A5080534810- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Flavonoids in Medical Research
- Neurological Disease Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Optical Network Technologies
- Advanced Photonic Communication Systems
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Molecular Communication and Nanonetworks
- Pharmacological Effects of Natural Compounds
- Wireless Body Area Networks
- Endoplasmic Reticulum Stress and Disease
- Dermatology and Skin Diseases
- Computational Drug Discovery Methods
- Inflammasome and immune disorders
- Lipid metabolism and disorders
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Allergic Rhinitis and Sensitization
- Advanced Optical Network Technologies
- Immune Response and Inflammation
- Optical Wireless Communication Technologies
- Energy Harvesting in Wireless Networks
Beijing University of Chinese Medicine
2017-2025
Beijing Institute of Technology
2022-2023
Nanjing University of Posts and Telecommunications
2023
Shanghai Polytechnic University
2016-2017
The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges an ischemic stroke, which promotes neuronal death and inhibits nerve tissue regeneration. As first immune cells to activated microglia play important immunomodulatory role in progression condition. After peripheral blood (mainly T cells) are recruited central nervous system by chemokines secreted brain, where they interact with microglia) trigger a neuroimmune response. This review...
Cerebral ischemia is the second-leading cause of death and main permanent adult disabilities worldwide. Qingkailing (QKL) injection, a patented Chinese medicine approved by China Food Drug Administration, has been widely used in clinical practice to treat cerebral China. The NOD-like receptor pyrin 3 (NLRP3) inflammasome activated thus, an effective therapeutic target. AMP-activated protein kinase (AMPK) important regulator inhibiting NLRP3 activation.We investigated potential QKL injection...
Background: Baicalin (BCL), a candidate drug for ischemic stroke, has been indicated to protect neurons by promoting brain-derived neurotrophic factor (BDNF). However, the cellular source of BDNF release promoted baicalin and its detailed protective mechanism after ischemia/reperfusion remains be studied. The aim this study was investigate neuroprotective mechanisms against oxygen–glucose deprivation/reoxygenation (OGD/R) in neuron–astrocyte coculture system explore whether BDNF-TrkB pathway...
Liver cancer is the fourth leading cause of death worldwide, and hepatocellular carcinoma (HCC) accounts for greatest proportion these deaths. Baicalein, a flavonoid isolated from root Scutellariae radix , considered potential candidate to treat HCC. However, underlying molecular mechanisms remain poorly understood. In present study, network pharmacological approach was combined with microarray data (GSE95504) acquired Gene Expression Omnibus database reveal therapeutic action baicalein at...
Abstract Chronic cerebral hypoperfusion can lead to neuronal necrosis, trigger inflammatory responses, promote white matter damage, and ultimately result in cognitive impairment. Consequently, chronic is an important factor influencing the onset progression of vascular dementia. The myelin sheath a critical component matter, damage repair are closely linked integrity. This article reviews role microglia dementia, focusing on their effects sheaths potential therapeutic implications. findings...
Stroke is the second leading cause of death after heart disease globally and Cerebral ischemic stroke accounts for approximately 70% all incident cases. We selected four main compounds from a patent Chinese medicine, Qingkailing (QKL) injection, including baicalin Scutellariae radix (HuangQin), geniposide Gardeniae fructus (Zhizi), cholic acid hyodeoxycholic Bovis Calculus (Niuhuang) with ratio 4.4:0.4:3:2.6 m/m, to develop more efficacious safer modern medicine refined QKL (RQKL), treat...
Ischemic stroke (IS) can disrupt various types of brain cells in the neurovascular unit (NVU) at both structural and functional levels. Therefore, NVU is considered to be a more comprehensive target for treatment IS. It necessary develop drugs which targeted multiple mechanisms cell on against As component bile acid, cholic acid has been reported able diffuse across phospholipid bilayers further cross blood-brain barrier (BBB). However, effects exerted by (CA) after remain unclear. Based our...
Nonalcoholic fatty liver disease (NAFLD) represents one of the most common forms worldwide, and it is always regarded as a consequence sedentary, food-abundant lifestyle, sitting for an extended time, low physical activity level, which often coincide with chronic long-lasting psychological stress. A Chinese medicine Sinisan (SNS) may be potential formula treating this kind disease. In study, long-term restraint stress protocol was used to investigate mechanism underlying stress-induced...
Background: Accumulating evidence suggests that coronary microvascular dysfunction (CMD) is one of the important causes artery diseases. Angiogenesis can effectively improve CMD by increasing blood supply capacity, recovering cardiac function and poor hemodynamics. Clinical studies have approved Shexiang Tongxin dropping pill (STDP), which has exerted remarkable roles on ameliorating CMD, but effects mechanisms STDPs angiogenesis not been clarified. Purpose: The purpose this study was to...
Endoplasmic reticulum stress (ERS) and autophagy activation play important roles in the process of cerebral ischemia/reperfusion (I/R) injury. The synergistic protective effects Geniposide ursodeoxycholic acid against cellular apoptosis caused by oxygen-glucose deprivation-reoxygenation (OGD/R) were investigated using a Cell Counting Kit-8 assay, lactate dehydrogenase (LDH) flow cytometry, quantitative polymerase chain reaction (qPCR), western blotting to examine viability, apoptosis,...
Free Space Optical (FSO) communication is one of the most promising access methods. But, different weather conditions will affect transceiver performance. In this paper, we build a FSO system with 16-ary phase shift key-orthogonal frequency division multiplexing (16PSK-OFDM) downstream signals. We analyze transmission performance 16PSK-OFDM optical signals under five (sunny, light rain, moderate snow, and fog). The spectral diagrams, constellation bit error rate (BER) received are simulation...
Traditional Chinese medicine (TCM) has a longstanding history and gained widespread clinical applications. San Cao Decoction (SCD) is an experience prescription first formulated by Prof. Duzhou Liu. We previously demonstrated its antihypertensive effects; however, to systematically explain the underlying mechanisms of action, we employed systems pharmacology approach for pharmacokinetic screening target prediction constructing protein-protein interaction networks hypertension-related...
Abstract The eutopic endometrium provides novel insights into endometriotic pathophysiology and treatment. However, no in vivo models currently available are suitable for endometriosis. In this study, we present new associated with using menstrual blood-derived stromal cells (MenSCs). First, isolated MenSCs (E-MenSCs) healthy (H-MenSCs) from the blood of patients endometriosis ( n = 6) volunteers 6). Then, identified MenSCs’ endometrial cell properties adipogenic osteogenic differentiation....
As the charcoal processing product of Scutellariae Radix (SR), SR Carbonisata (SRC) has been clinically used as a cooling blood and hemostatic agent for thousands years. However, underlying active ingredients mechanism SRC still remained unspecified. In this study, derived carbon dots (SRC-CDs) were extracted purified from aqueous solution SRC, followed by physicochemical property assessment series technologies. The effects SRC-CDs further evaluated via blood-heat hemorrhage (BHH) rat model....
Background. Qishen granules (QSG) are a frequently prescribed formula with cardioprotective properties to HF for many years. RNA-seq profiling revealed that regulation on cardiac mitochondrial energy metabolism is the main therapeutic effect. However, underlying mechanism still unknown. In this study, we explored effects of QSG regulating and oxidative stress through PGC-1α/NRF1/TFAM signaling pathway. technology significantly changed differential gene expression dysfunction in myocardial...
To explore the effect of Hupo powder (HP) on autophagy in menstrual blood-derived stem cells (MenSCs) with endometriosis (EMT). EMT MenSCs (E-MenSCs) and healthy (H-MenSCs) were isolated from blood patients female participants, respectively. We identified their cells' characteristics via adipogenic osteogenic differentiation. Twelve male Sprague–Dawley rats received 0.9% NaCl HP-dispensing granules by gastric irrigation to prepare blank serum medicated serum, used concentrations 5%, 10%,...
Non-orthogonal multiple access (NOMA) is viewed as a key technique to improve the spectrum efficiency and solve issue of massive connectivity. However, for power domain NOMA, required overall transmit should be increased rapidly with increasing number users in order ensure that signal-to-interference-plus-noise ratio reaches predefined threshold. In addition, since successive interference cancellation (SIC) adopted, error propagation would become more serious SIC increases. Aiming at...