A5033114653- Wound Healing and Treatments
- Planarian Biology and Electrostimulation
- Spaceflight effects on biology
- Cancer, Stress, Anesthesia, and Immune Response
- Epigenetics and DNA Methylation
- Liver physiology and pathology
- Electromagnetic Fields and Biological Effects
- Ion Transport and Channel Regulation
- Apelin-related biomedical research
- GDF15 and Related Biomarkers
- Mesenchymal stem cell research
- Bone health and osteoporosis research
- Hepatocellular Carcinoma Treatment and Prognosis
- Chronic Kidney Disease and Diabetes
Tianjin Medical University
2019-2025
Impaired wound healing is commonly encountered in patients with diabetes mellitus, which may lead to severe outcomes such as amputation, if untreated timely. Macrophage plays a critical role the process including resolution phase. Although magnetic therapy known improve microcirculation, its effect on remains uncertain. In present study, we found that 0.6 T static field (SMF) significantly accelerated closure and elevated reepithelialization revascularization diabetic mice. Notably, SMF...
Gain-of-function mutations of Notch2 cause the rare autosomal dominant disorder known as Hajdu–Cheney syndrome (HCS). Most patients with HCS develop congenital heart disease; however, precise mechanisms remain elusive. Here, a murine model expressing human intracellular domain (hN2ICD) in cardiomyocytes (hN2ICD-Tg CM ) was generated and mice spontaneously developed ventricular diastolic dysfunction preserved ejection fraction cardiac hypertrophy. Ectopic hN2ICD expression promoted...
Abstract Background Osteoporosis is a common metabolic bone disease without effective treatment. Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to differentiate into multiple cell types. Increased adipogenic differentiation or reduced osteogenic of BMSCs might lead osteoporosis. Whether static magnetic fields (SMFs) influence adipo-osteogenic balance remains unknown. Methods The effects SMFs on lineage and development osteoporosis were determined by various biochemical...
Despite advances in understanding hypertension's genetic structure, how noncoding variants influence it remains unclear. Studying their interaction with DNA methylation is crucial to deciphering this complex disease's mechanisms.
Renal fibrosis is a common pathological hallmark of chronic kidney disease (CKD). sympathetic nerve activity elevated in patients and experimental animals with CKD contributes to renal interstitial obstructive nephropathy. However, the mechanisms underlying overactivation remain unknown. Norepinephrine (NE), main neurotransmitter, was found promote TGF-β1-induced epithelial-mesenchymal transition (EMT) fibrotic gene expression human proximal epithelial cell line HK-2. Using both genetic...
The liver possesses a remarkable regenerative capacity in response to injuries or viral infections. Various growth factors and cytokines are involved regulating regeneration. Prostaglandin D 2 , pro-resolution lipid mediator, is the most abundant hepatic prostanoid. However, role of prostaglandin injury-induced regeneration remains unclear.
Impaired wound healing is commonly encountered in patients with diabetes mellitus, which may lead to severe outcomes such as amputation, if untreated timely. Macrophage plays a critical role the process including resolution phase. Although magnetic therapy known improve microcirculation, its effect on remains uncertain. In present study, model of diabetic mice was used prove static field (SMF) process. The positive SMF macrophage polarization observed areas db/db by immunofluorescence...