramedullary disease, EMD) represents an aggressive form of multiple myeloma (MM). Two types EMDs are known to exist: extramedullary‐extraosseous (EM-E) extramedullary‐bone related (EM-B). Although several new EMD treatments available, the prognosis MM patients with remains poor. About 20% newly diagnosed (NDMM) who had at least 1 site impact on outcome in NDMM is influenced by...
Objective To investigate the therapeutic efficacy of trichostatin A (TSA) in combination with Docetaxel (DTX) human prostate cancer chemointervention through studying cytotoxic effect vitro, and possible molecular mechanism. Methods Prostate cells DU145 22Rv1 were treated different doses TSA or DTX respectively. The was evaluated by WST-1 assay. PARP cleavage level phosphorylated H2A.X (p-H2A.X) assessed Western Blot. genes expression tumor suppressive maspin、p21CIP1/WAF1 Bax analyzed...
Abstract Tumorospheres forming assay not only was utilized to enrich cancer stem cell from bulk cells, also widely used analyze the ability of clonogenic growth and self-renewal capability cells. Meanwhile, chronic inflammation-induced epithelial transformation has been documented in a broad range However, effect inflammatory agent on tumorosphere formation never tested. In current study, classic pro-inflammatory lipopolysaccharide establish an vitro model through inducing prostate...