A5101786530- Organ Transplantation Techniques and Outcomes
- Berberine and alkaloids research
- Anesthesia and Neurotoxicity Research
- Autophagy in Disease and Therapy
- Pain Mechanisms and Treatments
- Hydrogen's biological and therapeutic effects
- Neurological Disease Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Cardiac Ischemia and Reperfusion
- Organ Donation and Transplantation
- Anesthesia and Sedative Agents
- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- MicroRNA in disease regulation
- Intensive Care Unit Cognitive Disorders
- Stress Responses and Cortisol
- Reproductive Biology and Fertility
- Liver Disease and Transplantation
- Mitochondrial Function and Pathology
- Acupuncture Treatment Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Pain Management and Treatment
- Acute Kidney Injury Research
- Medical and Biological Ozone Research
- Traditional Chinese Medicine Analysis
Tianjin Medical University
2015-2025
Tianjin First Center Hospital
2015-2025
Henan Tianguan Group (China)
2025
Zhejiang University of Technology
2024
Changzhi Medical College
2024
Jiangnan University
2023
Health Foundation
2015
Development Fund
2015
Abstract Background Ischemia/reperfusion injury plays a crucial role in renal transplantation, and represents significant risk factor for acute failure delayed graft function. The pathophysiological contribution of endoplasmic reticulum mitochondria stress to ischemia/reperfusion has also been highlighted. Berberine (BBR) showed attenuate by inhibiting oxidative stress. study was carried out investigate whether the pretreatment BBR could reduce hypoxia/reoxygenation (H/R)-induced pathways....
// Jin-Dan He 1, * , Zhen Wang Shi-Peng Li 4, Yan-Jie Xu Yao Yu 1 Yi-Jie Ding Wen-Li 2 Rong-Xin Zhang 5 Hai-Ming 3 Hong-Yin Du 2, First Central Clinical College, Tianjin Medical University, 300192, P.R. China Department of Anesthesiology, Hospital, Liver Transplantation, Oriental Organ Transplant Center Key Laboratory Transplantation Tianjin, 4 General Surgery, The People's Hospital Jiaozuo City, 454002, Immunology and Inflammation, Immunology, Immune Microenvironment Diseases Educational...
In Brief Background Acute kidney injury (AKI) impacts the survival of liver transplant recipients severely. To date, related mechanism and effective therapy have not been rigorously explored. The present study aimed to explore role p53-mediated autophagy in protective effect hydrogen-rich saline (HRS) on AKI after orthotropic transplantation (OLT). Methods Adult male Sprague-Dawley rats were randomly allocated into four groups: sham, OLT, OLT with HRS (6 ml/kg) pretreatment (HS), chloroquine...
Background Our previous work demonstrated that persistent peripheral nociception (PPN) leads to synaptic plasticity and functional changes in the rat hippocampus. The protein kinase mTOR is a critical regulator of synthesis-dependent hippocampus as well associated with central pain sensitization. We examined role signaling pain-associated entorhinal cortex (EC) - hippocampal reveal possible cellular mechanisms underlying effects chronic on cognition emotion. Results Subcutaneous injection...
<h2>ABSTRACT</h2> Accurate identification of cows' likelihood conception during the period from recent calving to first artificial insemination (AI) will provide assistance in managing fertility dairy cows and contribute economic prosperity sustainability farm. The purpose this study was use FTIR spectroscopy collected predict cow's AI, or second AI. This specifically focused on role spectral farm data at different time windows improving accuracy model for predicting From 2019 2023,...
Background: As a heterogeneous clinical syndrome, acute respiratory distress syndrome (ARDS) is caused by infection-associated inflammation with limited treatment options. Esketamine possesses antiinflammatory properties, and it effective in treating lung diseases. Objective: This study aimed to unveil the efficacy mechanism of esketamine ARDS. Methods: Lipopolysaccharide (LPS) widely used induce inflammatory response injury. The mice model ARDS this was established through inhalation LPS....
Oxidative stress and excessive nitric oxide (NO) production play considerable roles in infarction-induced injury impairing cardiac functions. Crocin is the active constituent of Crocus sativus (saffron) with antioxidant properties has protective effects against disturbances induced by ischemia many organs. The present study aimed to investigate underlying mechanisms crocin on myocardial infarction (MI)-induced rats vivo. MI were intraperitoneally injected at different doses for seven...
Abstract Increasing evidence has linked autophagy to a detrimental role in hepatic ischemia- reperfusion (IR) injury (IRI). Here we focus on the of interferon regulatory factor-1 (IRF-1) regulating aggravate IRI. We found that IRF-1 was up-regulated during IRI and associated with an activation autophagic signaling. This increased expression, which allied high activity, amplified liver damage IR, effect abrogated by depletion. Moreover, contributed P38 induced apoptotic cell death, can play...
Abstract Liver ischemia reperfusion (IR) injury significantly impacts clinical outcomes by increasing the risk of hepatic dysfunction after liver surgery. Fatty livers are more susceptible to IR stress. Recent studies have demonstrated that S100A9 plays a crucial role in both and progression steatosis. Nevertheless, precise mechanisms underlying these effects remain unclear. In our study, transcriptome analysis fatty subjected insult mice identified as an important mediator. Employing...
Anesthesia neurotoxicity in developing brain has gained increasing attention. However, knowledge regarding its mitigating strategies remains scant. Sevoflurane, a commonly used anesthetic, is responsible for learning and memory deficits neonates. Molecular hydrogen reported to be potential neuroprotective agent because of antioxidative anti-inflammatory activities. This study aimed investigate the effect gas on sevoflurane neurotoxicity. The newborn rats were treated with and/or 2 h. Spatial...
Acute kidney injury (AKI) is the primary cause of morbidity and mortality after major abdominal surgery. However, little known about effect anesthetics on development AKI pediatric liver transplantation (LT). This study aimed to compare effects propofol sevoflurane postoperative LT surgery.A total 120 patients scheduled for were randomly assigned receive either continuous infusion or inhalation sevoflurane. Serum creatinine (Scr), inflammatory medium oxidative stress factors renal biomarkers...
Steatotic livers are more susceptible to ischemia/reperfusion injury, and increase the risk of primary graft non-function after liver transplantation. The protective effects berberine have been described in various pathological models. However, it is unknown if exerts its beneficial action steatotic donors undergoing In present study, male Wistar rats were fed with high-fat diet (HFD) for 12 weeks induce moderate liver. Then orthotropic transplantation was constructed. Berberine (200...
Wearable electronics for long-term monitoring of physiological signals should be capable removing sweat generated during daily motion, which significantly impacts signal stability, human comfort, and safety the electronics. In this study, we developed a double-layer polyurethane (PU) membrane with sweat-directional transport ability that can applied strain signals. The PU was composed hydrophilic, conductive layer relatively hydrophobic layer. composite exhibited varied pore size opposite...
Abstract Introduction Cordycepin has been reported to exhibit hepatic protective and anti‐inflammatory properties. Here, we investigated the role of cordycepin in ischemia/reperfusion (IR)‐induced liver injury a mouse model. Methods Mice were pretreated with by gavage for 3 weeks, followed establishment IR modeling. Liver injury, Suzuki's histological grading, apoptosis, inflammatory responses evaluated biochemical pathological analysis. Results It was found that pretreatment at 50 mg/kg...
Oocyte maturation is a critical step in the completion of female gametogenesis ovary; thus, for subsequent fertilization and embryogenesis. Vitrification embryo also has been shown to be closely associated with oocyte maturation. To improve quality developmental potential bovine oocytes derived from vitro (IVM), Pre-IVM C-type natriuretic peptide (CNP), melatonin (MT) combination, IGF1, FGF2, LIF (FLI) were supplemented IVM medium. In this current study, we cultured CNP 6 h before...