A5101400490- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Clinical Nutrition and Gastroenterology
- Zebrafish Biomedical Research Applications
- Organ Donation and Transplantation
- Heme Oxygenase-1 and Carbon Monoxide
Guangzhou Medical University
2025
Tianjin Medical University
2016-2021
Tianjin First Center Hospital
2016-2021
Tianjin University
2016
Brain organoids have been proposed as suitable human brain model candidates for a variety of applications. However, the lack appropriate maturation limits transferability such functional tools. Here, we present method to facilitate neuronal by integrating astrocyte-secreted factors into hPSC-derived 2D and 3D neural culture systems. We demonstrate that protein- nutrient-enriched astrocyte-conditioned medium (ACM) accelerates differentiation with enlarged layer overproduction deep-layer...
Abstract Ischemia‐reperfusion (I/R) injury causes cellular dysfunction and a series of immune or apoptotic reactions. Bach1 is mammalian transcription factor that represses Hmox1, which encodes heme oxygenase‐1 (HO‐1) can degrade into free iron, carbon monoxide, biliverdin, to play an important role in antioxidant, anti‐inflammatory, antiapoptotic activities. MicroRNAs (miRNAs) be found variety eukaryotic cells viruses, class noncoding small RNAs are encoded by endogenous genes. The aims...
The purpose of this study is to explore whether normothermic machine perfusion (NMP) preservation superior cold during reduced-size liver transplantation (RSLT) in pigs. Twenty-four healthy Ba-Ma mini pigs were used (aged >13 months; weight 25-35 kg; regardless sex). animals randomized into 2 groups. In group A (NMP), donor livers harvested without warm ischemia time and heartbeats then connected the NMP system reduce livers' size under condition. B (University Wisconsin [UW] solution),...
BACKGROUND:Studies have shown that normothermic machine perfusion (NMP) exerts a significant protective role for donations after cardiac death (DCD) livers and verified the effects of NMP in preservation, repair, preoperative assessment human donor livers. The objective this study was to verify effectiveness stability system by splitting pig preservation. MATERIAL AND METHODS:Four healthy Ba-Ma miniature pigs were used. harvested, then connected split indexes during recorded, serological...
BACKGROUND:Normothermic machine perfusion (NMP) preservation is superior to cold during reduced-size liver transplantation (RSLT) in pigs. However, the mechanism of this protective effect has not been explained. We aimed compare effects NMP with that (CS) protecting against ischemia-reperfusion injury (IRI) RSLT MATERIAL AND METHODS:Twenty-four healthy Bama miniature pigs were randomized into 2 groups: 1) group which donor livers harvested without warm ischemia time and cardiac activity...
Objective To summarize the peri-operative management experience of swine orthotopic liver transplantation. Methods From September 2013 to August 2016, 62 transplantations (LT) were performed with 124 Bama mini-pigs, including 30 cases standard LT, 10 split 11 donation after cardiac death (DCD) 5 extracorporeal membrane oxygenation (ECMO) repaired DCD LT and 6 normothermic machine perfusion (NMP) LT. Results For all pigs, 3 underwent tracheotomy failed tracheal intubation....
Objective: To evaluate the effect of transfusion-free techniques on prognosis liver transplant patients. Methods: The recipients adult transplantation at Tianjin First Central Hospital from August to December 2019 were included in clinical observation. Liver without allogeneic blood transfusion was performed through anesthesia management such as acute hemodilution or phlebotomy volume replacement,maintaining decreased baseline central venous pressure and cell saver. According actual...