A5017220676- Glioma Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Mitochondrial Function and Pathology
- Protein Hydrolysis and Bioactive Peptides
- Neurogenesis and neuroplasticity mechanisms
- Brain Metastases and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Gut microbiota and health
- Tryptophan and brain disorders
- Diet and metabolism studies
- Biochemical and Molecular Research
- Alcohol Consumption and Health Effects
- Glycosylation and Glycoproteins Research
- Nutritional Studies and Diet
- Sugarcane Cultivation and Processing
- Microbial Natural Products and Biosynthesis
- Lung Cancer Research Studies
- Immune cells in cancer
- Autophagy in Disease and Therapy
- Genetics, Aging, and Longevity in Model Organisms
- Melanoma and MAPK Pathways
- Cell Image Analysis Techniques
- Wnt/β-catenin signaling in development and cancer
First Affiliated Hospital of Guangzhou Medical University
2020-2025
State Key Laboratory of Respiratory Disease
2020-2025
Guangzhou Medical University
2020-2025
In-Q-Tel
2023
Sichuan University
2021
West China Hospital of Sichuan University
2021
University of Virginia
2013-2020
Sun Yat-sen University
2018-2019
University of Exeter
2019
Universität Hamburg
2019
Decreasing β-amyloid (Aβ) accumulation is of significance in finding therapeutic candidates for cognitive impairments Alzheimer's disease (AD). The aim this study to investigate the potency active components walnut protein decreasing Aβ aggregation and ameliorating impairments.Cell model intracellular Aβ42 used explore ingredients hydrolysate (WPH). A bioactive peptide (Pro-Pro-Lys-Asn-Trp, PW5) with great anti-Aβ42 activity identified from WPH synthesized vitro vivo experiments. Using...
The balance between self-renewal and differentiation of adult neural stem cells (aNSCs) is essential for the maintenance aNSC reservoir continuous supply new neurons, but how this fine-tuned in brain not fully understood. Here, we investigate role SIRT1, an important metabolic sensor epigenetic repressor, regulating hippocampal neurogenesis mice. We found that there was increase SIRT1 expression during differentiation. In Sirt1 knockout (KO) mice, as well brain-specific inducible...
Young neurons in the developing brain establish a polarized morphology for proper migration. The PIWI family of piRNA processing proteins are considered to be restrictively expressed germline tissues and several types cancer cells. They play important roles spermatogenesis, stem cell maintenance, biogenesis, transposon silencing. Interestingly recent study showed that de novo mutations members strongly associated with autism.Here, we report PIWI-like 1 (PIWIL1), member known essential...
Brain metastasis is thought to be related the high mortality and poor prognosis of lung cancer. Despite significant advances in treatment primary cancer, unique microenvironment brain renders current therapeutic strategies largely ineffective against metastasis. The lack effective drugs for primarily due incomplete understanding mechanisms underlying its initiation progression. Currently, our remains limited, absence appropriate models that can realistically simulate entire process tumor...
Abstract Background The morphogenesis of the cerebral cortex depends on precise control gene expression during development. Small non-coding RNAs, including microRNAs and other groups small play profound roles in various physiological pathological processes via their regulation expression. A systematic analysis profile RNAs developing cortical tissues is important for clarifying networks mediating key developmental events morphogenesis. Results Global profiling RNA transcriptome was carried...
Abstract The majority of the immune cell population in tumor microenvironment (TME) consists tumor-associated macrophages (TAM), which are main players coordinating inflammation. TAM has a high plasticity and is divided into two phenotypes, pro-inflammatory M1 type anti-inflammatory M2 type, with tumor-suppressive tumor-promoting functions, respectively. Considering beneficial effects for anti-tumor macrophages, conversion to feasible positive treatment. This study sought evaluate whether...
Abstract We aimed to identify skipjack elastin hydrolysate‐derived peptides, and explore its mechanism of photoprotection against ultraviolet A (UVA) induced skin damage. Two TGVLTVM (peptide A) NHIINGW B), were successfully identified using Sephadex G‐15, analyzed detected LC‐MS/MS fitted with electrospray ionization (ESI‐MS/MS), further synthesized the Fmoc strategy. UVA radiation‐induced damage cell model Human keratinocytes line (HaCaT) was established applied. found that both peptides...
In spite of recent advances in the field undernutrition, current dietary therapy relying on supply high protein calorie formulas is still plagued with transient recovery impaired organs resulting significant relapse cases. This partly attributed to inadequacy research models recapitulating clinical undernutrition for mechanistic exploration. Using 1636 Macaca fascicularis monkeys, a human-relevant criterion determining weight-for-age z-score (WAZ), cutoff point ≤ -1.83 established as...
Grifola frondosa has been shown to induce immune modulatory, modulate autophagy, and apoptosis in cancer cells. However, little is known about its potential for managing tumor progression as an adjunct nutrient restriction.
Abstract Background Lung cancer brain metastases (LC-BrMs) are frequently associated with dismal mortality rates in patients lung cancer; however, standard of care therapies for LC-BrMs still limited their efficacy. A deep understanding molecular mechanisms and tumor microenvironment will provide us new insights into developing novel therapeutics treating LC-BrMs. Methods Here, we performed integrated analyses genomic, transcriptomic, proteomic, metabolomic, single-cell RNA sequencing data...
Prodrug, in which the inactive parent drug with good bioavailability is metabolized into an active body, one of main strategies to target disease site improve efficiency and reduce adverse effects chemotherapy. Because capability chemical modification, zein, a plant derived protein, drugs can be conjugated through environmentally sensitive links form prodrugs capable triggered release. In this study, novel prodrug was synthesized using paclitaxel (PTX), disulfide linker, nanoparticles were...
Gastric cancer (GC) has high morbidity and mortality rates worldwide. Abundant literature reported several individual genes their related pathways intimately involved in tumor progression. However, little is known about GC progression at the gene network level. Therefore, understanding underlying mechanisms of pathological transition from early stage to late urgently needed. This study aims identify potential vital modules GC. To understand regulatory progression, we analyzed micro RNAs...
Hyperuricemia is a purine metabolism disorder, with increasing prevalence worldwide. Here, high throughput cell model for screening of antihyperuricemic compounds was set up. Human kidney cells (HK2 cells) were stimulated adenosine and the resulting supernatant lysate then analyzed using performance liquid chromatography (HPLC). The results showed that hypoxanthine content increased in both HK2 xanthine oxidase (XO)-overexpressing lysate, but no uric acid detected due to lower endogenous XO...
Mitochondrial dysfunction is proposed to be substantially associated with ageing and ageing-related diseases like Alzheimer's disease (AD). However, it unclear whether different mouse models mitochondrial-related have similar changes in mitochondrial morphology of the same tissues. Moreover, similarities can a suitable marker for screening and/or discovering mitochondrial-protective substances remains unknown. Mitochondria tissues novel outer membrane protein Slc25a46 knockout traditional...