A5085993491- FOXO transcription factor regulation
- Cytokine Signaling Pathways and Interactions
- Cancer Cells and Metastasis
- Diabetes Treatment and Management
- Renal and Vascular Pathologies
- Autophagy in Disease and Therapy
- Digestive system and related health
- Liver physiology and pathology
- Genetic and Kidney Cyst Diseases
- Sphingolipid Metabolism and Signaling
- Helicobacter pylori-related gastroenterology studies
- Cancer Mechanisms and Therapy
- Renal cell carcinoma treatment
- Pancreatic function and diabetes
Southern Medical University
2020-2025
Nanfang Hospital
2020-2025
Key Laboratory of Guangdong Province
2022
Renal tubulointerstitial fibrosis is considered as an important pathological feature of diabetic kidney disease (DKD). However, the underlying mechanism remains unclear. Polo-like kinase2 (PLK2) a known player in regulation organ fibrosis. Herein, we investigated expression and function PLK2 renal tubular epithelial cells DKD. Data from GSE30529 datasets were subjected to analyze differentially expressed genes (DEGs) non-diabetic tubule samples. Molecular docking analysis Co-IP assay...
Abstract Background cAMP responsive element binding protein 5 (CREB5) is a transcriptional activator in eukaryotic cells that can regulate gene expression. Previously, we found CREB5 was involved the occurrence and development of colorectal cancer (CRC) using bioinformatics analysis. However, biological roles underlying regulatory mechanism CRC remain unclear. Methods Real-time PCR, western blotting, immunohistochemistry were used to examine In vitro experiments including migration assay,...
During diabetic kidney disease (DKD), ectopic ceramide (CER) accumulation in renal tubular epithelial cells (RTECs) is associated with interstitial fibrosis and albuminuria. As RTECs are primarily responsible for energy metabolism, their function intimately linked to mitochondrial quality control. The role of CER synthesis the progression has not been thoroughly investigated. In this study, we observed a significant upregulation synthase 6 (Cers6) expression cortex db/db mice, coinciding...
Forkhead box S1 (FOXS1) is a member of the forkhead (FOX) transcriptional factor superfamily. The biological roles and underlying regulatory mechanism FOXS1 in CRC remain unclear.Bioinformatics analysis, Western blotting, real-time PCR, immunohistochemistry (IHC) were used to detect expression CRC. MTT assay, transwell human umbilical vein endothelial cell tube formation chicken chorioallantoic membrane assay performed investigate effects on proliferation, invasion, angiogenesis....