A5101459382- Liver physiology and pathology
- Inflammatory Bowel Disease
- RNA Research and Splicing
- Immunodeficiency and Autoimmune Disorders
- DNA Repair Mechanisms
- Cell death mechanisms and regulation
- Gut microbiota and health
- Genomics and Chromatin Dynamics
- Advanced biosensing and bioanalysis techniques
- Galectins and Cancer Biology
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Wnt/β-catenin signaling in development and cancer
- MicroRNA in disease regulation
- Bacterial Genetics and Biotechnology
- Monoclonal and Polyclonal Antibodies Research
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Systemic Lupus Erythematosus Research
- DNA and Nucleic Acid Chemistry
- Escherichia coli research studies
- Echinoderm biology and ecology
Ningbo University
2024
Prometheus Biosciences (United States)
2021
Wuhan University
2019
Tianjin First Center Hospital
2017-2019
Tianjin Medical University
2017-2019
Nankai University
2018
Henan Provincial People's Hospital
2014
Guangzhou Medical University
2011
The genetic variations in NBS1 gene have been reported to be associated with cancer risk. polymorphisms 3′-untranslated region (3′-UTR) of might affect gene's function and thus contribute susceptibility. We hypothesized that these are the lung In two independent case–control studies conducted Southern Eastern Chinese, we genotyped three tagSNPs (rs14448, rs13312986 rs2735383) Chinese then validated discovered association Chinese. No significant was observed for rs14448; only found...
A robust ATP aptasensor has been successfully constructed for intracellular imaging via the autonomous nonenzymatic cascaded hybridization chain reaction (Ca-HCR) circuit. This compact is easily assembled by integrating sensing module and amplification module, furtherly introduced selective adenosine triphosphate (ATP) assay sensitive tracking of varied expressions in living cells. The ATP-targeting aptamer-encoded can specifically recognize release initiator strand successively motivating...
Previous studies have demonstrated that the aberrant expression of Wnt5a occurs in atherosclerotic lesions. However, precise role pathogenesis atherosclerosis remains largely unknown. The present study was undertaken to determine whether RNA interference vivo by adenovirus (Ad)-mediated small interfering (siRNA) transfection is capable inhibiting progression atherosclerosis. Recombinant carrying siRNA targeting (Ad-Wnt5a siRNA) designed. Male apolipoprotein E-deficient (ApoE-/-) mice were...
Therapeutic drug monitoring (TDM) with measurement of serum and antidrug antibodies (ADAb) is used widely to confirm therapeutic exposure, rule out immunogenicity, optimize treatment biologics in patients inflammatory bowel diseases.1Feuerstein J.D. Nguyen G.C. Kupfer S.S. et al.American Gastroenterological Association Institute guideline on disease.Gastroenterology. 2017; 153: 827-834Abstract Full Text PDF PubMed Scopus (319) Google Scholar A recent genome-wide association study found the...
Adipose‑derived mesenchymal stromal cells (ADSCs) possess a multilineage potential and immunoregulatory properties, may have great in autologous cell‑based technologies. The aim of the present study was to investigate how age patients with benign end‑stage liver disease affected biological functional characteristics ADSCs, which is important for increasing effectiveness cell therapy. ADSCs were obtained cultured from three distinct groups: Infant, adult elderly. Cell immunophenotypic...
Chemotherapeutic drugs that induce DNA damage have the potential to kill cancer cells, but repair protects cells from damage‐induced cell death. Thus, eliminating is a approach overcome drug resistance. In this study, we observed gene expression of C‐terminal binding protein interacting (CTIP) was promoted by TNF‐α stimulation and prevented TNF‐α‐induced double‐strand breaks (DSBs) in genomes cervical cells. The putative miR‐130b targeted site within 3′ untranslated region (UTR) CTIP mRNA...