A5101889964- RNA modifications and cancer
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Immune cells in cancer
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- Thermal Regulation in Medicine
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Peptidase Inhibition and Analysis
- Gut microbiota and health
- Circular RNAs in diseases
- Advanced Materials and Mechanics
- Micro and Nano Robotics
- Dietary Effects on Health
- Inflammasome and immune disorders
- RNA regulation and disease
- Power Transformer Diagnostics and Insulation
- Magnetic Properties and Applications
- Cancer Treatment and Pharmacology
- Advanced biosensing and bioanalysis techniques
- Immune Response and Inflammation
- interferon and immune responses
- Galectins and Cancer Biology
- HER2/EGFR in Cancer Research
Southern Medical University
2018-2025
Sun Yat-sen University
2025
China Pharmaceutical University
2023-2024
Zhejiang University
2022-2024
Southern University of Science and Technology
2024
State Grid Corporation of China (China)
2024
Shenzhen Institutes of Advanced Technology
2024
Chinese Academy of Sciences
2024
Wenzhou Medical University
2024
Northwest A&F University
2017-2023
Sepsis-induced liver injury is recognized as a key problem in intensive care units. The gut microbiota has been touted an important mediator of disease development; however, the precise roles regulating sepsis-induced are unknown. Here, we aimed to investigate role and underlying mechanism. Cecal ligation puncture (CLP) was used induce polymicrobial sepsis related injury. Fecal transplantation (FMT) validate these pathologies. Metabolomics analysis performed characterize metabolic profile...
Sepsis is a life-threatening condition caused by an immune response triggered infection, and highly elevated cytokine/chemokine levels in the blood play crucial roles progression of sepsis. Serum exosomes are nanovesicles that have multiple biological functions, playing antigen presentation, intercellular signal communication, inflammatory surveillance. However, functions related molecular bases remain to be elucidated. In this study, we investigated profiles cytokines/chemokines harbored...
N 6 -methyladenosine (m A) is a fundamentally important RNA modification for gene regulation, whose function achieved through m A readers. However, whether and how readers play regulatory roles during fruit ripening quality formation remains unclear. Here, we characterized SlYTH2 as tomato reader protein profiled the binding sites of at transcriptome-wide level. undergoes liquid–liquid phase separation promotes RNA–protein condensate formation. The target mRNAs SlYTH2, namely A-modified...
Hepatic ischemia/reperfusion injury (HIRI) is a serious complication that occurs following shock and/or liver surgery. Gut microbiota and their metabolites are key upstream modulators of development injury. Herein, we investigated the potential contribution gut microbes to HIRI. Ischemia/reperfusion surgery was performed establish murine model 16S rRNA gene sequencing metabolomics were used for microbial analysis. Transcriptomics proteomics analysis employed study host cell responses. Our...
Acute liver failure is characterized by the rapid development of dysfunction and remarkably high mortality. Accumulating evidence suggests that soyasaponin possesses potential anti-inflammatory activities. Here, we aimed to investigate role II in acute establish underlying mechanism.
Studying different types of DNA damage induced by ultra-high-dose-rate (UHDR) irradiation is essential for understanding the mechanism underlying FLASH effect. pBR322 plasmid was irradiated using an electron beam. The content each subtype measured via gel electrophoresis, and extent double-strand breaks (DSBs) single-strand (SSBs) under UHDR conventional-dose-rate (CONV) quantitatively compared. Furthermore, adding endonucleases Nth Fpg, base in CONV group analyzed. In addition, effects...
Sepsis is an infection-induced severe inflammatory disorder leading to multiple organ dysfunction. It remains a highly lethal condition for which early diagnosis and therapy achieve unsatisfactory results. Circulating exosomes containing biomarkers mediators of sepsis have recently received attention, but the progress has been far from optimal. The present study focuses on profiles molecular dynamics in serum explores potential mechanisms during process sepsis. We used high-performance...
Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) is a highly attractive therapeutic target for treating Kirsten rat sarcoma viral oncogene (KRAS) mutant cancers. In this work, series of guanidine-based SHP2 allosteric inhibitors were discovered via virtual screening and rational structural optimization. Notably, lead compound 23 with potent inhibitory activity (IC50 = 17.7 nM) effectively inhibited the proliferation, migration, invasion MIA PaCa-2 pancreatic cancer...
The integration of RNA metabolic labelling by nucleoside analogues with high-throughput sequencing has been harnessed to study dynamics. immunoprecipitation purification or chemical pulldown technique is generally required enrich the analogue-labelled RNAs. Here we developed an a
Long noncoding RNAs (lncRNAs), once thought to be transcriptional noise, have been recently shown regulate a variety of biological processes. However, their roles in the inflammatory response are largely unexplored. In this study, we performed high-throughput sequencing identify profiles mRNA and lncRNA transcriptomes lipopolysaccharide (LPS) stimulation, followed by comprehensive bioinformatics analysis. We found total 325 lncRNAs 1,187 mRNAs significantly dysregulated RAW264.7 cells...
Abstract Effectively killing pathogenic bacteria is key for the treatment of sepsis. Although various anti-infective drugs have been used sepsis, therapeutic effect largely limited by lack a specific bacterium-targeting delivery system. This study aimed to develop antibacterial peptides that specifically target The lethal bacterial strain Escherichia coli MSI001 was isolated from mice cecal ligation and puncture (CLP) model as screen binding heptapeptides through an integrative...
<h2>Summary</h2> Aneurysm is a common disease that poses threat to human health. Currently, treating aneurysms mainly relies on embolization using metallic microcoils. However, it extremely difficult insert microcoils into the aneurysm inside tortuous vessels. Besides, adapting fixed different also major problem. In this paper, we propose shape-programmable robot based magnetic and radio frequency (RF) dual-responsive shape memory polymer (SMP). The SMP can move automatically target under...
Abstract Understanding of the molecular regulatory mechanisms underlying inflammatory response is incomplete. The present study focuses on characterizing proteome in a model inflammation macrophages treated with lipopolysaccharide (LPS). A total 3597 proteins are identified data‐independent acquisition (DIA) method. Bioinformatic analyses reveal discrete modules and mechanisms, as well signaling network that modulates development inflammation. It found 87 differentially expressed shared by...
To elucidate the transcriptome of macrophages in an inflammation model induced by lipopolysaccharide (LPS), providing insight into molecular basis inflammation.
ABSTRACT Genomic imprinting is essential for mammalian development. PGC7, an important maternal factor, binds to dimethylated histone H3K9 (H3K9me2), maintaining DNA methylation in zygotes and stem cells. However, the underlying molecular mechanisms of PGC7‐maintained genomic cells are not clear. Our previous study has identified that PGC7 interacts with HP1BP3, a novel member H1 family. In this study, we found central globular domain HP1BP3 through its C‐terminal tail responsible...
DNA methylation is an important epigenetic modification that needs to be carefully controlled as a prerequisite for normal early embryogenesis. Compelling evidence now suggests four maternal-effect proteins, primordial germ cell 7 (PGC7), zinc finger protein 57 (ZFP57), tripartite motif-containing 28 (TRIM28) and methyltransferase (cytosine-5) 1 (DNMT1) are involved in the maintenance of methylation. However, it still not fully understood how these proteins maintain imprint. We noticed...
Primordial germ cell 7 (PGC7), a maternal factor essential for early development, plays critical role in the regulation of DNA methylation, transcriptional repression, chromatin condensation, and division maintenance pluripotentiality. Despite fundamental roles PGC7 these cellular processes, only few molecular functional interactions have been reported. Here, streptavidin-biotin affinity purification technique combined with LC-MS/MS was used to analyze potential proteins that interact PGC7....
Purpose: Our aim was to elucidate the critical factors responsible for inducing FLASH effect, focusing on role of free radicals through simulation and experimental approaches. Methods Materials: The whole abdomen C57BL/6 mice irradiated with 6 MeV electron beam. endpoint acute intestinal toxicity quantified by histological score. Total doses ranging from 15 Gy were evaluated. impact mean dose rate (MDR) assessed in range 40 900 Gy/s. Dose per pulse (DPP) 0.5 3 compared. recombination peroxyl...
The hot spot temperature of an oil-immersed transformer is a critical indicator its service life and operational performance. In this study, detailed examination 66kV naturally cooled conducted by establishing two-dimensional physical model simulating the transient field under natural oil circulation conditions using finite element software. This analysis primarily focuses on rise from initial moment until thermal equilibrium reached, providing insights into dynamics transformer....
Primordial germ cell 7 (PGC7)(Dppa3 or Stella) is a small inherently disordered protein that mainly expressed in oocytes and plays vital role the regulation of DNA methylation reprogramming imprinted loci through interaction with other proteins. Most PGC7-deficient zygotes are blocked at two-cell stage an increased tri-methylation lysine 27 histone H3 (H3K27me3) level nucleus. Our previous work has indicated PGC7 interacts yin-yang1 (YY1) essential for recruitment enhancer zeste homolog 2...