A5016944953- Liver Disease and Transplantation
- Immune Cell Function and Interaction
- Liver physiology and pathology
- GDF15 and Related Biomarkers
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
Tianjin Medical University
2022-2025
Natural killer (NK) cells exhibit antifibrotic properties in liver fibrosis (LF) by suppressing activated hepatic stellate cell (HSC) populations. Prostaglandin E2 (PGE2) plays a dual role innate and adaptive immunity. Here, we found that E-prostanoid 3 receptor (EP3) was markedly downregulated NK from mice patients with cirrhosis. cell–specific deletion of EP3 aggravated fibrogenesis mouse models LF. Loss selectively reduced the cytotoxicity CD27+CD11b+ double positive (DP) subset against...
Gain-of-function mutations of Notch2 cause the rare autosomal dominant disorder known as Hajdu–Cheney syndrome (HCS). Most patients with HCS develop congenital heart disease; however, precise mechanisms remain elusive. Here, a murine model expressing human intracellular domain (hN2ICD) in cardiomyocytes (hN2ICD-Tg CM ) was generated and mice spontaneously developed ventricular diastolic dysfunction preserved ejection fraction cardiac hypertrophy. Ectopic hN2ICD expression promoted...