A5100698020- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Spinal Fractures and Fixation Techniques
- Herpesvirus Infections and Treatments
- Animal Disease Management and Epidemiology
- Rabies epidemiology and control
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Ferroptosis and cancer prognosis
- Bat Biology and Ecology Studies
- Viral Infections and Outbreaks Research
- Muscle Physiology and Disorders
- Vector-borne infectious diseases
- Pelvic and Acetabular Injuries
- Fuel Cells and Related Materials
- Plant Virus Research Studies
- Fungal Biology and Applications
- Liver Disease Diagnosis and Treatment
Chinese Academy of Sciences
2005-2025
Second Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Northwest A&F University
2025
Changchun Institute of Applied Chemistry
2025
State Key Laboratory of Rare Earth Resources Utilization
2025
Hubei Academy of Agricultural Sciences
2017-2024
Animal Science Research Institute
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2023
Huazhong Agricultural University
2021-2022
H5N1 avian influenza virus (AIV) has emerged as a pathogenic entity for variety of species, including humans, in recent years. Here we report an outbreak among migratory birds on Lake Qinghaihu, China, May and June 2005, which more than thousand were affected. Pancreatic necrosis abnormal neurological symptoms the major clinical features. Sequencing complete genomes four AIV strains revealed them to be reassortants related peregrine falcon isolate from Hong Kong have known highly...
Significance Optimal cell delivery strategies are in urgent need to enhance the specificity, efficacy, and reproducibility of therapy leading minimized dosage side effects. Here, we addressed this unmet by developing injectable 3D microscale cellular niches (microniches) based on biocompatible biodegradable gelatin microcryogels. Dramatic improvement retention, survival, therapeutic effects enabled primed microniches was demonstrated treatment critical limb ischemia (CLI) mouse models...
Developing an active and durable acidic oxygen evolution reaction (OER) catalyst is vital for implementing proton exchange membrane water electrolyzer (PEMWE) in sustainable hydrogen production. However, it remains dauntingly challenging to balance high activity long‐term stability under harsh oxidizing conditions. Herein, through developing the universal rare‐earth participated pyrolysis‐leaching approach, we customized long lifespan pseudo‐amorphous IrOx with locally ordered rutile IrO2...
Developing an active and durable acidic oxygen evolution reaction (OER) catalyst is vital for implementing proton exchange membrane water electrolyzer (PEMWE) in sustainable hydrogen production. However, it remains dauntingly challenging to balance high activity long‐term stability under harsh oxidizing conditions. Herein, through developing the universal rare‐earth participated pyrolysis‐leaching approach, we customized long lifespan pseudo‐amorphous IrOx with locally ordered rutile IrO2...
DNA methylation has emerged as a crucial regulator of chondrocyte dedifferentiation, which severely compromises the outcome autologous implantation (ACI) treatment for cartilage defects. However, full-scale profiling in dedifferentiation remains to be determined. Here, we performed genome-wide dedifferentiated chondrocytes monolayer culture and treated with inhibitor 5-azacytidine (5-AzaC). This research revealed that general level CpG was increased while COL-1A1 promoter decreased during...
Tat is a multifunctional transactivator encoded by human immunodeficiency virus type 1 (HIV-1). transactivating activity controlled nicotinamide adenine nucleotide(+) (NAD(+))-dependent deacetylase sirtuin (SIRT1). Nicotinamide phosphoribosyltransferase (Nampt) rate-limiting enzyme in the conversion of into NAD(+), which crucial for SIRT1 activation. Thus, effect Nampt on Tat-regulated SIRT was studied Hela-CD4-beta-gal (MAGI) cells. We demonstrated that caused NAD(+) depletion and inhibited...
Background High-density porous polyethylene (Medpor) has long been used in cranioplasty and is still one of the best materials for calvarial reconstruction. Calvarial defects can be effectively reconstructed with fewer complications by using Medpor. This article reports our study on use Medpor reconstructing defects. Methods Twenty-three patients who underwent from 1999 to 2011 were included this study. In all patients, was defect reconstruction, followed up at least 6 months. Results Most...
Summary Recent studies show that variants in some interferon genes together with receptor are associated the outcome of infectious diseases. We examined association between risk hepatitis B virus ( HBV )‐related liver disease and functional polymorphisms within IFNL 4, IFNLR 1 , IFNA 1, 2, 5 IFNAR 2 (14 loci all) a Han Chinese population. A total 3128 people participated were divided into groups: healthy controls, natural clearance, chronic B( CHB ), cirrhosis hepatocellular carcinoma HCC )....
Multidrug resistance protein 4 (MRP4) has been associated with nucleos(t)ide analogue (NA) antiretroviral therapy failure, though is unclear if MRP4 also correlated the failure of anti-hepatitis B virus (HBV) therapy.Multidrug expression in human peripheral blood mononuclear cells (PBMCs), liver tissues and hepatoma cell lines was detected by real-time polymerase chain reaction (PCR), western blotting immunohistochemistry assays. Supernatant intracellular HBV DNA levels MRP4-overexpressing...
The outbreak and pandemic of COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has developed into a public health emergency international concern. rapid accurate detection the virus is critical means to prevent control disease. Herein, we provide novel, rapid, simple approach, named dual reverse transcriptional colorimetric loop-mediated isothermal amplification (dRT-cLAMP) assay, accelerate SARS-CoV-2 without using expensive equipment. result this assay shown...
Outbreaks of highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) have led to large economic losses in China. The attenuated vaccine (HP-PRRSV JXA1-R) was used control HP-PRRSV. However, recent years, co-infection with classical PRRSV (C-PRRSV), HP-PRRSV, and/or HP-PRRSV JXA1-R has been increasing China, resulting a significant impact on diagnostics management. To facilitate rapid discrimination from C-PRRSV, multiplex RT-PCR assay for the visual detection JXA1-R,...
Background Various kinds of grafts, such as autogenous bone grafts and alloplastic materials, can be used for the reconstruction calvarial defects. The selection optimum material repair cranial defects is greatest problem in For some complex defects, simple use or materials makes functional cosmetic difficult to achieve. Therefore, current study uses a new method Methods Eight patients with underwent cranioplasty porous polyethylene combined split graft. Follow-up visits were conducted 6 72...
Dengue fever is a mosquito-borne viral disease with dramatically increasing morbidity rate worldwide in decades. Since there no specific treatment to date, early diagnosis important for providing proper timely medical care minimize mortality, and the prompt initiation of public health control measures. NS5 potential biomarker dengue virus infection due its highly conserved immunogenic properties. In this study, DENV 2 full-length C-terminus RNA-dependent RNA polymerase domain fragment...
Bovine parvovirus (BPV), bovine coronavirus (BCoV) and parainfluenza virus (BPIV) are common etiologies causing gastrointestinal respiratory diseases in dairy herds.However, there few reports on the synchronous detection of BPV, BCoV BPIV.The present article aimed to develop a quick accurate RT-PCR assay synchronously detect BPIV based their specific probes.One pair universal primers, one primers probe was designed synthesized.After concentrations primer annealing temperature were strictly...
Objective: This research aimed to make comparisons of sensitivity and specificity between Quantitative real Time Polymerase Chain Reaction (Q-PCR) Reverse Transcription PCR (RT-PCR) in detecting the ribonucleic acid (RNA) expression levels Hepatitis C Virus (HCV). Methods: 121 patients suffering from hepatitis 98 healthy participants with normal liver functions were identified. The venous blood collections carried out, subjected detect HCV RNA via Q-PCR RT-PCR. And then, data obtained these...