A5103194621- Immune Response and Inflammation
- Cell death mechanisms and regulation
- Cancer, Stress, Anesthesia, and Immune Response
- Neuropeptides and Animal Physiology
- Chemokine receptors and signaling
- Sleep and Wakefulness Research
- Immunotherapy and Immune Responses
- Muscle metabolism and nutrition
- Gout, Hyperuricemia, Uric Acid
- Lipid metabolism and disorders
- Hematological disorders and diagnostics
- Restless Legs Syndrome Research
- Systemic Lupus Erythematosus Research
- Parkinson's Disease Mechanisms and Treatments
- Inflammasome and immune disorders
- Adipose Tissue and Metabolism
- Bacterial Infections and Vaccines
- ATP Synthase and ATPases Research
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Cytokine Signaling Pathways and Interactions
- Receptor Mechanisms and Signaling
- NF-κB Signaling Pathways
- Infectious Diseases and Tuberculosis
- Osteoarthritis Treatment and Mechanisms
Duke University
2021
Tri-Service General Hospital
2010-2017
National Defense Medical Center
2006-2017
Kaohsiung Medical University
2014
Institute of Molecular Biology, Academia Sinica
2009
Institute of Molecular Biology
2007
National Chi Nan University
2005
mcl-1, a bcl-2 family member, was originally identified as an early gene induced during differentiation of ML-1 myeloid leukemia cells. In the present study, we demonstrate that Mcl-1 is tightly regulated by granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway. Upon deprivation survival from TF-1 progenitor cells, levels quickly dropped prior to visible detection apoptosis these restimulation deprived cells with GM-CSF, mcl-1 mRNA immediately and its protein product...
Translationally controlled Tumor Protein (TCTP) is an evolutionally highly conserved protein which has been implicated in many cellular functions that are related to cell growth, death, and even the allergic response of host. To address physiological roles TCTP, we generated TCTP knockout mice by targeted gene disruption. Heterozygous mutants appeared be developmentally normal. However, homozygous (TCTP(-/-)) were embryonic lethal. TCTP(-/-) embryos smaller size than control littermates at...
Mcl-1 functions at an apical step in many regulatory programs that control cell death. Although the mitochondrion is one major subcellular organelle where functions, molecular mechanism by which targeted to mitochondria remains unclear. Here, we demonstrate loosely associated with outer membrane of mitochondria. Furthermore, interacts mitochondrial import receptor Tom70, and such interaction requires internal domain contains EELD motif. A Tom70 antibody blocks Mcl-1-Tom70 vitro....
Background: Gout is a common form of inflammatory arthritis that triggered by the crystallization monosodium urate (MSU). We investigated potential proteins relate to pathogenesis or spontaneous resolution acute gouty arthritis.
Sleep-related movement disorders (SRMD) have been shown to increase the risk of cardiovascular diseases. However, relationship between SRMD and stroke remains unclear. To explore in general population. Two cohorts patients with without were followed up for occurrence hemorrhagic ischemic stroke. The study cohort enrolled 604 who initially diagnosed as 2000 2005. 2,416 age- sex-matched prior selected comparison cohort. A Cox-proportional hazard regression analysis was performed multivariate...
Tumour necrosis factor (TNF) is capable of activating the cell death pathway, and has been implicated in killing transformed cells. However, TNF also activates survival signals, including NF-kappaB activation subsequent expression anti-apoptotic genes, leading to protection against toxicity.In this study, we show that, although untransformed mouse embryonic fibroblasts (MEFs) were resistant killing, E1A/Ras-transformed MEFs susceptible extensive apoptosis induced by TNF. The key factors for...
Translationally controlled tumor protein (TCTP) is expressed throughout T cell development and prominently induced following activation. However, its function(s) during these processes unclear. Here, we demonstrated that conditional deletion of TCTP before the beta selection checkpoint resulted into a partial block thymocyte at double-negative (DN) 3 stage. Deletion in double-positive (DP) stage did not cause any significant phenotype thymus except slight increase mature CD8 single-positive...