A5014942363- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Telomeres, Telomerase, and Senescence
- Birth, Development, and Health
- Retinal Diseases and Treatments
- RNA Research and Splicing
- Glaucoma and retinal disorders
- Genomics and Chromatin Dynamics
- Retinal Imaging and Analysis
- Genetic Mapping and Diversity in Plants and Animals
- ECG Monitoring and Analysis
- Central Venous Catheters and Hemodialysis
- Gastroesophageal reflux and treatments
- Phonocardiography and Auscultation Techniques
- RNA modifications and cancer
- Gene expression and cancer classification
- IL-33, ST2, and ILC Pathways
- Cardiac Arrhythmias and Treatments
- Cancer, Hypoxia, and Metabolism
- Child Nutrition and Feeding Issues
- Video Analysis and Summarization
- Internet Traffic Analysis and Secure E-voting
- Peer-to-Peer Network Technologies
- Cell Image Analysis Techniques
- Heart Rate Variability and Autonomic Control
Nanjing Medical University
2024
Tianjin Medical University
2021-2023
Tianjin Medical University Cancer Institute and Hospital
2021
China Telecom
2016
China Telecom (China)
2016
Abstract Interpreting the molecular mechanism of genomic variations and their causal relationship with diseases/traits are important challenging problems in human genetic study. To provide comprehensive context-specific variant annotations for biologists clinicians, here, by systematically integrating over 4TB genomic/epigenomic profiles frequently-used annotation databases from various biological domains, we develop a database, called VannoPortal. In general, database has following major...
Abstract Deciphering the fine-scale molecular mechanisms that shape genetic effects at disease-associated loci from genome-wide association studies (GWAS) remains challenging. The key avenue is to identify essential phenotypes mediate causal variant and disease under particular biological conditions. Therefore, integrating GWAS signals with context-specific quantitative trait (QTLs) (such as different tissue/cell types, states, perturbations) extensive would present important strategies for...
Telomere length (TL) shortening is a pivotal indicator of biological aging and associated with many human diseases. The genetic determinates TL have been widely investigated, however, most existing studies were conducted based on adult tissues which are heavily influenced by lifetime exposure. Based the analyses terminal restriction fragment (TRF) telomere, individual genotypes, gene expressions 166 healthy placental tissues, we systematically interrogate TL-modulated genes their potential...
Abstract Background Constipation was associated with incidence of dementia and cognitive decline. Laxatives are the mainstay constipation management commonly used among older populations for both treatment prevention constipation. However, association between use laxatives incident dementia, whether may modify effect genetic predisposition on remains unclear. Methods We applied 1:3 propensity score matching to balance baseline characteristics laxative users versus non-users reduce potential...
Abstract Microbiota have an important function in shaping and priming neonatal immunity, although the cellular molecular mechanisms underlying these effects remain obscure. Here we report that prenatal antibiotic exposure causes significant elevation of group 2 innate lymphoid cells (ILC2s) lungs, both cell numbers functionality. Downregulation type 1 interferon signaling ILC2s due to diminished production microbiota-derived butyrate represents mechanism. Mice lacking receptor GPR41 ( Gpr41...
CCCTC-binding factor (CTCF) is a transcription regulator with complex role in gene regulation. The recognition and effects of CTCF on DNA sequences, chromosome barriers, enhancer blocking are not well understood. Existing computational tools struggle to assess the regulatory potential CTCF-binding sites their impact chromatin loop formation. Here we have developed deep-learning model, DeepAnchor, accurately characterize binding using high-resolution genomic/epigenomic features. This has...
Context-specific activities of transcription regulators (TRs) in the nucleus modulate spatiotemporal gene expression precisely. Using largest ChIP-seq data and chromatin loops human K562 cell line, we initially interrogated TR cooperation 3D via a graphical model revealed many known novel TRs manipulating context-specific pathways. To explore across broad tissue/cell types, systematically leveraged large-scale open profiles, computational footprinting, high-resolution interactions to...
Acoustic electrocardiography (ACG) is a new non-invasive test that combines the visualization of traditional ECG waveforms and heart-generated sound to jointly assess cardiac function pathology. However, ACG equipment limited by technology suffers from problems such as inconvenience inaccuracy. In recent years, with development artificial intelligence technology, some newly developed wearable single-lead devices have appeared, which applications in fields heart failure coronary disease....
Abstract Despite advances in annotating and interpreting human genetic variants, existing methods to distinguish deleterious/pathogenic from neutral variants still inadequately capture the nuanced impact of on fitness disease susceptibility. In this study, we introduced a new deep learning framework, FIND model, by stratifying into refined categories based selection pressures derived allele frequency. demonstrated superior performance over genome-wide methods, delivering enhanced resolution...
Totally implanted venous access ports (TIVAPs), which are typically used in oncological chemotherapy and parenteral nutritional support, convenient safe, thus offer patients a higher quality of life. However, insertion or removal the device requires minor surgical operation. Long‑term complications (>30 days post insertion), such as catheter migration, catheter‑related thrombosis infection, major reasons for TIVAP associated with number factors body mass index hemoglobin count. Since...
With the popularity of network, P2P-based Video on Demand (VoD) has become one main services in Internet. However, due to huge amount videos, how access video quickly is important since it affects subscriber's experience. In this paper, a popularity-driven storing model proposed fasten discovery for centralized P2P-VoD system. All videos are stored binary tree server according their popularities. Experimental results show that scheme works well terms delay and resource utilization.
Abstract Telomere length (TL) shortening is a pivotal indicator of biological aging and associated with many human diseases. The genetic determinates TL have been widely investigated, however, most existing studies were conducted based on adult tissues which are heavily influenced by lifetime exposure. Based the analyses terminal restriction fragment (TRF) telomere, individual genotypes, gene expressions 166 healthy placental tissues, we systematically interrogated TL-modulated genes their...
Abstract Purpose Age-related macular degeneration (AMD), cataract, and glaucoma are leading causes of blindness worldwide. Previous genome-wide association studies (GWASs) have revealed a variety susceptible loci associated with age-related ocular disorders, yet the genetic pleiotropy causal genes across these diseases remain poorly understood. This study aims to identify pleiotropic among AMD, glaucoma. Methods We leveraged large-scale observational data from disease GWASs UK Biobank (UKBB)...