The incidence of graft fibrosis is elevated following pediatric liver transplantation (pLT) and influenced by cold ischemic time (CIT). Myosin light chain 9 (MYL9), a member the myosin family, could act on hepatic stellate cells (HSCs) induce transition to active phase. We hypothesized that injury stimulate MYL9 expression lead fibrosis. tested hypothesis analyzing multi-omics data from human protocol biopsy samples 2 years after transplant, performing rat LT with different CIT conducting in...

Post-liver transplantation-Burkitt lymphoma (PLT-BL) is an aggressive and life-threatening complication after pediatric liver transplantation. The research on the disease characteristics, treatment, prognosis of PLT-BL limited. A retrospective, observational study was performed to analyze outcomes in 12 transplant (LT) recipients diagnosed with PLT-BL. medium time from transplantation diagnosis 32.71 months (range, 25.78-37.85 months). All patients (100%) tested positive for EBV viremia at...

Abstract Based on the Sen spacetime, orbital energy and angular momentum are calculated, solution for motion of a test particle derived to second post‐Newtonian order. The effect black hole's charge periastron advance period is obtained. In particular, it found that has an influence perihelion precession at both first orders, whereas its confined solely Finally, star S2 used constrain our model value 0.51.

Adipose‑derived mesenchymal stromal cells (ADSCs) possess a multilineage potential and immunoregulatory properties, may have great in autologous cell‑based technologies. The aim of the present study was to investigate how age patients with benign end‑stage liver disease affected biological functional characteristics ADSCs, which is important for increasing effectiveness cell therapy. ADSCs were obtained cultured from three distinct groups: Infant, adult elderly. Cell immunophenotypic...

Abstract We retrospectively analyzed 252 patients with end‐stage liver disease who had undergone LDLT from January 2009 to September 2015. Of these, 25 a GRWR of <2.0% (Group A), 204 ≥2.0% or <4.0% B), and 23 ≥4.0% C). The three groups demonstrated similar characteristics, except for recipient age BMI . overall 1‐, 2‐, 3‐year graft survival rates were 95.1%, 93.5%, respectively. However, among the groups, at 1 year, 2 years, 3 years significantly different ( P = .0009). Hepatic artery...

The purpose of this study is to explore whether normothermic machine perfusion (NMP) preservation superior cold during reduced-size liver transplantation (RSLT) in pigs. Twenty-four healthy Ba-Ma mini pigs were used (aged >13 months; weight 25-35 kg; regardless sex). animals randomized into 2 groups. In group A (NMP), donor livers harvested without warm ischemia time and heartbeats then connected the NMP system reduce livers' size under condition. B (University Wisconsin [UW] solution),...

This study aimed to explore whether serum CXCL8 concentration can be used as a noninvasive marker of subclinical rejection (SCR) after pediatric liver transplantation (pLT).Firstly, RNA sequencing (RNA-seq) was performed on 22 protocol biopsy samples. Secondly, several experimental methods were verify the RNA-seq results. Finally, clinical data and samples 520 LT patients in Department Pediatric Transplantation Tianjin First Central Hospital from January 2018 December 2019 collected.RNA-seq...

BACKGROUND:Studies have shown that normothermic machine perfusion (NMP) exerts a significant protective role for donations after cardiac death (DCD) livers and verified the effects of NMP in preservation, repair, preoperative assessment human donor livers. The objective this study was to verify effectiveness stability system by splitting pig preservation. MATERIAL AND METHODS:Four healthy Ba-Ma miniature pigs were used. harvested, then connected split indexes during recorded, serological...

BACKGROUND:Normothermic machine perfusion (NMP) preservation is superior to cold during reduced-size liver transplantation (RSLT) in pigs. However, the mechanism of this protective effect has not been explained. We aimed compare effects NMP with that (CS) protecting against ischemia-reperfusion injury (IRI) RSLT MATERIAL AND METHODS:Twenty-four healthy Bama miniature pigs were randomized into 2 groups: 1) group which donor livers harvested without warm ischemia time and cardiac activity...

Use of livers infected with Clonorchis sinensis as donor organs for transplantation is controversial because the potential associated risks. The low availability at Tianjin First Center Hospital since 2003 prompted us to undertake cadaveric liver in 14 patients using C. sinensis. None donors had been diagnosed fluke infection before organ procurement, and none them was there laboratory evidence abnormal function. After harvested preserved, dead flukes were found bile each donor; subsequent...

Th17 and imbalance of Treg/Th17 might be one the mechanisms acute rejection. We aim to explore role Th17s in balance rejection after LT children diagnosed with BA. The ratios Treg peripheral blood were detected by flow cytometry pre-LT, post-LT, when occurred. proportion was higher before transplantation than at 2 weeks 1 month transplantation, no statistical difference between month. However, proportions lower pediatric recipients healthy controls. Tregs anti-rejection treatment control...

Biliary atresia (BA) is the most common indication for pediatric liver transplantation, and biliary stricture (BS) remains an Achilles’ heel living donor transplantation (LDLT). We investigated impact of different ischemia times on BS after LDLT in patients with BA. retrospectively analyzed (<18 y) BA who underwent between January 2016 December 2020. Cases hepatic artery thrombosis, bile leakage, early (<2 wk), death (<3 mo) were excluded. In all, 572 cases included. A total 26...

Bone marrow mesenchymal stem cells (BM‑MSCs) regulate the balance between regulatory T (Tregs) and helper 17 (Th17) cells. However, role of different factors on BM‑MSCs‑mediated regulation Treg/Th17 is unknown. BM‑MSCs CD4+ lymphocytes were co‑cultured with various treatments. The ratio was calculated expression cytokines measured. found to have a proliferative effect Th17 at basal concentration 2‑fold increase in number BM‑MSCs. when used increased 4‑fold, they had an inhibitory Tregs...

In this paper, we present the Global Multimedia Deepfake Detection held concurrently with Inclusion 2024. Our aims to detect automatic image and audio-video manipulations including but not limited editing, synthesis, generation, Photoshop,etc. challenge has attracted 1500 teams from all over world, about 5000 valid result submission counts. We invite top 20 their solutions challenge, which 3 are awarded prizes in grand finale. of two tracks, boost research work field forgery detection. The...

Abstract Background Posttransplant lymphoproliferative disease (PTLD) is a serious complication after pediatric liver transplantation (pLT), which may lead to death. 18 F‐FDG PET/CT rarely considered in PTLD pLT and lacks clear diagnostic guidelines, especially the differential diagnosis of nondestructive PTLD. The aim this study was find quantifiable index identify pLT. Methods This retrospective collected data patients who underwent pLT, postoperative lymph node biopsy, at Tianjin First...

Abstract Aim The aim of this study was to gain comprehensive insight into the quality life parental living liver donors after donation. Background Several studies reported good with SF‐36 scale. Care demand from recipient and responsibility being parent might make a difference in donors' personal experienced transplantation surgery. Methods It is cross‐sectional study. demographics, clinical data post‐donation complications were obtained. Quality assessed using Medical Outcomes Study Life...

Subclinical rejection (SCR) is a common injury in protocol biopsy after pediatric liver transplantation (pLT), but its effect on the recipient not clearly understood. We herein investigated incidence and risk factors involved SCR analyzed relationship between allograft fibrosis (AF).We retrospectively reviewed results from 507 children May 2013 2019, 352 patients underwent 2 years pLT, 203 5 48 both pLT.The of 5-year group was higher than that 2-year (20.2% vs.13.4%, respectively, p = .033)....