A5019049860- Inflammatory mediators and NSAID effects
- Cardiac Fibrosis and Remodeling
- Chemotherapy-induced cardiotoxicity and mitigation
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- Signaling Pathways in Disease
- Adipose Tissue and Metabolism
- Adenosine and Purinergic Signaling
- NF-κB Signaling Pathways
- Hormonal Regulation and Hypertension
- Apelin-related biomedical research
- Cardiac Ischemia and Reperfusion
- Steroid Chemistry and Biochemistry
- Retinal Development and Disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
- Autophagy in Disease and Therapy
- Sodium Intake and Health
- Pharmacological Effects of Natural Compounds
- Stroke Rehabilitation and Recovery
- Occupational and environmental lung diseases
- Inflammasome and immune disorders
- Monoclonal and Polyclonal Antibodies Research
- Liver physiology and pathology
Tianjin Medical University
2017-2024
Tianjin Medical University General Hospital
2024
Shanghai Institutes for Biological Sciences
2014-2018
Chinese Academy of Sciences
2014-2018
Center for Excellence in Molecular Cell Science
2016-2017
Nanjing Medical University
2017
Tennessee Valley Authority
2017
Ruijin Hospital
2017
University of Chinese Academy of Sciences
2016-2017
Tsukuba International University
2017
Chemotherapeutic agents, such as doxorubicin (DOX), may cause cardiomyopathy, even life-threatening arrhythmias in cancer patients. Ferroptosis-an iron-dependent oxidative form of programmed necrosis, plays a pivotal role DOX-induced cardiomyopathy (DIC). Prostaglandins (PGs) are bioactive signaling molecules that profoundly modulate cardiac performance both physiologic and pathologic conditions. Here, we found PGE2 production its E-prostanoid 1 receptor (EP1) expression were upregulated...
Research Article27 March 2017Open Access Transparent process Niacin ameliorates ulcerative colitis via prostaglandin D2-mediated D prostanoid receptor 1 activation Juanjuan Li Department of Gastroenterology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School Medicine, Shanghai, China Key Laboratory Food Safety Research, Institute for Nutritional Sciences, Institutes Biological Chinese Academy Search more papers by this author Deping Kong Qi Wang Wei Wu Yanping Tang Tingting...
Research Article15 January 2018Open Access Source DataTransparent process CRTH2 promotes endoplasmic reticulum stress-induced cardiomyocyte apoptosis through m-calpain Shengkai Zuo Department of Pharmacology, Key Laboratory Immune Microenvironment and Disease (Ministry Education), School Basic Medical Sciences, Tianjin University, Tianjin, China Food Safety Research, Institute for Nutritional Shanghai Institutes Biological Chinese Academy Shanghai, Search more papers by this author Deping...
The kinetic participation of macrophages is critical for inflammatory resolution and recovery from myocardial infarction (MI), particularly with respect to the transition M1 M2 phenotype; however, underlying mechanisms are poorly understood. In this study, we found that deletion prostaglandin (PG) D2 receptor subtype 1 (DP1) in retarded polarization, antiinflammatory cytokine production, different models, including MI model. DP1 up-regulated proinflammatory genes expression via JAK2/STAT1...
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by progressive pulmonary artery (PA) remodeling. T helper 2 cell (Th2) immune response involved in PA remodeling during PAH progression. Here, we found that CRTH2 (chemoattractant receptor homologous molecule expressed on Th2 cell) expression was up-regulated circulating CD3+CD4+ cells patients with idiopathic and rodent models. disruption dramatically ameliorated different mouse deficiency suppressed...
An appropriate inflammatory response is necessary for cardiac healing after acute myocardial infarction (MI). Resolvin E1 (RvE1) an anti-inflammatory and pro-resolution lipid mediator derived from eicosapentaenoic acid. Here we have investigated the effects of RvE1 on recovery function MI in mice.Acute was induced by surgical ligation left anterior descending artery male C57BL/6 mice. (5 ng·g-1 ·day-1 ; i.p.) given to mice at different times following MI. Cardiac monitored transthoracic...
Gluconeogenesis is drastically increased in patients with type 2 diabetes and accounts for fasting plasma glucose concentrations. Circulating levels of prostaglandin (PG) F2α are also markedly elevated diabetes; however, whether how PGF2α regulates hepatic metabolism remain unknown. Here, we demonstrated that receptor (F-prostanoid [FP]) was upregulated the livers mice upon fasting- diabetic stress. Hepatic deletion FP suppressed fasting-induced gluconeogenesis, whereas overexpression...
Natural killer (NK) cells exhibit antifibrotic properties in liver fibrosis (LF) by suppressing activated hepatic stellate cell (HSC) populations. Prostaglandin E2 (PGE2) plays a dual role innate and adaptive immunity. Here, we found that E-prostanoid 3 receptor (EP3) was markedly downregulated NK from mice patients with cirrhosis. cell–specific deletion of EP3 aggravated fibrogenesis mouse models LF. Loss selectively reduced the cytotoxicity CD27+CD11b+ double positive (DP) subset against...
l-Arginine and l-arginine-metabolizing enzymes play important roles in the biology of some types myeloid cells, including macrophage myeloid-derived suppressor cells. In this study, we found evidence that arginase 1 (Arg1) is required for differentiation mouse dendritic cells (DCs). Expression Arg1 was robustly induced during monocyte-derived DC differentiation. Ectopic expression significantly promoted monocytic a granulocyte-macrophage colony-stimulating factor culture system also...
Abstract Two distinct monocyte (Mo)/macrophage (Mp) subsets (Ly6C low and Ly6C high ) orchestrate cardiac recovery process following myocardial infarction (MI). Prostaglandin (PG) E 2 is involved in the Mo/Mp-mediated inflammatory response, however, role of its receptors Mos/Mps healing remains to be determined. Here we show that pharmacological inhibition or gene ablation Ep3 receptor mice suppresses accumulation infarcted hearts. deletion markedly attenuates after MI by reducing...
Blood pressure often rises with aging, but exact mechanisms are still not completely understood. With the level of proinflammatory cytokines increases in T lymphocytes. Prostaglandin D2, a proresolution mediator, suppresses Type 1 helper (Th1) through D-prostanoid receptor (DP1). In this study, we aimed to investigate role prostaglandin D2/DP1 axis cells on age-related hypertension.To clarify physiological and pathophysiological roles DP1 peripheral blood samples were collected from young...
Abstract Aerobic training (AT), an effective form of cardiac rehabilitation, has been shown to be beneficial for repair and remodeling after myocardial infarction (MI). The p300/CBP‐associated factor (PCAF) is one the most important lysine acetyltransferases involved in various biological processes. However, role PCAF AT AT‐mediated post‐MI not determined. Here, we found that protein level was significantly increased MI, while blocked increase PCAF. markedly improved mice MI by reducing...
Niacin is a well established drug used to lower cholesterol and prevent cardiovascular disease events. However, niacin also causes cutaneous flushing side effects due release of the proresolution mediator prostaglandin D2 (PGD2). Recent randomized clinical trials have demonstrated that addition with laropiprant [a PGD2 receptor subtype 1 (DP1) blocker] statin-based therapies does not significantly decrease risk events, but increases serious adverse Here, we tested whether, how, beneficial on...
Prostaglandin E 2 (PGE ) is an important lipid mediator of inflammation. However, whether and how PGE regulates hepatic cholesterol metabolism remains unknown. We found that expression the receptor, prostanoid receptor 3 (EP3) remarkably increased in hepatocytes response to hyperlipidemic stress. Hepatocyte‐specific deletion EP3 ( hep–/– results hypercholesterolemia augments diet‐induced atherosclerosis low‐density lipoprotein knockout Ldlr –/– mice. Cholesterol 7α‐hydroxylase (CYP7A1)...
To investigate whether rs12731181 (A→G) interrupted miR-590-3p-mediated suppression of the prostaglandin F2α receptor (FP) and it is associated with essential hypertension in Chinese population.We found that miR-590-3p regulates human FP gene expression by binding to its 3'-untranslated region. altered affinity between region target, thus reducing expression, which, turn, enhanced receptor-mediated contractility vascular smooth muscle cells. Overexpression augmented tone elevated blood...
Autologous adipose-derived stromal cells (ASCs) offer great promise as angiogenic cell therapy for ischemic diseases. Because of their limited self-renewal capacity and pluripotentiality, the therapeutic efficacy ASCs is still relatively low. Thromboxane has been shown to play an important role in maintenance vascular homeostasis. However, little known about effects thromboxane on ASC-mediated angiogenesis.To explore thromboxane-prostanoid receptor (TP) mediating vivo.ASCs were prepared from...
Abstract Prostanoids are endogenous lipid bioactive mediators that play essential roles in physiological processes such as glucocorticoid secretion. Here, it is found the thromboxane (Tx)A 2 receptor (TP) highly expressed adrenal cortex of mice. Both global and adrenocortical‐specific deletion TP lead to increased adiposity mice by elevating corticosterone synthesis. Mechanistically, increases phosphorylation steroidogenic acute regulatory protein (StAR) synthesis cortical cells suppressing...
Renal fibrosis is a common pathological hallmark of chronic kidney disease (CKD). sympathetic nerve activity elevated in patients and experimental animals with CKD contributes to renal interstitial obstructive nephropathy. However, the mechanisms underlying overactivation remain unknown. Norepinephrine (NE), main neurotransmitter, was found promote TGF-β1-induced epithelial-mesenchymal transition (EMT) fibrotic gene expression human proximal epithelial cell line HK-2. Using both genetic...
The present study establishes a compendium of genetic evidence that support antineoplastic-induced cardiovascular risk.