Hepatocytes are the primary functional cells of liver, performing its metabolic, detoxification, and endocrine functions. Functional hepatocytes extremely valuable in drug discovery evaluation, as well cell therapy for liver diseases. However, it has been a long-standing challenge to maintain functions vitro. Even freshly isolated lose essential after short-term culture reasons that still not understood. In present study, we find mechanical tension-induced yes-associated protein activation...

Introduction Visceral adipose tissue (VAT) plays a crucial role in regulating systemic metabolic balance. Excess accumulation of VAT is closely associated with various disorders, process that involves the coordinated actions multiple cell types within tissue. Cold exposure, as potential intervention, has been proposed to improve dysfunction. However, heterogeneity and its comprehensive characteristics under cold exposure remain unclear. Methods We collected epididymal white (eWAT) C57BL/6J...

In recent years, immune checkpoint inhibitors (ICIs) have emerged as a novel immunotherapeutic approach, offering renewed hope for enhancing cervical cancer patient prognosis. This study represents the inaugural bibliometric analysis of ICIs in context cancer, covering period from 2014 to 2024. A total 422 articles were identified through Web Science Core Collection database, amassing 10,977 citations, with consistent annual increase number publications. The leading contributors terms...

Abstract Background CAR-T cell therapy faces challenges in solid tumor treatment and hematologic malignancy relapse, among which the limited persistence of cells target antigen downregulation are prominent factors. Therefore, we engineered an NKG2D/CD28 chimeric co-stimulatory receptor (CCR), leveraging its broad ligand expression on tumors to enhance antitumor activity MSLN CAR CD19 cells. Methods We generated co-expressing CCR assessed their efficacy vitro vivo. activation,...

Maintaining and manipulating sequences online is essential for daily activities such as scheduling a day. In Parkinson9s disease (PD), sequential working memory deficits have been associated with altered regional activation functional connectivity in the basal ganglia. This study demonstrates that substantia nigra (SN) integrity correlated ganglia function sequencing performance 29 patients PD (17 women) healthy controls (HCs; 18 women). neuromelanin-sensitive structural magnetic resonance...

Abstract Purpose Sequential working memory is the ability to maintain and manipulate sequential information at a second time scale. Patients with progressive supranuclear palsy (PSP) or Parkinson's disease (PD) perform poorly in tests that require flexible arrangement of thoughts actions. This study investigated whether differently impaired patients PSP versus PD. Method Twenty‐nine Richardson's syndrome (PSP‐RS), 36 PD, healthy controls (HC) completed 3 well‐established neuropsychological...

The efficient synthesis of porphyrin– and chlorin–NSAID conjugates, their singlet oxygen generation capacity HEp2 cell toxicity are reported.

Maintaining the ability to arrange thoughts and actions in an appropriate serial order is crucial for complex behavior. We aimed investigate age differences fronto-striato-parietal network underlying ordering using functional magnetic resonance imaging. exposed 25 young 27 older healthy adults a digit task, where they had reorder recall sequential digits or simply them. detected comprising of lateral medial prefrontal, posterior parietal, striatal regions. In adults, prefrontal parietal...

Abstract Purpose: The indispensable role of long non-coding RNAs (lncRNAs) in tumorigenesis has been increasingly reported. In the present study, LINC01694 was found to regulate proliferation, invasion, as well apoptosis gallbladder cancer (GBC) cells through sponging miR-340-5p. Methods: level GBC quantified by quantitative real-time polymerase chain reaction (qRT-PCR). and were determined Cell Counting Kit-8 (CCK-8), Transwell, flow cytometry, respectively. expression Sry-related...

Deficits in maintaining and manipulating sequential information online can occur even patients with mild Parkinson's disease. The subthalamic nucleus may play a modulatory role the neural system for working memory, which also includes lateral prefrontal cortex.The objective of this study was to investigate markers memory deficits de novo disease.A total 50 disease healthy controls completed digit ordering task during functional magnetic resonance imaging scanning. separated maintenance...

Abstract BackgroundBreast reconstruction is widely used for women undergoing mastectomy. Prosthetic implants have become a common technique performed these because of their safety, flexibility and adjustable size. There are few reports implant-associated squamous cell carcinoma. In addition to this report, only 8 including 11 cases been reported in the English literature.Case presentationWe report case patient with breast prosthetic carcinoma who received mastectomy 10 years ago. She was...

Semantic fluency is the ability to name items from a given category within limited time, which relies on semantic knowledge, working memory, and executive function. Similar patients with Parkinson's disease (PD), progressive supranuclear palsy (PSP) scored lower than healthy adults in well-established test. However, it unclear how unique are produced words. This study examined relationship between words' uniqueness PSP.

Semantic fluency is the ability to name items from a given category within limited time, which relies on semantic memory, working and executive function. disfluency common problem in Parkinson’s disease (PD) Alzheimer’s (AD). We demonstrated graph theoretical analysis of patients with PD ( <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mi>N</a:mi> <a:mo>=</a:mo> <a:mn>86</a:mn> </a:math> ), AD <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" id="M2"> <c:mi>N</c:mi>...

The ability to arrange thoughts and actions in an appropriate serial order is impaired Parkinson's disease (PD). However, it unclear how represented manipulated the representation or manipulation altered early stages of PD. We aimed analyze pattern performance errors ordering versus recall nondemented PD patients with mild clinical symptoms healthy adults identify underlying principles ordering.PD (N = 57) controls 40) completed adaptive digit span forward tests. focused on items recalled...

The well-established semantic fluency test measures the ability to produce a sequence of spoken words from particular category within limited period time. Like patients with Parkinson’s disease (PD), progressive supranuclear palsy (PSP) tend fewer correct than age-matched healthy adults. This study further examined difference between PSP and PD in their performance using graph theory-based approach. Twenty-nine Richardson’s syndrome (PSP-RS), thirty-eight PD, fifty-one controls (HC) were...

Mitochondrial chronic progressive external ophthalmoplegia (CPEO) is a major manifestation of human mitochondrial encephalomyopathies. Previous studies have shown cognitive deficits in patients with diseases. However, these often included heterogeneous subtypes Here, we aimed to provide better profile CPEO by applying comprehensive battery neuropsychological assessments pure sample CPEO. We recruited 28 (19 women, age 16-62 years) and 38 age- education-matched healthy control subjects (25...

Abstract Osteosarcoma (OS) is the most common primary malignant tumor of skeletal system in clinic. It mainly occurs adolescent patients and pathogenesis disease very complicated. The distant metastasis may occur early stage, prognosis poor. MicroRNAs (miRNAs) are non-coding RNAs about 18–25 nt length that involved post-transcriptional regulation genes. miRNAs can regulate target gene expression by promoting degradation mRNAs or inhibiting translation process, thereby proliferation OS cells...

SY-007 is an interfering peptide designed to disrupt the cell death signaling of phosphatase and tensin homolog deleted on chromosome ten (PTEN) nuclear translocation during ischemic stroke. Preclinical studies indicated that rats treated with 1.5 mg/kg in middle cerebral artery occlusion (MACO) model had significantly reduced stroke lesion size even when administered 6 h after onset. The aim this study was evaluate safety, tolerability, pharmacokinetics ascending doses intravenously healthy...

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