A5061977944- interferon and immune responses
- Berberine and alkaloids research
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Cannabis and Cannabinoid Research
- Organ Transplantation Techniques and Outcomes
- Cancer-related molecular mechanisms research
- Transplantation: Methods and Outcomes
- Cell death mechanisms and regulation
- S100 Proteins and Annexins
- Endoplasmic Reticulum Stress and Disease
- FOXO transcription factor regulation
- Lipid metabolism and biosynthesis
- RNA regulation and disease
- Circular RNAs in diseases
- Renal and related cancers
- Gut microbiota and health
- Phagocytosis and Immune Regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Neonatal Respiratory Health Research
- Moringa oleifera research and applications
- Immune Response and Inflammation
- Pediatric Hepatobiliary Diseases and Treatments
- Gout, Hyperuricemia, Uric Acid
- Liver Disease Diagnosis and Treatment
University of California, Los Angeles
2020-2024
Tianjin Medical University General Hospital
2012-2024
Tianjin Medical University
2017-2019
Foxo1 transcription factor is an evolutionarily conserved regulator of cell metabolism, oxidative stress, inflammation, and apoptosis. Activation Hedgehog/Gli signaling known to regulate growth, differentiation, immune function. However, the molecular mechanisms by which interactive networks restrain stress response necroptosis are still poorly understood. Here, we report that myeloid-specific knockout (Foxo1M-KO) mice were resistant stress-induced hepatocellular damage with reduced...
Background and Aims: The hallmark of NAFLD or hepatic steatosis is characterized by lipid droplet (LD) accumulation in hepatocytes. Autophagy may have profound effects on metabolism innate immune response. However, how activation regulate the autophagic degradation intracellular LDs remains elusive. Approach Results: A mouse model a high-fat diet–induced NASH was used myeloid-specific stimulator interferon genes (STING) knockout STING/yes-associated protein (YAP) double mice. Liver injury,...
The cluster of differentiation 47 (CD47)-signal regulatory protein alpha (SIRPα) signaling pathway plays important roles in immune homeostasis and tissue inflammatory response. Activation the Hedgehog/smoothened (SMO)/GLI family zinc finger 1 (Gli1) regulates cell growth, differentiation, function. However, it remains unknown whether how CD47-SIRPα interaction may regulate Hedgehog/SMO/Gli1 mesenchymal stem (MSC)-mediated regulation during sterile liver injury.In a mouse model...
The mechanism of nonalcoholic fatty liver susceptibility to ischemia/reperfusion (IR) injury has not been fully clarified. Caspase 6 is a critical regulator in innate immunity and host defense. We aimed characterize the specific role IR-induced inflammatory responses livers. Human samples were harvested from patients undergoing ischemia-related hepatectomy evaluate expression. mice model, we generated 6-knockout (Caspase 6KO) investigate cellular molecular mechanisms macrophage IR-stimulated...
This study evaluated the mitigating effects of dietary chlorogenic acid (CGA) on colon damage and bacterial profile in a mouse model dextran sulphate sodium (DSS)-induced colitis. C57BL/6J mice were randomly assigned to receive one following treatments: (i) basal diet; (ii) diet with 2% CGA; (iii) 2.5% DSS or (iv) CGA DSS. Following 2-week pre-treatment period, CGA-DSS groups received drinking water for 5 days, while other two sterile water. Compared alone, was found reduce disease activity...
IRW (Ile-Arg-Trp), a bioactive peptide isolated from egg ovotransferrin, has been shown to exert anti-inflammatory effects. In this study, the effects of on inflammatory cytokines and microbiota were explored in human umbilical vein endothelial cells (HUVECs) lipopolysaccharide (LPS)-induced rat model peritonitis. Rats injected intraperitoneally with LPS establish HUVECs exposed for 12 h before introducing LPS. Notably, exerted beneficial against LPS-induced peritonitis, specifically, by...
Abstract Innate immune activation is critical for initiating hepatic inflammation during nonalcoholic steatohepatitis (NASH) progression. However, the mechanisms by which immunoregulatory molecules recognize lipogenic, fibrotic, and inflammatory signals remain unclear. Here, we show that high-fat diet (HFD)-induced oxidative stress activates Foxo1, YAP, Notch1 signaling in macrophages. Macrophage Foxo1 deficiency (Foxo1 M-KO ) ameliorated inflammation, steatosis, fibrosis, with reduced...
Dishevelled 2 (Dvl2) is a key mediator of the Wingless/Wnt signaling pathway that regulates cell proliferation, migration, and immune function. However, little known about role macrophage Dvl2 in modulating NOD1-mediated pyroptosis hepatocyte death oxidative stress-induced inflammatory liver injury. In mouse model inflammation, mice with myeloid-specific knockout (Dvl2
Caspase 6 is an essential regulator in innate immunity, inflammasome activation and host defense. We aimed to characterize the causal mechanism of liver sterile inflammatory injury.Human tissues were harvested from patients undergoing ischemia-related hepatectomy evaluate expression. Subsequently, we created 6-knockout (Caspase 6KO) mice analyze roles molecular mechanisms macrophage murine models ischemia/reperfusion (IR) injury.In human biopsies, expression was positively correlated with...
Steatotic livers are more susceptible to ischemia/reperfusion injury, and increase the risk of primary graft non-function after liver transplantation. The protective effects berberine have been described in various pathological models. However, it is unknown if exerts its beneficial action steatotic donors undergoing In present study, male Wistar rats were fed with high-fat diet (HFD) for 12 weeks induce moderate liver. Then orthotropic transplantation was constructed. Berberine (200...
Abstract Liver ischemia reperfusion (IR) injury significantly impacts clinical outcomes by increasing the risk of hepatic dysfunction after liver surgery. Fatty livers are more susceptible to IR stress. Recent studies have demonstrated that S100A9 plays a crucial role in both and progression steatosis. Nevertheless, precise mechanisms underlying these effects remain unclear. In our study, transcriptome analysis fatty subjected insult mice identified as an important mediator. Employing...
Abstract Background Gutless adenovirus (helper‐dependent adenoviral vector; HDAd) and lentiviral vectors (LV) are attractive for the gene therapy of muscle diseases. Because organization their DNA (episomal versus integrated) differs, we investigated whether strength specificity ΔUSEx3, a novel muscle‐specific promoter previously tested with plasmid, were maintained in context these vectors. Methods Two HDAds expressing β‐galactosidase regulated by ΔUSEx3 or CAG [cytomegalovirus (CMV)...
Pediatric living donor liver transplantation is associated with slight alteration in cardiac enzymes without ongoing acute injury, but available information about the significance of these changes limited. The aims this study were to analyze link between anomalies intraoperative serum troponin I (cTnI) and lung injury during first week after transplantation. In retrospective study, 123 children suffering from biliary atresia enrolled. Several perioperative variables, particularly cTnI before...
Background: lNUAK1 is strongly associated with organ fibrosis, but its causal mechanism for modulating lipid metabolism and hepatic inflammation underlying MASH has not been fully clarified. Method: In our study, human liver tissues from patients control subjects were obtained to evaluate NUAK1 expression. models established using C57BL/6 mice. Liver damage molecular mechanisms of the NUAK1-Caspase 6 signaling tested in vivo vitro. Results: clinical arm, expression was upregulated samples...
Objective To evaluate the role of silent information regulator factor 2-related enzyme 1(SIRT1)/Forkhead Box O3(FoxO3a)signaling pathway in berberine pretreatment-induced reduction hypoxia/reoxygenation(H/R)-caused injury to hepatic parenchymal cells. Methods Hepatic cells obtained from AML12 mice were cultured and seeded 6-well plates(2 ml/well)and 96-well plates(200 μl/well)at density 1×106 cells/ml.The divided into 4 groups(n=36 each)using a random number table: control group(group...
Objective To explore the risk factors of acute lung injury in pediatric living donor liver transplant recipients with biliary atresia (BA). Methods The clinical data were retrospectively reviewed for 112 BA children undergoing transplantation from May 2012 to March 2016.And after living-donor analyzed. Results Twenty-three (20.5%) developed transplantation.Univariate analysis showed that was associated age (P=0.010), pretransplant albumin (P=0.012), total bilirubin (P=0.001),...