A5058551375- Virology and Viral Diseases
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Influenza Virus Research Studies
- Virus-based gene therapy research
- Vector-Borne Animal Diseases
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches
- RNA Interference and Gene Delivery
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- HIV Research and Treatment
- MicroRNA in disease regulation
- interferon and immune responses
Yangzhou University
2018-2024
Newcastle disease virus (NDV) has been extensively studied as a promising oncolytic for killing tumor cells in vitro and vivo clinical trials. However, the viral components that regulate activity of NDV remain incompletely understood. In this study, we systematically compared replication ability different genotypes various identified NP protein determines NDV. On one hand, strains with phenylalanine (F) at 450th amino acid position (450th-F-NP) exhibit loss activity. This phenotype is...
Abstract The haemagglutinin–neuraminidase (HN) protein, a vital membrane glycoprotein, plays pivotal role in the pathogenesis of Newcastle disease virus (NDV). Previously, we demonstrated that mutation HN protein is essential for enhanced virulence JS/7/05/Ch, velogenic variant NDV strain originating from mesogenic vaccine Mukteswar. Here, explored effects during viral infection vitro using three viruses: Mukteswar, and an HN-replacement chimeric NDV, JS/MukHN. Through microscopic...
Newcastle disease (ND), an acute and highly contagious avian caused by virulent virus (NDV), often results in severe economic losses worldwide every year. Although it is clear that microRNAs (miRNAs) are implicated modulating innate immune response to invading microbial pathogens, their role host defense against NDV infection remains largely unknown. Our prior study indicates gga-miR-19b-3p up-regulated NDV-infected DF-1 cells (a chicken embryo fibroblast cell line) functions suppress...
Pigeon paramyxovirus type 1 (PPMV-1) is an antigenic variant of Newcastle disease virus (NDV) which mainly associated with infections pigeons and has the potential to result in chickens. In this study, we characterised 21 PPMV-1 isolates from diseased China during 2007-2019. Phylogenetic analysis revealed that all belonged genotype VI. Among them, most sub-genotype VI.2.1.1.2.2, suggesting VI.2.1.1.2.2 become a prevalent China. The results showed were mesogenic nature according mean death...
Pigeon paramyxovirus type 1 (PPMV-1) is considered as an antigenic variant of Newcastle disease virus (NDV) which has obvious host preference for pigeons and caused significant economic losses to the global poultry industry. The evolutionary dynamics PPMV-1 in China, however, are poorly understood. In this study, we characterized seven isolates from diseased collected Jiangsu, Anhui, Henan provinces during 2020. Phylogenetic analysis revealed that belonged sub-genotype VI.2.1.1.2.2....
Highly pathogenic (HP) H7N9 avian influenza virus (AIV) emerged in China 2016. HP AIV caused at least 33 human infections and has been circulating poultry farms continuously since wave 5. The genetic divergence, geographic patterns, hemagglutinin adaptive parallel molecular evolution of 2017 are still unclear. Here, 10 new strains AIVs from October 2019 to April 2021 were sequenced. We found that was primarily Northern China, particularly the provinces surrounding Bohai Sea (Liaoning, Hebei,...
As a multifunctional protein, the hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) is involved in various biological functions. A velogenic genotype III NDV JS/7/05/Ch evolving from mesogenic vaccine strain Mukteswar showed major amino acid (aa) mutations HN protein. However, precise significance mutant remains unclear. This study sought to investigate effects on activities vitro and vivo. The (JS/7/05/Ch-type HN) significantly enhanced hemadsorption (HAd) fusion...
Reassortment with the H9N2 virus gave rise to zoonotic H7N9 avian influenza (AIV), which caused more than five outbreak waves in humans, high mortality. The frequent exchange of genomic segments between and has been well-documented. However, reassortment patterns have not described are yet fully understood. Here, we used phylogenetic analyses investigate intersubtype intrasubtype/intralineage across eight viral segments. its progeny frequently exchanged internal genes but rarely other AIV...
Pigeon Newcastle disease (ND) is the most common viral infectious in pigeon industry, caused by paramyxovirus type 1 (PPMV-1), a variant of chicken-origin virus (NDV). Previous studies have identified significant amino acid differences between PPMV-1 and NDV at positions 347 349 hemagglutinin-neuraminidase (HN) protein, with predominantly exhibiting glycine (G) position glutamic (E) 349, while NDVs show E aspartic (D) 349. However, impact these substitutions remains unclear. In this study,...
Abstract Background: Live bird markets (LBMs) serve as a natural reservoir for class I Newcastle disease virus (NDV) and play an important role in viral evolution spread. LBMs commercial farms are the main sources of daily poultry products. However, limited studies available NDV circulating at farms. In this study, significant progress has been made sample detection genetic analysis Eastern China. Methods: A long-term epidemiological investigation China was conducted. We sequentially...