A5083680984- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Allergic Rhinitis and Sensitization
- Pneumonia and Respiratory Infections
- RNA and protein synthesis mechanisms
- Eosinophilic Esophagitis
- Respiratory Support and Mechanisms
- Circular RNAs in diseases
- Neonatal Respiratory Health Research
- Genetic Associations and Epidemiology
- Antibiotic Resistance in Bacteria
- Dermatology and Skin Diseases
- Inhalation and Respiratory Drug Delivery
- IL-33, ST2, and ILC Pathways
- Respiratory viral infections research
- Nosocomial Infections in ICU
- Pediatric health and respiratory diseases
- Influenza Virus Research Studies
- Tuberculosis Research and Epidemiology
- Functional Brain Connectivity Studies
- Extracellular vesicles in disease
- Bioinformatics and Genomic Networks
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Guangzhou Medical University
2012-2022
Guangzhou Women and Children Medical Center
2012-2022
Boston Children's Hospital
2014
Abstract Background Although previous studies had confirmed the effectiveness and safety of subcutaneous immunotherapy (SCIT) sublingual (SLIT), respectively, direct head‐to‐head comparison SCIT vs SLIT is sparse. We aimed to compare efficacy, safety, compliance in allergic rhinitis (AR) children. Methods This study a prospective, open‐label, single‐center performed between June 2017 2018. A total 325 children were grouped into SLIT, Alutard (SCIT1), NovoHelisen Depot (NHD) (SCIT2) according...
Changes of miRNAs in exosome have been reported different disease diagnosis and provided as potential biomarkers. In this study, we compared microRNA profile exosomes 5 MHFMD ESHFMD well healthy children. Different expression across all the three groups were screened using miRNA microarray method. Further validated test was conducted through quantitative real-time PCR assays with 54 samples (18 ESHFMD, 18 MHFMD, control). The judgment accuracy then estimated by receiver operating...
Group 2 innate lymphoid cells (ILC2s) have emerged as critical mediators in driving allergic airway inflammation. Here, we identified angiotensin (Ang) II a positive regulator of ILC2s. ILC2s expressed higher levels the Ang receptor AT1a, and colocalized with lung epithelial expressing angiotensinogen. Administration significantly enhanced ILC2 responses both vivo vitro, which were almost completely abrogated AT1a-deficient mice. Deletion AT1a or pharmacological inhibition II–AT1 axis...
Community-acquired pneumonia in children is common China. To understand current clinical characteristics and practice, we conducted a cross-sectional study to analyze quality of care on childhood eight eastern cities
The bidirectional relationship between the brain cortex and cardiovascular diseases (CVDs) remains inadequately explored.
Abstract To observe a therapeutic effect of macrolide antibiotics in children with Pseudomonas aeruginosa pneumonia. Fifty-four cases pneumonia were randomly divided into an observation group (n=30) and control (n=24). The was treated cefoperazone/sulbactam. cefoperazone/ sulbactam during course 10-14 days. total effective rate 93.3% the group, 58.3% results superior to notably (P>0.05). There no significant differences bacterial clearance rate, adverse reaction between two groups...
Abstract Background To clarify the molecular mechanisms that participate in severe hand, foot and mouth disease (HFMD) infected by Enterovirus 71 to detect any related protein biomarkers, we performed proteomic analysis of extracts from 5 extremely HFMD children healthy children. Methods The profiles them were compared using two-dimensional electrophoresis. Differentially expressed proteins identified mass spectrometry. Functional classifications these based on PANTHER. interaction network...
Objective: To evaluate the efficacy and safety of oseltamivir in treatment suspected influenza children. Method: A multicenter, randomized open-label trial was conducted among 229 individuals with which were collected from clinic 5 hospitals Guangdong province (Guangzhou Women Children's Medical Center, Shenzhen Baoan District Maternity Child Care Service Second Affiliated Hospital Shantou University College, Dongguan Centre, Yuexiu Guangzhou) April to July 2015. They either group...
Objective To explore the development of pulmonary function normal toddlers between 1 and 3 years old.Methods Totally 115 were divided into 2 groups according to their age,i.e,1 ～ old,2～3 old.The indicator small big airway examine respiratory system static compliance,total resistance functional residual volume observed.Results No significant difference was found male female toddler( P ＞0.05 ).Between two groups,the rate not significant( 27 vs 26,t =1.512,P ).The values tidal volumes in group...
Objective To observe the clinical effects and safety degree of treating children's cough variant asthma for mite allergy with Montelukast sodium combined Flixotide. Methods Forty cases infant patients in Guangzhou Women Children's Medical Center from February 2012 to October 2013 were taken as research subjects randomly divided into treatment group control group, each 20 cases.The was treated Flixotide aerosol; took extra medicine chewable tablets.The period covered half a year.After...