A5101866219- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Immune Cell Function and Interaction
- Global Health Care Issues
- Immune cells in cancer
- Intensive Care Unit Cognitive Disorders
- Healthcare Systems and Reforms
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Global Maternal and Child Health
- Invertebrate Immune Response Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Folate and B Vitamins Research
- Obstructive Sleep Apnea Research
- Cardiovascular Health and Risk Factors
- Biotechnology and Related Fields
- Pain Mechanisms and Treatments
- Advanced Glycation End Products research
- Phytochemical compounds biological activities
- GDF15 and Related Biomarkers
- CAR-T cell therapy research
- Sleep and Wakefulness Research
- Anesthesia and Sedative Agents
- Trigeminal Neuralgia and Treatments
Beijing University of Chinese Medicine
2025
Nantong University
2025
Guiyang Medical University
2024
Affiliated Hospital of Guizhou Medical University
2024
Jinan University
2019-2023
St. Jude Children's Research Hospital
2021-2023
Children's Research Hospital
2023
Xi'an Jiaotong University
2016-2021
University of Tennessee Health Science Center
2021
State Administration of Traditional Chinese Medicine of the People's Republic of China
2019
Abstract In this study, we investigated lipopolysaccharide (LPS)-induced cognitive impairment and neuroinflammation in C57BL/6J mice by using behavioral tests, immunofluorescence, enzyme-linked immunosorbent assay (ELISA) Western blot. We found that LPS treatment leads to sickness behavior as shown the Morris water maze passive avoidance test, these effects were accompanied microglia activation (labeled ionized calcium binding adaptor molecule-1, IBA-1) neuronal cell loss...
BACKGROUND: The aim of this study was to investigate the effects esketamine on risk postoperative delirium (POD) in adults undergoing on-pump cardiac valve surgery. METHODS: In randomized, triple-blind, controlled trial, 116 adult patients with an American Society Anesthesiologists (ASA) grade Ⅱ or Ⅲ and a New York Heart Association (NYHA) who underwent surgery cardiopulmonary bypass were included. Esketamine (0.25 mg/kg) normal saline administered intravenously before anesthesia induction....
China has the largest obese population in world, and prevalence of central obesity is increasing dramatically China. Moreover, rapid economic growth recent decades led to urbanization rural However, studies comparing trends different types association with hypertension between urban areas are very scarce, most have focused only on difference overweight general or among populations. Therefore, focus this study was examine shifts overall distribution estimate risk adults aged 18-65 years.Seven...
Luteolin is a flavonoid found in high concentrations celery and green pepper, acts as neuroprotectant. PSMC5 (proteasome 26S subunit, ATPase 5) protein levels were reduced after luteolin stimulation activated microglia. We aimed to determine whether regulating expression could inhibit neuroinflammation, investigate the underlying mechanisms.BV2 microglia transfected with siRNA before addition of LPS (lipopolysaccharide, 1.0 µg/ml) for 24 h serum free DMEM. A mouse model LPS-induced cognitive...
Abstract To investigate the efficacy of laser acupuncture and photobiomodulation therapy in alleviating symptoms among patients diagnosed with Bell’s palsy duration greater than 8 weeks. The randomized controlled trial has been performed from May 2021 to April 2023. Patients were eligible who had weeks on out-patient Department Otorhinolaryngology Beijing Tongren Hospital. group received class IV treatment for 3 times per weeks, a total 72 times. control same procedure except parameter....
Lifestyle choices are important determinants of individual health. Few studies have investigated changes in health behaviors and preventive activities brought about by the 2007 implementation Urban Resident Basic Health Insurance (URBMI) China. This study, therefore, aimed to explore whether URBMI has reduced individuals' incentives adopt healthy utilize care services.Data were drawn from two waves China Nutrition Survey. Respondents categorized according their insurance situation before...
Objective Despite the latest wave of China’s healthcare reform initiated in 2009 has achieved unprecedented progress rural areas, little is known for specific vulnerable groups’ catastrophic health expenditure (CHE) urban China. This study aims to estimate trend incidence, intensity and inequality CHE hypertension households (households with one or more than patient) Shaanxi, China from 2008 2013. Methods Based on fourth fifth National Health Service Surveys we identified 460 1289 2013,...
Chronic disease has become one of the leading causes poverty in China, which posed heavy economic burden on individuals, households and society, accounts for an estimated 80% deaths 70% disability-adjusted life-years lost now China. This study aims to assess effect chronic diseases health payment-induced Shaanxi Province, China.The data was from 5th National Health Survey part China's Service (NHSS) conducted 2013. Totally, 20,700 were selected analysis. We used headcount, gap mean positive...
Morin can alleviate vincristine-induced neuropathic pain via inhibiting neuroinflammation. Microglial cells play an important role in initiating and maintenance of It remains unclear whether morin exerts antinociceptive properties through the regulation microglial cells. This study aimed to elucidate mechanisms against focusing on
This study aims to investigate the difference of pelvic size and shape between Tibetan Chinese Han women. Data on dimension measures including interspinous diameter (IS), intercrestal (IC), external conjugate (EC) transverse outlet (TO) were acquired from two population-based studies amongst women in Lhasa, Shaanxi province China. After coarsened exact matching, there was no statistical any characteristics (p>.05). The generalised estimating equation models showed had significantly lower IS...
Abstract Rationale: Molecular mechanism underlying the autosomal recessive non-syndromic hearing loss (ARNSHL) is still plausible. Pathogenic mutations of gap junction beta 2 protein (GJB2) are reported to be primary causes ARNSHL. Patient concerns: A propositus was diagnosed as ARNSHL with bilateral congenital profound loss. Diagnosis: With microarray and target gene sequencing testing methods, a novel GJB2 mutant found associated in this Han Chinese family. Interventions/Outcomes: Based on...
Abstract Background Luteolin is a flavonoid found in high concentrations celery and green pepper, acts as neuroprotectant. PSMC5 (proteasome 26S subunit, ATPase 5) protein levels were reduced after luteolin stimulation activated microglia. We aimed to determine whether regulating expression could inhibit neuroinflammation, investigate the underlying mechanisms. Methods BV2 microglia transfected with siRNA before addition of LPS (1.0 µg/ml) for 24 h serum free DMEM. A mouse model LPS-induced...
Abstract T cell exhaustion is a major contributor to tumor immune invasion. The durability of an anti-tumor response in part determined by the persistence exhausted CD8 progenitors (Tpex) that reconstitute effector pool. While it has been reported Tpex are able survive without antigen, role TCR engagement regulating self-renewal during progression remains be fully explored. Here, we used Lewis lung carcinoma model where robust or dampened signal was elicited resulting bona fide...