A5101488401- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Retinal Diseases and Treatments
- COVID-19 Clinical Research Studies
- Ocular Surface and Contact Lens
- COVID-19 diagnosis using AI
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Wound Healing and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal and Optic Conditions
- Digital Imaging for Blood Diseases
- Ocular Diseases and Behçet’s Syndrome
- RNA modifications and cancer
- Vascular Malformations Diagnosis and Treatment
- Ocular Infections and Treatments
- Intraocular Surgery and Lenses
- Corneal Surgery and Treatments
- Nasal Surgery and Airway Studies
- Retinopathy of Prematurity Studies
- Nanoplatforms for cancer theranostics
- Polydiacetylene-based materials and applications
The People's Hospital of Guangxi Zhuang Autonomous Region
2020-2024
Affiliated Hospital of Qingdao University
2024
Qingdao University
2017-2024
State Key Laboratory of Ophthalmology
2021
Museum of Heilongjiang Province
2021
The First People's Hospital of Changde
2018-2021
Central South University
2018-2021
Xiangya Hospital Central South University
2021
Sun Yat-sen University
2021
Nankai University
2021
Background As effective medication to treat COVID-19 is currently unavailable, preventive remedies may be particularly important.
Recently, many efforts have been made to build dark energy models whose equation-of-state parameter can cross the so-called phantom divide ${w}_{\mathrm{de}}=\ensuremath{-}1$. One of them is hessence model in which role played by a noncanonical complex scalar field. In this work, we develop simple method based on Hubble $H(z)$ reconstruct energy. As examples, use two familiar parametrizations for and fit latest 182 type Ia supernovae Gold dataset. reconstruction, measurement errors are fully...
Objective: Abnormal proliferation or migration of vascular smooth muscle cells (VSMCs) can lead to vessel lesions, resulting in atherosclerosis and stent-restenosis (IRS). The purpose our study was establish the role miR-378a-5p its targets regulating VSMCs function IRS. Methods: EdU assays Cell Counting Kit-8 (CCK-8) were applied evaluate proliferation, wound healing transwell assess migration. Furthermore, quantitative reverse transcription–polymerase chain reaction (qRT-PCR) performed...
Abstract The objective of this study is to expound the CT features COVID-19 patients whose throat swab samples were negative for two consecutive nucleic acid tests after treatment. We retrospectively reviewed 46 with RT-PCR cases divided into moderate group and severe/critical according disease severity. Clinical scanning data collected. signs pulmonary lesions score lung involvement expounded. Thirty-nine seven included. Residual visible in images. Moderate showed peripheral while exhibited...
Background: Artificial intelligence (AI) has great potential to detect fungal keratitis using in vivo confocal microscopy images, but its clinical value remains unclarified. A major limitation of utility is the lack explainability and interpretability. Methods: An explainable AI (XAI) system based on Gradient-weighted Class Activation Mapping (Grad-CAM) Guided Grad-CAM was established. In this randomized controlled trial, nine ophthalmologists (three expert ophthalmologists, three competent...
Purpose Infiltration of activated dendritic cells and inflammatory in cornea represents an important marker for defining corneal inflammation. Deep transfer learning has presented a promising potential is gaining more importance computer assisted diagnosis. This study aimed to develop deep models automatic detection using vivo confocal microscopy images. Methods A total 3453 images was used train the models. External validation performed on independent test set 558 ground-truth label...
Reactive oxygen species (ROS) overproduction plays an essential role in the etiology of ischemic/hypoxic retinopathy caused by acute glaucoma. NADPH oxidase (NOX) 4 was discovered as one main sources ROS However, and potential mechanisms NOX4 glaucoma have not been fully elucidated. Therefore, current study aims to investigate inhibitor GLX351322 that targets inhibition ocular hypertension (AOH)-induced retinal ischemia/hypoxia injury mice. Herein, highly expressed AOH retinas, particularly...
Negative-pressure wound therapy (NPWT) is one of the most advanced therapeutic methods in treatment various hard-to-heal acute and refractory chronic wounds. Recent emerging evidence points to a role microRNA-mediated regulation angiogenesis ischemic tissues, series microRNAs associated with have been successively identified. In this study, we found that miR-195 expression was significantly upregulated microvessel density (MVD) increased granulation tissue collected 7 days after NPWT...
The findings of this study indicate that adopting a dietary pattern characterized by high levels protein and plant-based foods, as well reduced fat, may offer potential advantages for the prevention AAC.
Purpose: Accurate identification of corneal layers with in vivo confocal microscopy (IVCM) is essential for the correct assessment lesions. This project aims to obtain a reliable automated from IVCM images. Methods: A total 7957 images were included model training and testing. Scanning depth information pixel used build classification system. Firstly, two base classifiers based on convolutional neural networks K-nearest neighbors constructed. Second, hybrid strategies, namely weighted voting...
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Purpose: To assess changes in the choroidal thickness (CT) after macular buckling eyes with high myopia. Methods: Highly myopic that underwent surgery were retrospectively analyzed. Data of swept-source optical coherence tomography scanning at baseline and 1, 3, 6, 12, 18 months collected. Subfoveal CT 750 µ m superior, inferior, nasal, temporal to fovea measured. The total area, vascular stromal area measured by binarization method. vascularity index was calculated dividing area. Results:...
Purpose: Corneal alkali burns (CABs) are a common clinical ocular disease, presenting poor prognosis. Although some long noncoding RNAs (lncRNAs) reportedly play key role in epigenetic regulation associated with CABs, studies regarding the lncRNA signature CABs remain rare and elusive. Methods: A CAB model was established C57BL/6J mice profiling of expressions performed by RNA-Seq. Gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses were conducted to predicate...