Jiayi Zhao

ORCID: 0000-0002-7258-5867
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Research Areas
  • Immune cells in cancer
  • Geochemistry and Elemental Analysis
  • Immune Response and Inflammation
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Groundwater and Isotope Geochemistry
  • Pelvic floor disorders treatments
  • Pharmacological Effects of Natural Compounds
  • Autophagy in Disease and Therapy
  • Cytokine Signaling Pathways and Interactions
  • Groundwater flow and contamination studies
  • Advanced Glycation End Products research
  • Pain Mechanisms and Treatments
  • Heme Oxygenase-1 and Carbon Monoxide
  • Geothermal Energy Systems and Applications
  • interferon and immune responses
  • Anorectal Disease Treatments and Outcomes
  • Nitric Oxide and Endothelin Effects
  • Phagocytosis and Immune Regulation
  • Heavy Metal Exposure and Toxicity
  • Radioactive element chemistry and processing
  • Calcium signaling and nucleotide metabolism
  • Arsenic contamination and mitigation
  • Toxoplasma gondii Research Studies
  • Evaluation Methods in Various Fields
  • Hereditary Neurological Disorders

Chinese Academy of Geological Sciences
2021-2023

Ministry of Natural Resources
2021-2023

Lyceum of the Philippines University
2023

Wenzhou Medical University
2019-2023

Jinan University
2023

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022

Zhejiang Hospital
2020-2021

Luteolin is a flavonoid found in high concentrations celery and green pepper, acts as neuroprotectant. PSMC5 (proteasome 26S subunit, ATPase 5) protein levels were reduced after luteolin stimulation activated microglia. We aimed to determine whether regulating expression could inhibit neuroinflammation, investigate the underlying mechanisms.BV2 microglia transfected with siRNA before addition of LPS (lipopolysaccharide, 1.0 µg/ml) for 24 h serum free DMEM. A mouse model LPS-induced cognitive...

10.1186/s12974-023-02904-9 article EN cc-by Journal of Neuroinflammation 2023-11-24

The aim of the present study was to further elucidate role JAK2/STAT3-CAV-1-NR2B on painful diabetic neuropathy. In vivo, mechanical withdrawal threshold and thermal latency were measured evaluate neuropathic pain behaviors (n= 8), while western blot 5) an immunofluorescence double staining experiment 6) performed understand molecular mechanism. vitro, individual culture BV2 mouse microglia cell lines, co-culture lines PC12 rat neuron analysis mechanism between neurons. expression p-JAK2,...

10.1007/s12020-019-01880-6 article EN cc-by Endocrine 2019-03-04

Ischaemia-reperfusion (I/R) injury is a major contributor to skin flap necrosis, which presents challenge in achieving satisfactory therapeutic outcomes. Previous studies showed that cathelicidin-BF (BF-30) protects tissues from I/R injury. In this investigation, BF-30 was synthesized and its role mechanism promoting survival of I/R-injured flaps explored.

10.1111/bph.16268 article EN British Journal of Pharmacology 2023-10-18

Abstract The hydrogeochemical characteristics of geothermal fluids can reveal the genesis systems and act as important references for developing using resources. This study presents processes thermal cycle mechanisms typical fields in Western Sichuan. Based on geological conditions Sichuan, 29 hot springs three Batang Litang areas were selected hydrochemical isotopic ( δ D 18 O) analyses. Furthermore, temperature reservoir was calculated upflow cooling process analyzed. Most subterranean...

10.1111/1755-6724.14715 article EN Acta Geologica Sinica - English Edition 2021-03-30

To investigate the protective effect of parecoxib against lung ischemia-reperfusion injury (LIRI) in rats and mechanism.Thirty were divided into sham-operated, LIRI LIRI+parecoxib groups. model (ischemia for 60 min, followed by reperfusion 120 min) was constructed In group, 10 mg/kg given via femoral vein 15 min before ischemia beginning. At end reperfusion, blood gas analysis, wet to dry mass ratio measurement, tissue biochemical determination heme oxygenase-1 (HO-1) protein expression...

10.1590/acb360901 article EN cc-by Acta Cirúrgica Brasileira 2021-01-01

Abstract Background Luteolin is a flavonoid found in high concentrations celery and green pepper, acts as neuroprotectant. PSMC5 (proteasome 26S subunit, ATPase 5) protein levels were reduced after luteolin stimulation activated microglia. We aimed to determine whether regulating expression could inhibit neuroinflammation, investigate the underlying mechanisms. Methods BV2 microglia transfected with siRNA before addition of LPS (1.0 µg/ml) for 24 h serum free DMEM. A mouse model LPS-induced...

10.21203/rs.3.rs-3140879/v1 preprint EN cc-by Research Square (Research Square) 2023-07-07

In recent years, the number of flights in China has been increasing year by year, and more passengers choose airplanes as a means travel. With fierce international domestic market competition among aviation enterprises, have higher requirements for service quality. Therefore, this paper establishes scientific comprehensive evaluation index system gives weight to each index, based on an example, uses fuzzy method comprehensively evaluate current airline passenger satisfaction level. Through...

10.1109/icaml60083.2023.00030 article EN 2023-07-21
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