Carbon dots (CDs) with multifaceted advantages have provided hope for development brand-new nanodrug treating thorny diseases. This study developed a green and simple calcination method to prepare novel CDs as promising drug psoriasis treatment. The as-prepared using Phellodendri Chinensis Cortex (PCC) sole precursor were characterized by series of methods, mainly including electron microscopy, optical technology X-ray photoelectron spectroscopy (XPS).Results displayed that fluorescence...

In this work, we systematically investigated the effect of carbon additions on microstructure and room temperature mechanical properties hot-forged Fe50Mn30Co10Cr10 HEA. The different contents were introduced to Fe50-xMn30Co10Cr10Cx (x = 1, 2.5, 6 at.%, hereinafter, referred as C1, C2.5 C6, respectively) HEAs enhance strength-ductility synergy by triggering multiple strengthening mechanisms. results showed that grain sizes decreased with increasing content, while a high fraction twins ∼45%...

Pollen Typhae Carbonisata (PTC) is a type of calcined herb drug that has been used as hemostatic medicine to promote hemostasis for thousands years. In this study, we discovered and separated novel water-soluble carbon quantum dots (CQDs, named PTC-CQDs) from aqueous extracts PTC. These PTC-CDs were characterized using transmission electron microscopy (TEM) high-resolution TEM, well Fourier transform infrared, ultraviolet–visible, fluorescence spectroscopy. Then, assessed the...

Mulberry silkworm cocoon (MSC) carbonisata has been used for the treatment of inflammatory diseases hundreds years; however, after years research efforts, little information is available on its anti-inflammatory components and underlying mechanism. We developed novel carbon dots (CDs) derived from MSC (MSC-CDs), first time, with an average diameter 2.26-9.35 nm a quantum yield (QY) 6.32%. The MSC-CDs were prepared using modified pyrolysis method, no further modification external surface...

Cerebral infarction and cerebral hemorrhage, also known as "stroke", is one of the leading cause death. At present, there no real specific medicine for stroke. Crinis Carbonisatus (named Xue-yu-tan in Chinese), produced from carbonized hair healthy human, has been widely applied to relieve pain treat epilepsy, stroke other diseases China thousands years.In this work, a new species carbon dots derived (CrCi-CDs) were separated identified. And neuroprotective effect CrCi evaluated using middle...

In this study, a novel NbC reinforced Fe40.5(CoCr)25Mn17.5Ni10Si5 high entropy alloy (HEA) was designed, which exhibits strength and ductility at room temperature. This prepared through hot forging annealing treatments, exhibited the FCC microstructure with discrete nano-sized M23C6 carbides precipitation. The studied HEA retained tensile of 863 MPa, an outstanding 58 %. evolution deformation mechanisms were further investigated. mechanism mainly governed by nano-scale defect heterogeneity...

Aim: To explore the hemostatic effect of Phellodendri Cortex-derived carbon dots. Materials & methods: Transmission electron microscopy, high-resolution transmission Fourier transform infrared spectroscopy, ultraviolet-visible fluorescence x-ray photoelectron spectroscopy and a cell counting kit-8 assay were studied. Hemostatic Cortex Carbonisatus-carbon dots (PCC-CDs) was studied in mouse bleeding models. their related mechanism, coagulation parameters platelets measured. Results: The...

Schizonepetae Herba Carbonisata (SHC) has been used in traditional Chinese medicine (TCM) to treat haemorrhagic diseases for more than 1000 years. However, little information is available on its haemostatic components and mechanism. In this study, we developed novel water-soluble carbon dots (CDs) aqueous extracts of SHC the first time a modified pyrolysis method was prepare using (SH) as sole precursor. The SHC-CDs were characterized transmission electron microscopy (TEM), high-resolution...

To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs).The JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence x-ray photoelectron spectroscopy. The effect was evaluated confirmed by trauma hemorrhagic animal models internal hemorrhage model induced Deinagkistrodon acutus venom.The ranged in diameter from 1.0 to 8 nm had a yield 0.12%. Moreover, not only possessed...

Aim: To explore the antihyperuricemia and anti-gouty arthritis activities of Aurantii fructus immaturus carbonisata-derived carbon dots (AFIC-CDs). Materials & methods: The AFIC-CDs were characterized using transmission electron microscopy; high-resolution ultraviolet, fluorescence, Fourier-transform infrared x-ray photoelectron spectroscopy; high-performance liquid chromatography; diffraction. Antihyperuricemia explored in vivo vitro. Results: diameter ranged from 1.1 to 4.4 nm, with a...

Gout is a disease with high incidence and causing great harm, the current treatment drugs are not satisfactory. In this study, novel water-soluble carbon dots (CDs) anti-gout effect, named Puerariae lobatae Radix CDs (PLR-CDs), reported. PLR-CDs were synthesized an improved pyrolysis method at 300 °C, their characterization was performed multifaceted approaches, such as transmission electron microscopy (TEM) ultraviolet-visible (UV-vis) Fourier-transform infrared (FTIR) spectroscopy....

Aim: To evaluate the analgesic activity of Zingiberis rhizoma-based carbon dots (ZR-CDs). Materials & methods: Novel ZR-CDs were prepared via a facile, green pyrolysis method. Microstructure, optical and functional group properties characterized. Acetic acid writhing, hot-plate tail-immersion tests performed using mice to ZR-CDs, followed by preliminary study on mechanism. Results: with quantum yield 5.2% had diameter ranging from 2.23 3.77 nm. Remarkable effect was observed against both...

A correlation is established between the efficacy of Chinese herbal medicine and its charcoal drugs. Lonicerae japonicae Flos (LJF) commonly used to treat fever, carbuncle, tumors, among others. LJF Carbonisatas (LJFC) preferred for detoxifying relieving dysentery related symptoms. However, mechanisms underlying effects LJFC remain unknown.The aim this study was explore LJFC-derived carbon dots (LJFC-CDs) on lipopolysaccharide (LPS)-induced fever hypothermia rat models.LJFC-CDs were...

Although recent research on intrinsic bioactivities of carbon dots is expanding, it focused basic aspects, which creates the need for broadening our knowledge about to expand their uses in biomedical sciences and facilitate application clinical practice. Jiaosanxian a charcoal traditional Chinese medicine with pronounced effect promoting appetite digestion that widely used as dyspepsia therapy China. To study underlying mechanism material requirements, we investigated was generated...

In this study, for the first time, we discovered novel water-soluble carbon dots (CDs, named CSC-CDs) from aqueous extracts of Cirsium setosum Carbonisata (CSC), which were uniform in size and possessed a nearly spherical shape, CDs exhibited low toxicity against RAW 264.7 cells by CCK-8 assay. Most importantly, tail hemorrhaging liver experiments showed that CSC-CD-treated mice had significantly shorter bleeding times than normal saline-treated mice. Coagulation assays suggested CSC-CDs...

Abstract Background As an emerging nanomaterial, carbon dots (CDs) have been the focus of tremendous attention for biomedical applications. However, little information is available on their bioactivity inhibiting acute kidney injury (AKI) induced by snake venom. Methods This study reports development a green, one-step pyrolysis process to synthesize CDs using Phellodendri Chinensis Cortex (PCC) as sole precursor, and potential application protectant against Deinagkistrodon acutus (D. acutus)...

Introduction: The charcoal processed product of Paeoniae Radix Alba (PRA), PRA Carbonisata (PRAC), has long been used for its hepatoprotective effects. However, the material basis and mechanism action PRAC remain unclear. Aim: To explore effects Carbonisata-derived carbon dots (PRAC-CDs). Methods: PRAC-CDs were characterized using transmission electron microscopy, high-resolution ultraviolet, fluorescence, Fourier transform infrared X-ray photoelectron spectroscopy, diffraction,...

Glycyrrhizae Radix et Rhizoma (GRR) is one of the commonly used traditional Chinese medicines in clinical practice, which has been applied to treat digestive system diseases for hundreds years. GRR preferred anti-gastric ulcer, however, main active compounds are still unknown. In this study, was as precursor synthesize carbon dots (CDs) by a environment-friendly one-step pyrolysis process. GRR-CDs were characterized using transmission electron microscopy, high-resolution TEM, fourier...

Schizonepetae Spica Carbonisata (SSC) has pronounced haemostatic effects for hundreds of years and been acknowledged in the 2015 Pharmacopoeia People's Republic China (PPRC) as a charcoal drug. However, after efforts, underlying mechanism material basis is still less defined. In this research, we developed novel CDs derived from SSC (SSC-CDs) with an average diameter 1.29-6.87 nm quantum yield 6.31%. was prepared using modified pyrolysis method no further modification external surface...