A5011517352- Organ Transplantation Techniques and Outcomes
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Hepatitis B Virus Studies
- Cytomegalovirus and herpesvirus research
- Liver Disease and Transplantation
- Diabetes Management and Research
- Mycobacterium research and diagnosis
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Organ Donation and Transplantation
- Tissue Engineering and Regenerative Medicine
- Hematopoietic Stem Cell Transplantation
- Anesthesia and Neurotoxicity Research
- Advanced biosensing and bioanalysis techniques
- Nutritional Studies and Diet
- Analytical Chemistry and Sensors
- Heme Oxygenase-1 and Carbon Monoxide
- MicroRNA in disease regulation
- Hepatitis C virus research
- Transplantation: Methods and Outcomes
- Cancer-related molecular mechanisms research
Tianjin Medical University
2014-2024
Tianjin First Center Hospital
2014-2024
Nankai University
2019-2024
Kings Health Partners
2024
King's College London
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
National Health and Family Planning Commission
2022
Society of Critical Care Medicine
2020
Shanghai Clinical Research Center
2019
Tianjin University
2014
// Shi-Peng Li 1, * , Hai-Xu Xu 3, Yao Yu Jin-Dan He Zhen Wang 1 Yan-Jie Chang-Ying 3 Hai-Ming Zhang 2 Rong-Xin 4 Jian-Jun Zhi Zhong-Yang Shen First Central Clinical College, Tianjin Medical University, Tianjin, P.R. China Oriental Organ Transplant Center of Hospital, Key Laboratory Transplantation P.R.China Department Immunology, Cellular and Molecular Immuno Microenvironment Disease the Educational Ministry, Immunology Inflammation, Immune Diseases Ministry China, Basic These authors have...
Abstract The continuous evolution of SARS-CoV-2, particularly the emergence BA.2.86/JN.1 lineage replacing XBB lineages, necessitates re-evaluation current vaccine compositions. Here, we provide a comprehensive analysis humoral immune response to and JN.1 human exposures, emphasizing need for JN.1-lineage-based boosters. We demonstrate antigenic distinctiveness lineages in SARS-CoV-2-naive individuals but not those with prior vaccinations or infections, infection elicits superior plasma...
Peripheral nerve injuries may result in severe long-gap interruptions that are challenging to repair. Autografting is the gold standard surgical approach for repairing but can prominent donor-site complications. Instead, imitating native neural microarchitecture using synthetic conduits expected offer an alternative strategy improving regeneration. Here, we designed composed of high-resolution anisotropic microfiber grid-cordes with randomly organized nanofiber sheaths interrogate positive...
The cyclooxygenase2 (COX-2) enzyme catalyzes the first step of prostanoid biosynthesis, and is known for its crucial role in pathogenesis several inflammatory diseases including type 2 diabetes mellitus (T2DM). Although a variety studies revealed that COX-2 played IL-1β induced β cell dysfunction, molecular mechanism remains unclear. Here, using cDNA microarray silico analysis, we demonstrated responses were upregulated human T2DM islets compared with non-diabetic (ND) islets. expression was...
Continuous in vivo monitoring (CIVM) of pH value is essential for personalized medicine, as many diseases are closely related to acid-base imbalances. However, conventional meters limited their ability perform CIVM due excessive blood consumption, large device volume, frequent calibration, and inadequate real-time monitoring. There thus an urgent need a portable method value. To address this need, we propose minimally invasive, continuous solution the form implantable microneedle sensor...
Rapid, low-cost and high-specific diagnosis based on nucleic acid detection is pivotal in both detecting controlling various infectious diseases, effectively curbing their spread. Moreover, the analysis of circulating DNA whole blood has emerged as a promising noninvasive strategy for cancer monitoring. Although traditional methods are reliable, time-consuming intricate processes restrict application rapid field assays. Consequently, an urgent emphasis point-of-care testing (POCT) acids...
Variations in the activities of Cytochrome P450s are one major factors responsible for inter-individual differences drug clearance rates, which may cause serious toxicity or inefficacy therapeutic drugs. Various mRNA level is key different activity P450 genes. Although both genetic and environmental regulators gene expression have been widely investigated, few studies evaluated functional importance cis- trans-regulatory modulation variations In this study, we measured levels seven genes...
Capecitabine (CAP) is now widely used in the comprehensive treatment of digestive system tumors. Some clinical observations have shown that CAP may immunosuppressive effects, but there still a lack clear experimental verification. In this study, different doses were administered to normal mice by gavage. Our results confirmed did not cause myelosuppression bone marrow tissue; selectively reduced proportion T cells and concentration related pro-inflammatory cytokines, while it increased...
Capecitabine (CAP) is a classic antimetabolic drug and has shown potential antirejection effects after liver transplantation (LT) in clinical studies. Our previous study showed that metronomic CAP can cause the programmed death of T cells by inducing oxidative stress healthy mice. Ferroptosis, newly defined non-apoptotic cell occurs response to iron overload lethal levels lipid peroxidation, an important mechanism which induces death. Therefore, ferroptosis may also play role CAP-induced...
In this study, we determined whether multilineage-differentiating stress-enduring (Muse) cells exist in rat bone marrow and elucidated their effects on protection against the injury of intestinal epithelial associated with inflammation. Rat Muse were separated from mesenchymal stem (BMMSCs) by trypsin-incubation stress. The group maintained characteristics BMMSCs; however, there high positive expression levels stage-specific embryonic antigen-3 (SSEA-3; 75.6 ± 2.8%) antigen-1 (SSEA-1; 74.8...
Dendritic cell (DC)‑based cancer immunotherapy requires an immunogenic tumor‑associated antigen and effective therapeutic strategy. Glypican 3 (GPC3) is a valuable diagnostic marker potential target in hepatocellular carcinoma (HCC). The present study investigated whether DCs transduced with the GPC3 gene (DCs‑GPC3) co‑cultured autologous cytokine‑induced killer cells (CIKs) may induce marked specific immune response against GPC3‑expressing HCC vitro vivo. Human were transfected green...
Abstract Aim To explore the effects of protein phosphatase 2 regulatory subunit B''Alpha ( PPP2R3A ) on proliferation and migration liver cancer cells. Methods Expression in tumor tissues hepatocellular carcinoma (HCC) patients was detected by immunohistochemistry western blotting. In two cell lines (HepG2 HuH7), expression silenced then overexpression with lentiviral vectors, knockdown or proliferation, cycle, migration, invasion HCC cells were determined vitro. a xenograft model nude mice,...
Liver injury is a serious clinical syndrome that characterized by inflammatory response. Engeletin known to have anti-inflammatory activity. However, the effects of engeletin on liver remain unclear. We aimed assess protective effect Lipopolysaccharide (LPS)/d-galactosamine (D-gal)-induced in mice. was administered intraperitoneally 1 h before and 12 after LPS/D-gal treatment. The results showed treatment LPS/D-gal-induced mice significant effect, as confirmed attenuation histopathologic...
Biliary complications are currently one of the leading causes liver failure and patient death after transplantation need to be solved urgently. ischemia-reperfusion injury (IRI) is important biliary complications. IL-22 has a protective effect on hepatitis diseases, its safety efficacy in treatment have also been proved human clinical experiments. Furthermore, multiple studies confirmed that promotes proliferation repair epithelial cells various organs. Still, function bile duct not...
To investigate the effects of heme oxygenase-1 (HO-1)-modified bone marrow mesenchymal stem cells (BMMSCs) on microcirculation and energy metabolism hepatic sinusoids following reduced-size liver transplantation (RLT) in a rat model.BMMSCs were isolated cultured vitro using an adherent method, then transduced with HO-1-bearing recombinant adenovirus to construct HO-1/BMMSCs. A acute rejection model 50% RLT was established two-cuff technique. Recipients divided into three groups based...
Somatostatin analog improves survival in patients with advanced hepatocellular carcinoma by interacting its specific receptor 2 and 5. However, expression of somatostatin (SSTR) operable HCC is still unclear. In this study, we analyzed the SSTR-2 -5 HBV-related compared clinicopathological features follow-up data.Seventy six were enrolled. was investigated QPCR immunohistochemistry all samples. Furthermore, association between gene analyzed.Compared to surrounding cirrhotic tissues, mRNA...
BACKGROUND:Studies have shown that normothermic machine perfusion (NMP) exerts a significant protective role for donations after cardiac death (DCD) livers and verified the effects of NMP in preservation, repair, preoperative assessment human donor livers. The objective this study was to verify effectiveness stability system by splitting pig preservation. MATERIAL AND METHODS:Four healthy Ba-Ma miniature pigs were used. harvested, then connected split indexes during recorded, serological...