Abstract BACKGROUND Metarhizium anisopliae and Beauveria bassiana mainly infect insects through the cuticle; gut infection occasionally occurs. Micro‐organisms existing in may play a crucial role evolution ecology of host defenses against fungal pathogens. To evaluate whether bacteria participate antifungal activity, to determine their protection, interactions between M. diversity microbiota cockroaches were studied. RESULTS An oral feeding test showed that mortality conventional was...

Background The radiotracer fluorine 18 (18F)–labeled fibroblast activation protein inhibitor (FAPI) has shown promise for visualizing several types of cancer, but the accuracy 18F-FAPI compared with 18F-fluorodeoxyglucose (FDG) detection lung cancer remains uncertain. Purpose To evaluate effectiveness 18F-FAPI–based PET/CT imaging diagnosis primary and metastatic lesions as 18F-FDG PET/CT. Materials Methods In this secondary analysis a prospective trial, consecutively recruited patients from...

Abstract Irreversible damage to hair cells (HCs) in the cochlea leads hearing loss. Cochlear supporting (SCs) murine have potential differentiate into HCs. Neuron membrane glycoprotein M6B ( Gpm6b ) as a four‐transmembrane protein is regulator of HC regeneration according our previous research. In this study, we found that AAV‐ie‐mediated overexpression promoted SC‐derived organoid expansion. Enhanced prevented normal decrease SC plasticity develops by re‐entry cell cycle and facilitating...

We present an efficient, easy-to-use chromatographic method to separate reactive and nonreactive sulfur compounds in crude oil for subsequent quantitative analysis molecular characterization. Sulfur petroleum samples are separated by ligand exchange chromatography (LEC) on a silver-modified strong-cation (SCX) solid-phase extraction (SPE) cartridge. LEC separation takes advantage of the bonding affinity different types with silver-cations. The elution particular type (reactive or...

Gulf of Mexico saltmarsh sediments were heavily impacted by Macondo well oil (MWO) released from the 2010 Deepwater Horizon (DWH) spill. Detailed molecular-level characterization sediment extracts collected over 48 months post-spill highlights chemical complexity highly polar, oxygen-containing compounds that remain environmentally persistent. Electrospray ionization (ESI) Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS), combined with chromatographic prefractionation,...

<i>Salviae miltiorrhiza</i>, a traditional Chinese medical herb known as "Danshen," has been widely used in clinics to improve blood circulation, relieve stasis, and treat coronary heart disease. Depside salts from <i>S. miltiorrhiza</i> are novel drug which magnesium lithospermate B its analogs the active components. The pharmacokinetics, tissue distribution, metabolism, excretion of three major components, lithospermic acid B, rosmarinic (RA), (LA), were studied by liquid...

An atypical distribution of steroids occurred in oilsand and oil samples the Jinxian Sag, Bohai Bay Basin, northern China. It is featured by usually abundant C21–C26 short-chain steranes that are derived from cleavage weak C–S bonds at C-17 C-20 positions. Sulfur-containing petroleum biomarkers were further analyzed these sulfur-rich heavy oils comprehensive two-dimensional gas chromatography (GC × GC) using sulfur-specific detection to locate confirm sulfur species GC time-of-flight mass...

Bioremediation is a low-cost approach for crude oil spill remediation, but it often limited by electron acceptor availability. In addition, the biodegradation products of contaminants are complex, and transformation pathways difficult to decipher. This study demonstrates that bioelectrochemical systems (BESs) can be effective in degradation integrating biological electrochemical pathways, more importantly, provides first understanding on daughter hydrocarbon degradation. Using electrospray...

Low-carbohydrate (e.g., Atkins) dietary pattern is one of the most effective diets for weight loss, but little known about characteristics gut microbiota accompanying low-carbohydrate diets-induced loss. This study aims to profile dynamics bacteria and fungi modified Atkins loss among overweight obese adults. Overweight adults were screened follow a diet plan (30% energy from protein, 40% carbohydrate 30% fat). We longitudinally profiled based on 16S rRNA ITS gene sequencing data,...

Abstract O-linked β-N-acetylglucosamine (O-GlcNAc) modification exists widely in cells, playing a crucial role the regulation of important biological processes such as transcription, translation, metabolism, and cell cycle. O-GlcNAc is an inducible reversible dynamic protein post-translational modification, which regulates complex cellular activities through transient glycosylation deglycosylation. specifically regulated by glycosyltransferase (O-GlcNAc transferase, OGT) glycoside hydrolase...

Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic steatohepatitis (MASH) are characterized by excessive triglyceride accumulation in the liver. However, due to an incomplete understanding of its pathogenesis, more efforts needed identify specific effective treatments. N4-acetylcytidine (ac4C) is a newly discovered RNA modification regulate mRNA. N-acetyltransferase 10 (NAT10) has not been fully explored MASLD MASH.

Neural-like P systems are membrane computing models inspired by natural and viewed as third-generation neural network models. Although real neurons have complex structures, classical neural-like simplify the structures corresponding mechanisms to two-dimensional graphs or tree-based firing forgetting communications, which limit applications of these In this paper, we propose a hypergraph-based numerical (HNN) system containing five types describe high-order correlations among neuron...

Hydrocarbon-rich pyrolysis oils produced from landfill waste and recycled plastics are potential sources for fuels chemicals. It is well established that feedstock composition significantly affects oil and, hence, its uses. For example, contain a high concentration of hydrocarbons, whereas biomass have oxygen content. Previous studies shown the addition to increases hydrocarbon content; however, detailed analysis hydrocarbons polar species "real world" mixed municipal materials has not yet...

Oxidative stress has been proven to be essential in the pathogenesis of ulcerative colitis (UC). Therefore, this study was designed investigate effect Gegen Qinlian decoction (GQ) on Nrf2 pathway treatment UC and explore potential mechanism.

The immunosuppressive effects of dexmedetomidine, a highly selective and widely used a2-adrenoceptor agonist for sedation, analgesia, stress management, are investigated in vitro. In the present study, respiratory burst human neutrophils separated from venous blood was evaluated with dexmedetomidine treatment after Escherichia coli stimulation. five concentrations (1, 5, 10, 50, 100 μg/mL) were by rhodamine flow cytometer. nitric oxide (NO) production synthase (iNOS) activity also determined...

Efforts to enhance the transformative potential of biofuels is an important step achieving environment-friendly and sustainable energy source. Fremyella diplosiphon ideal third-generation biofuel agent due its ability produce lipids desirable essential fatty acids. In this study, impact Nanofer 25s nanoscale zero-valent iron nanoparticles (nZVIs) on total lipid content acid composition F. strains SF33 B481 was investigated. We observed significant increases (P < 0.05) in growth treated with...

Abstract Evidence for the natural microbial remediation of subsurface fuel contamination situations should include identification and analysis transformation or degradation products. In this way. u mass balance between constituents end products may be approached to monitor cleanup progress. Application advanced organic acid metabolite derivatization techniques several known sites compounds mixture provide valuable information on pathways progress transformation. Good correlation observed...

Thermogravimetric analysis experiments were carried out to investigate the pyrolysis properties of neutral sulfite semi-chemical pulp (NSSC) black liquor ranging from room temperature 800°C with heating rates 20°, 30°, 50°C/min. Experimental results show that quickly loses weight in range 170°–370°C, 370°–570°C, and 570°–800°C. The organic volatiles are mostly released former two ranges, while alkali metal salts decompose, volatilize, react third range. mechanism function NSSC is determined...

Plasminogen activator inhibitor 1 (PAI‐1), a member of the serpins, has unique conformational flexibility. A typical characteristic is its intrinsic lability resulting in conversion active conformation to latent conformation. In present study, we have evaluated effect substitution positively charged residues located at turn connecting strand s4C with s3C, either negatively or neutral residues, on functional stability PAI‐1. The following mutants were constructed, purified and characterized...

Experiments were carried out to investigate the agglomeration mechanism of neutral sulfite semi-chemical (NSSC) black liquor combusted in a bench-scale fluidized bed. The combustion experiments focused on influence different operating conditions at temperatures ranging from 600 800 °C and additive dosages 0 30% with additives (kaolin, calcium carbonate, alumina). Defluidization resulting occurred frequently experiments. Samples bed material collected after characterized by scanning electron...