A5100990641- Radiopharmaceutical Chemistry and Applications
- Peptidase Inhibition and Analysis
- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Cardiac Structural Anomalies and Repair
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Chemotherapy-induced cardiotoxicity and mitigation
- Cell Adhesion Molecules Research
- Lung Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Effects of Radiation Exposure
- Nanoplatforms for cancer theranostics
- Endometrial and Cervical Cancer Treatments
- Spectroscopy and Chemometric Analyses
- Advanced Nanomaterials in Catalysis
- Remote Sensing in Agriculture
- S100 Proteins and Annexins
- Nanoparticle-Based Drug Delivery
- Cardiac Imaging and Diagnostics
- Acute Myeloid Leukemia Research
- Medical Imaging and Pathology Studies
- Ovarian cancer diagnosis and treatment
Shandong Tumor Hospital
2015-2025
Shandong First Medical University
2015-2025
University of Southern California
2023-2024
Shandong University
2016-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Academy of Medical Sciences
2022
Nanjing Normal University
2022
Dezhou University
2021
Shangqiu First People's Hospital
2021
Chung Yuan Christian University
2021
Background The radiotracer fluorine 18 (18F)–labeled fibroblast activation protein inhibitor (FAPI) has shown promise for visualizing several types of cancer, but the accuracy 18F-FAPI compared with 18F-fluorodeoxyglucose (FDG) detection lung cancer remains uncertain. Purpose To evaluate effectiveness 18F-FAPI–based PET/CT imaging diagnosis primary and metastatic lesions as 18F-FDG PET/CT. Materials Methods In this secondary analysis a prospective trial, consecutively recruited patients from...
Heterogeneity is found in the tumor microenvironment among different pathological types of tumors. Radionuclide-labeled fibroblast-activation-protein inhibitor (FAPI), as an important tracer for non-invasive imaging microenvironment, can be used to evaluate expression FAP cancer-associated fibroblasts, macrophages, and cells. Our aim was explore ability [18F]AlF-NOTA-FAPI-04 positron emission tomography (PET)/computed (CT) distinguish lung cancer by evaluating uptake this primary metastatic...
Background The coexistence of lung cancer and pulmonary tuberculosis (TB) makes differential diagnosis even more complicated. purpose the study is to explore superiority [ 18 F]-NOTA-FAPI-04 PET/CT in distinguishing TB from malignant lesions accurately detecting inflammatory lymph nodes than F]-FDG PET/CT. Case summary Herein, we described a case report patient with both underwent Al[ positron emission tomography/computed tomography (PET/CT) determine staging. Additionally, literature review...
This prospective study examined whether imaging results obtained using the tracer <sup>18</sup>F-AlF-NOTA-fibroblast activation protein inhibitor (FAPI)-04 (denoted as <sup>18</sup>F-FAPI-04) in PET/CT can predict short-term outcome patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC) treated concurrent chemoradiotherapy (CCRT). <b>Methods:</b> The 18 enrolled LA-ESCC underwent <sup>18</sup>F-FAPI-04 scanning before CCRT. SUV<sub>max</sub>, SUV<sub>mean</sub>,...
Clinical radiotherapy (RT) is severely limited by hypoxic tumor microenvironment and a lack of targeting precision. Therefore, it crucial to develop highly efficient radiosensitizers enhance RT efficacy. Herein, novel kind epidermal growth factor receptor (EGFR)-antagonistic affibody-functionalized Pt-based nanozyme for sensitization EGFR-positive tumors was developed. In this study, porous platinum nanoparticles (pPt NPs) featuring catalase (CAT)-like activity strong radiation energy...
Purpose This is a clinical study to compare noninvasive hypoxia imaging using 18F-fluoroerythronitroimidazole (18F-FETNIM) and 18F-fluoromisonidazole (18F-FMISO) positron emission tomography/computed tomography (PET/CT) in patients with inoperable stages III–IV lung cancer. Methods A total of forty-two cancer underwent 18F-FETNIM PET/CT (n = 18) 18F-FMISO 24) before chemo/radiation therapy. The standard uptake values (SUVs) malignant normal tissues depict uptake. Tumor-to-blood ratios (T/B)...
This single-center, single-arm, phase II trial (ChiCTR2100050057) investigated the ability of
Cardiotoxicity is a well-recognized, serious adverse effect of thoracic radiation therapy. This study aimed to evaluate longitudinal electrocardiogram (ECG) changes in patients receiving therapy and identify correlating factors that can predict the risk cardiotoxicity. retrospective included 202 treated with therapy, chemotherapy targeted were allowed. Mean heart dose (MHD) was evaluated on dose-volume histograms. ECG, high-sensitivity cardiac troponin T (hs-cTnT), N-terminal B-type...
Neoadjuvant therapy modality can increase the operability rate and mitigate pathological risks in locally advanced cervical cancer, but treatment response varies widely. It remains unclear whether genetic alterations correlate with to neoadjuvant disease-free survival (DFS) cancer.
Abstract As nanotechnology rapidly advances, siliceous nanomaterials have become increasingly examined for biomedical applications. To further expand their advantageous physicochemical properties and counter intrinsic limitations challenging progress toward clinical translation, strategies ranging from new fabrication methods to diverse forms of modifications been proposed. Among them, direct incorporation foreign species into the frameworks has emerged. The inorganic or organic moieties an...
There is no sensitive and effective method to predict radiation-induced myocardial damage (RIMD). The aim of this study was explore plasma biomarkers for early prediction RIMD after radiotherapy (RT) in lung cancer patients a rat model. Biomarker levels were measured samples collected before thoracic RT from 17 patients. For the animal model, single radiation dose 40 Gy delivered cardiac apex female Wistar rats. Control rats received sham irradiation (0 Gy). Dynamic biomarker detection...
The study investigated the predictive value of tumor angiogenesis observed by 18F-ALF-NOTA-PRGD2 II (denoted as 18F-Alfatide II) positron emission tomography (PET)/computed (CT) before concurrent chemoradiotherapy (CCRT) for treatment response and survival among patients with locally advanced non-small cell lung cancer (LA-NSCLC).Patients unresectable stage IIIA or IIIB NSCLC (AJCC Cancer Staging 7th Edition) who received CCRT were included in this prospective study. All had undergone PET/CT...
In this study, we explore the diagnostic value of a novel PET/CT imaging tracer that specifically targets fibroblast activation protein (FAP), 18F-NOTA-FAPI, in radiation induced lung damage (RILD) rat model. High focal (40, 60, or 90 Gy) was administered to 5-mm diameter area right Wistar rats for evaluation RILD induction. Lung tissues exposed Gy were scanned with 18F-NOTA-FAPI and 18F-FDG. Dynamic scanning performed on day 42 post-irradiation. After vivo scanning, cryosections prepared...
Background Allogeneic hematopoietic stem cell transplant remains the most effective strategy for patients with high-risk acute myeloid leukemia (AML). Leukemia-specific neoantigens presented by major histocompatibility complexes (MHCs) are recognized T receptors (TCR) triggering graft-versus-leukemia effect. A unique TCR signature is generated a complex V(D)J rearrangement process to form capable of binding peptide-MHC. The repertoire undergoes dynamic changes disease progression and...