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Contact & Profiles
A5027940641
Research Areas
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
Tianjin Medical University
2022
Group 2 innate lymphoid cells (ILC2s) have emerged as critical mediators in driving allergic airway inflammation. Here, we identified angiotensin (Ang) II a positive regulator of ILC2s. ILC2s expressed higher levels the Ang receptor AT1a, and colocalized with lung epithelial expressing angiotensinogen. Administration significantly enhanced ILC2 responses both vivo vitro, which were almost completely abrogated AT1a-deficient mice. Deletion AT1a or pharmacological inhibition II–AT1 axis...
10.1084/jem.20211001
article
EN
cc-by-nc-sa
The Journal of Experimental Medicine
2022-01-19
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