A5044344346- Organ Transplantation Techniques and Outcomes
- Anesthesia and Neurotoxicity Research
- Transplantation: Methods and Outcomes
- Anesthesia and Sedative Agents
- Cardiac Ischemia and Reperfusion
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Hydrogen's biological and therapeutic effects
- Intensive Care Unit Cognitive Disorders
- Pulmonary Hypertension Research and Treatments
- Mechanical Circulatory Support Devices
- Extracellular vesicles in disease
- Neurological Disease Mechanisms and Treatments
- Berberine and alkaloids research
- Pediatric Hepatobiliary Diseases and Treatments
- Metabolism and Genetic Disorders
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Acute Kidney Injury Research
- Neonatal Health and Biochemistry
- Circular RNAs in diseases
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
Tianjin First Center Hospital
2016-2025
Tianjin Medical University
2016-2025
Nankai University
2024
Changzhi Medical College
2024
Tianjin University
2022
Health Foundation
2015
Development Fund
2015
Deutsches Herzzentrum der Charité
2004-2012
Harbin Medical University
2005
Background . The neuronal injury and cognitive dysfunction after liver transplantation have severe effects on the prognosis life quality of patients. Accumulating evidence suggests that both exosomes pyroptosis could participate in hepatic ischemia-reperfusion (HIRI) play key roles death. However, link between HIRI awaits further investigation. Methods. After establishing rat models, we primarily studied role hippocampal cortical neuron through detecting NOD-like receptor protein 3 (NLRP3),...
The mechanism of nonalcoholic fatty liver susceptibility to ischemia/reperfusion (IR) injury has not been fully clarified. Caspase 6 is a critical regulator in innate immunity and host defense. We aimed characterize the specific role IR-induced inflammatory responses livers. Human samples were harvested from patients undergoing ischemia-related hepatectomy evaluate expression. mice model, we generated 6-knockout (Caspase 6KO) investigate cellular molecular mechanisms macrophage IR-stimulated...
Hepatocellular carcinoma (HCC) is widely recognized for its unfavorable prognosis. Increasing evidence has revealed that LGALS3 an essential function in initiating and developing several malignancies humans. Nevertheless, thorough analysis of the expression profile, clinical prognosis, pathway prediction, immune infiltration not been fully explored HCC.
Background: As a heterogeneous clinical syndrome, acute respiratory distress syndrome (ARDS) is caused by infection-associated inflammation with limited treatment options. Esketamine possesses antiinflammatory properties, and it effective in treating lung diseases. Objective: This study aimed to unveil the efficacy mechanism of esketamine ARDS. Methods: Lipopolysaccharide (LPS) widely used induce inflammatory response injury. The mice model ARDS this was established through inhalation LPS....
BACKGROUND Myocardial injury is common during liver transplantation and associated with poor outcomes. The development of a reliable prediction system for this type crucial reducing the incidence cardiac complications in children receiving living donor (LDLT). However, establishing practical myocardial biliary atresia remains considerable challenge. AIM To create validate nomogram model predicting who received LDLT. METHODS Clinical data from pediatric patients LDLT between November, 2019...
In Brief Background Acute kidney injury (AKI) impacts the survival of liver transplant recipients severely. To date, related mechanism and effective therapy have not been rigorously explored. The present study aimed to explore role p53-mediated autophagy in protective effect hydrogen-rich saline (HRS) on AKI after orthotropic transplantation (OLT). Methods Adult male Sprague-Dawley rats were randomly allocated into four groups: sham, OLT, OLT with HRS (6 ml/kg) pretreatment (HS), chloroquine...
Objective: We aimed to evaluate the adaptive growth and remodeling behavior of transplanted heart in pediatric heart-transplant recipients by comparing donor body surface area (BSA) cardiac dimensions during transplantation with corresponding parameters recipient over a period time. Methods: A retrospective review medical echocardiographic records 167 children (8.65 ± 5.98, median 9; range 0–17 years) who underwent orthotopic between 1987 March 2010 was done. Results: In first 30 days...
Living donor liver transplantation (LT) is the main treatment for paediatric biliary atresia (BA) in Asia. During LT, a series of haemodynamic changes often occur during LT reperfusion, which called postreperfusion syndrome (PRS), and PRS related to prolonged postoperative hospital stay, delayed recovery graft function increased mortality. To reduce adverse reactions after living (LDLT), our study's objectives were ascertain incidence analyse possible risk factors PRS.With approval Ethics...
Hepatic ischemic reperfusion (HIR) is a common pathophysiological process in many surgical procedures such as liver transplantation (LT) and hepatectomy. And it also an important factor leading to perioperative distant organ damage. Children undergoing major surgery are more susceptible various processes, including HIR, since their brains still developing the physiological functions incomplete, which can lead brain damage postoperative cognitive impairment, thus seriously affecting long-term...
Poor neurodevelopmental outcomes after pediatric liver transplantation seriously affect the long-term quality of life recipients, in whom hepatic ischemia reperfusion (HIR) is considered to play a pivotal role. However, link between HIR and brain injury remains unclear. Because circulating exosomes are as key mediators information transmission over long distances, we aimed assess role HIR-induced hippocampal young rats.We administered extracted from sera model rats normal via tail vein....
Acute kidney injury (AKI) is the primary cause of morbidity and mortality after major abdominal surgery. However, little known about effect anesthetics on development AKI pediatric liver transplantation (LT). This study aimed to compare effects propofol sevoflurane postoperative LT surgery.A total 120 patients scheduled for were randomly assigned receive either continuous infusion or inhalation sevoflurane. Serum creatinine (Scr), inflammatory medium oxidative stress factors renal biomarkers...
It has been demonstrated that dexmedetomidine (Dex) can protect patients with acute kidney injury from experiencing further tissue damage, however its mechanism of action remains unclear. The present study investigated the immune modulatory functions Dex in rats (AKI) induced via injection lipopolysaccharide into tail vein. ELISA analysis showed reduced levels inflammatory cytokines AKI a dose dependent manner. Furthermore, regulatory effects on cytokine production disappeared when α-2...
Mitochondrial DNA depletion syndrome (MDS) is a kind of autosomal recessive genetic disorder associated with reduction in mitochondrial (mtDNA) copy number caused by mutations nuclear genes during nucleotide synthesis, which affects the energy production tissues and organs. Changes hemodynamics liver transplantation may lead to high energy-demanding organs being vulnerable. This report described intraoperative management child MDS. Ultimately, was discharged smoothly without any...
Chronic cerebral hypoxia often leads to brain damage and inflammation. Propofol is suggested have neuroprotective effects under anaesthesia.
Liver transplantation induces self-injury and affects remote organs, such as the lung, kidney, intestine. Postoperative intestinal dysfunction has been associated with prolonged hospitalization a patient's health quality of life. Electroacupuncture (EA) proven effective in multiple organ protection. However, potential mechanism underlying protective effects EA on injury after liver remains unclear. After establishing an autogenous orthotopic (AOLT) model, we studied pretreatment AOLT. We...
Pediatric living donor liver transplantation is associated with slight alteration in cardiac enzymes without ongoing acute injury, but available information about the significance of these changes limited. The aims this study were to analyze link between anomalies intraoperative serum troponin I (cTnI) and lung injury during first week after transplantation. In retrospective study, 123 children suffering from biliary atresia enrolled. Several perioperative variables, particularly cTnI before...