A5034436735- interferon and immune responses
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Organ Transplantation Techniques and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Genomics, phytochemicals, and oxidative stress
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Phytoplasmas and Hemiptera pathogens
- FOXO transcription factor regulation
- Adenosine and Purinergic Signaling
- Asthma and respiratory diseases
- Pulmonary Hypertension Research and Treatments
- Diet, Metabolism, and Disease
- CAR-T cell therapy research
- Renal and related cancers
- Cardiovascular Health and Risk Factors
- Mangiferin and Mango Extracts
- Respiratory Support and Mechanisms
- RNA regulation and disease
- Cell death mechanisms and regulation
- Drug-Induced Hepatotoxicity and Protection
Shanghai University of Sport
2024-2025
Yangzhou University
2025
University of California, Los Angeles
2020-2024
Hebei Agricultural University
2024
University Hospital Heidelberg
2023
Heidelberg University
2023
Nanjing Medical University
2019-2022
Jiangsu Province Hospital
2020-2022
Xuzhou Medical College
2017-2022
Jiangsu Cancer Hospital
2021
Regulatory T cells (Tregs) are crucial mediators of immune control. The characteristic gene expression and suppressive functions Tregs depend considerably on the stable activity transcription factor FOXP3. Transcriptional regulation Foxp3 has been studied in depth, but both function this also modulated at protein level. However, molecular players involved posttranslational FOXP3 just beginning to be elucidated. Here, we found that TRAF6-deficient were dysfunctional vivo; mice with...
Foxo1 transcription factor is an evolutionarily conserved regulator of cell metabolism, oxidative stress, inflammation, and apoptosis. Activation Hedgehog/Gli signaling known to regulate growth, differentiation, immune function. However, the molecular mechanisms by which interactive networks restrain stress response necroptosis are still poorly understood. Here, we report that myeloid-specific knockout (Foxo1M-KO) mice were resistant stress-induced hepatocellular damage with reduced...
The cluster of differentiation 47 (CD47)-signal regulatory protein alpha (SIRPα) signaling pathway plays important roles in immune homeostasis and tissue inflammatory response. Activation the Hedgehog/smoothened (SMO)/GLI family zinc finger 1 (Gli1) regulates cell growth, differentiation, function. However, it remains unknown whether how CD47-SIRPα interaction may regulate Hedgehog/SMO/Gli1 mesenchymal stem (MSC)-mediated regulation during sterile liver injury.In a mouse model...
Cancer-associated fibroblasts (CAFs) are a major component of hepatocellular carcinoma (HCC) stroma that critically involved in HCC cancer chemoresistance, but the mechanism has not been elucidated. Previous studies have reported CD73 exerted an immunosuppressive function cancer. Here, we explored by which CAFs regulates CD73+ cells and clarified whether promote chemoresistance cells.We used co-culture method to study relationship between cells. Immunohistochemistry was applied evaluate...
Nuclear-erythroid-2-related factor 2 (Nrf2) is involved in the pathogenesis of different liver diseases. Herein, we first demonstrated that Nrf2 expression was diminished nonalcoholic steatohepatitis (NASH) macrophages. In myeloid Nrf2-deficiency mice, aggravated steatosis and inflammation high-fat-diet (HFD)-fed mice were observed compared with chow-diet group. Moreover, increasing inflammatory cytokines influenced lipid metabolism hepatocytes vivo vitro. Further study showed regulated...
ABSTRACT Figs, known for their high‐antioxidant capacity, have shown potential in regulating obesity. However, research on fig‐based products and the mechanisms behind effects remains limited. This study aims to systematically evaluate of fig meal replacement powder (FMRP) obesity mitigating obesity‐induced oxidative stress through both vitro vivo experiments, while also elucidating its underlying mechanisms. The results demonstrated that FMRP exhibited superior nutritional value antioxidant...
Abstract Innate immune activation is critical for initiating hepatic inflammation during nonalcoholic steatohepatitis (NASH) progression. However, the mechanisms by which immunoregulatory molecules recognize lipogenic, fibrotic, and inflammatory signals remain unclear. Here, we show that high-fat diet (HFD)-induced oxidative stress activates Foxo1, YAP, Notch1 signaling in macrophages. Macrophage Foxo1 deficiency (Foxo1 M-KO ) ameliorated inflammation, steatosis, fibrosis, with reduced...
Dishevelled 2 (Dvl2) is a key mediator of the Wingless/Wnt signaling pathway that regulates cell proliferation, migration, and immune function. However, little known about role macrophage Dvl2 in modulating NOD1-mediated pyroptosis hepatocyte death oxidative stress-induced inflammatory liver injury. In mouse model inflammation, mice with myeloid-specific knockout (Dvl2
Abstract Background Notch signaling is highly conserved and critically involved in cell differentiation, immunity, survival. Activation of the pathway modulates immune functions during inflammatory response. However, it remains unknown whether how macrophage Notch1 may control innate TAK1, RIPK3-mediated hepatocyte necroptosis liver ischemia reperfusion injury (IRI). This study investigated molecular mechanisms modulating TAK1-mediated responses RIPK3 IRI. Methods Myeloid-specific knockout...
Objective: To investigate the association between types of obesity and 10-year-coronary heart disease risk in Tibet Xinjiang China. Methods: Using multi-stage random sampling method, 7 631 participants aged 35 or older were examined under International Standardized Examination process but with only 5 802 eligible for analysis, 2015-2016 season. Results: The prevalence rates general obesity, central visceral compound 0.53%, 12.62%, 10.08% 42.35%, respectively. Out all cases, 58.65% (1 441/2...
Abstract Background: Notch signaling is highly conserved and critically involved in cell differentiation, immunity, survival. Activation of the pathway modulates immune functions during inflammatory response. However, it remains unknown whether how macrophage Notch1 may control innate TAK1, RIPK3-mediated hepatocyte necroptosis liver ischemia reperfusion injury (IRI). This study investigated molecular mechanisms modulating TAK1-mediated responses RIPK3 IRI. Methods: Myeloid-specific knockout...
Objective: To optimize the stimulation and activation system of mouse CD3(+) T cells in vitro explore optimal infection time to establish CD19 chimeric antigen receptor (mCD19 CAR-T) , also verify its killing effect vivo vitro. Method: Splenic CD3(+)T were isolated purified using magnetic beads, cultured Soluble anti-CD3/CD28, PMA+Ionomycin, Plated anti-CD3/CD28. Cell apoptosis assessed by flow cytometry after 8, 24, 48, 72 hours. ScFv plasmid antibody was transfected plat-E package...