A5079376838- Virology and Viral Diseases
- Animal Virus Infections Studies
- IL-33, ST2, and ILC Pathways
- Virus-based gene therapy research
- MicroRNA in disease regulation
- Influenza Virus Research Studies
- Eosinophilic Esophagitis
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Cancer-related molecular mechanisms research
- Infant Nutrition and Health
- Autophagy in Disease and Therapy
- Asthma and respiratory diseases
- Biofuel production and bioconversion
- Cancer, Hypoxia, and Metabolism
- Catalysis for Biomass Conversion
- Cancer Cells and Metastasis
- Gut microbiota and health
- HIV Research and Treatment
- Immune Response and Inflammation
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Nuclear Structure and Function
- Milk Quality and Mastitis in Dairy Cows
Yangzhou University
2014-2024
Tianjin Medical University
2014-2024
Xuzhou University of Technology
2022-2024
Weatherford College
2023
Creative Commons
2023
Second People’s Hospital of Huai’an
2021
Xuzhou Medical College
2021
// Shi-Peng Li 1, * , Hai-Xu Xu 3, Yao Yu Jin-Dan He Zhen Wang 1 Yan-Jie Chang-Ying 3 Hai-Ming Zhang 2 Rong-Xin 4 Jian-Jun Zhi Zhong-Yang Shen First Central Clinical College, Tianjin Medical University, Tianjin, P.R. China Oriental Organ Transplant Center of Hospital, Key Laboratory Transplantation P.R.China Department Immunology, Cellular and Molecular Immuno Microenvironment Disease the Educational Ministry, Immunology Inflammation, Immune Diseases Ministry China, Basic These authors have...
Cancer-associated fibroblasts (CAFs) are one of the most enriched components Hepatocellular carcinoma (HCC) microenvironment, which tightly related to metastasis and invasion HCC. We identified a mechanism by CAF-derived chemokine CCL5 enhanced HCC triggering HIF1α/ZEB1 axis. demonstrated that CAFs derived from tissues promoted migration cells facilitated lung NOD/SCID mice. Then antibody array elucidated higher level secreted than paracancerous tissue (PTFs). Mechanistically, we found...
Hepatocellular carcinoma is a malignant tumor that poses serious threat to human health. Ferroptosis, which represents an identified type of regulated iron-dependent cell death, may play important role in hepatocellular carcinoma. However, it unclear as whether ferroptosis involved with the mechanisms lncRNA HULC liver cancer cells. Here, we show knockdown increases and oxidative stress We also found changes some related miRNAs cells treated siRNA. Differential miRNA expression levels were...
Cancer stem cells in liver cancer are thought to be responsible for tumor recurrence and metastasis. However, the factors that mediate this mechanism have yet completely elucidated. In study, we isolated CD13+CD44+ sphere (SCs) derived from tissues SK-Hep-1 cells, which possessed cell-like properties. Through cytokine array analysis, growth differentiation factor 15 (GDF15) was significantly increased SCs. Clinical data showed GDF15 overexpressed positively related pathological grading....
// Yuting Huang 1,2,* , Meng Zhao 2,* Haixu Xu 2 Ke Wang 1 Zheng Fu Yuan Jiang and Zhi Yao Tianjin Medical University Cancer Institute Hospital, National Clinical Research Center of Cancer, Key Laboratory Prevention Therapy, Tianjin, P.R. China Department Immunology, Cellular Molecular Educational Ministry China, School Basic Sciences, University, * These authors contributed equally to this work Correspondence: Yao, email: Keywords : ovarian cancer, RASAL2, EMT, MAPK, metastasis Received May...
Inflammatory bowel disease (IBD) is a multifaceted and recurrent immune disorder that occurs in the gastrointestinal tract. Betaine natural compound exerts beneficial anti-inflammatory effects. However, role of betaine protecting IBD still unclear. Therefore, aim our study was to investigate effect dextran sulfate sodium (DSS)-induced colitis. The results showed greatly increased body weight decreased activity index score DSS-treated mice. Furthermore, effectively downregulated protein...
Newcastle disease (ND) is one of the most contagious and devastating diseases to poultry in world. The causative agents are virulent strains virus (NDV), which belong genus Avulavirus, sub-family Paramyxoviridae, family Paramyxovirinae. Knowing genomic antigenic characteristics NDVs might contribute ND control China.The results showed that all belonged sub-genotype VIId shared same cleavage site (112)RRQKR/F(117) fusion protein. At least 69 % (38 55) NDV possessed E347K variation...
Newcastle disease (ND) leading to heavy economic losses the poultry industry worldwide is caused by virus (NDV). Even though intensive vaccination programs have been implemented in many countries, virulent NDV can still be frequently isolated well-vaccinated flocks. We compared protection efficiency of LaSota and two sub-genotype VIId vaccines, NDV/AI4 O/AI4, which O/AI4 was constructed replacing hemagglutinin–neuraminidase (HN) gene vaccine strain with that from variant JS-14-12-Ch cross...
This work aimed to determine the effect of freeze drying (FD), hot air (HD), vacuum (VD), and infrared (IRD) on quality two key kinds garlic varieties (white purple garlic). The including colors, bioactive compounds, antioxidant capacities dried slices were investigated. highest whiteness white was found in FD treatments with its values at 87.04 81.89, respectively. higher active substances contents compared ones under same methods. allicin IRD treated 2.60 2.67 mg/g total phenolic these...
Abstract Microbiota have an important function in shaping and priming neonatal immunity, although the cellular molecular mechanisms underlying these effects remain obscure. Here we report that prenatal antibiotic exposure causes significant elevation of group 2 innate lymphoid cells (ILC2s) lungs, both cell numbers functionality. Downregulation type 1 interferon signaling ILC2s due to diminished production microbiota-derived butyrate represents mechanism. Mice lacking receptor GPR41 ( Gpr41...
The strains of Newcastle disease virus (NDV) can be divided into two distinct clades: class I and II. At present, limited molecular epidemiological data are available for the at live bird markets (LBMs). Knowing genomic antigenic characteristics NDVs might provide important insights evolution dynamics these viruses. In this study isolated from LBMs in Eastern China between 2008 2012 were characterized. We characterized 34 genetically 15 pathologically which originated geese, chickens ducks...
The matrix (M) protein of Newcastle disease virus (NDV) is demonstrated to localize in the nucleus via intrinsic nuclear localization signal (NLS), but cellular proteins involved import NDV M and role M's replication pathogenicity remain unclear. In this study, importin β1 was screened interact with by yeast two-hybrid screening. This interaction subsequently confirmed co-immunoprecipitation pull-down assays. vitro binding studies indicated that NLS region amino acids 336-433 belonged RanGTP...
Newcastle disease virus (NDV) has been extensively studied as a promising oncolytic for killing tumor cells in vitro and vivo clinical trials. However, the viral components that regulate activity of NDV remain incompletely understood. In this study, we systematically compared replication ability different genotypes various identified NP protein determines NDV. On one hand, strains with phenylalanine (F) at 450th amino acid position (450th-F-NP) exhibit loss activity. This phenotype is...
The strains of the genotype VIId Newcastle disease virus (NDV) induce more severe tissue damage in lymphoid organs than other virulent strains. underlying molecular mechanisms are poorly understood.Genotype IV NDV Herts/33 and JS5/05 have a distinctive pathological profile spleen. These two viruses were selected as parental to generate panel chimeric by replacing M, F HN genes individually or combination with corresponding using reverse genetic. Virulence vitro characteristics recombinant...
Group 2 innate lymphoid cells (ILC2s) have emerged as critical mediators in driving allergic airway inflammation. Here, we identified angiotensin (Ang) II a positive regulator of ILC2s. ILC2s expressed higher levels the Ang receptor AT1a, and colocalized with lung epithelial expressing angiotensinogen. Administration significantly enhanced ILC2 responses both vivo vitro, which were almost completely abrogated AT1a-deficient mice. Deletion AT1a or pharmacological inhibition II–AT1 axis...
Necrotizing enterocolitis (NEC) is a common disorder in premature infants that characterized by hyperinflammation and severe necrosis the intestine. The pathogenesis of NEC remains to be elucidated. In this study, we demonstrate adenosine, metabolite more abundant than adults, plays an important role prevention NEC. Administration adenosine or its analog, adenosine-5'-N-ethyluronamide (NECA), dramatically relieved severity neonatal mice. Meanwhile, treatment significantly enhanced...
Escherichia coli (E. coli) is one of the best-known zoonotic bacterial species, which pathogenic strain can cause infections in humans and animals. However, existing technologies or methods are deficient for quickly on-site identifying infection E. before they breakout. Herein, we present an ultrasensitive method counting using magnetic nanoparticle (MNP) probe under a dark-field 30 min.The antibodies functionalized MNP, binding to form golden ring-like structure microscope, allowing coli....
Newcastle disease (ND), an acute and highly contagious avian caused by virulent virus (NDV), often results in severe economic losses worldwide every year. Although it is clear that microRNAs (miRNAs) are implicated modulating innate immune response to invading microbial pathogens, their role host defense against NDV infection remains largely unknown. Our prior study indicates gga-miR-19b-3p up-regulated NDV-infected DF-1 cells (a chicken embryo fibroblast cell line) functions suppress...