A5080628640- Melanoma and MAPK Pathways
- PARP inhibition in cancer therapy
- Antimicrobial Peptides and Activities
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- Immune Response and Inflammation
- Dermatology and Skin Diseases
- Cell Adhesion Molecules Research
- Biochemical and Structural Characterization
- DNA Repair Mechanisms
- T-cell and B-cell Immunology
- Advanced Breast Cancer Therapies
- CAR-T cell therapy research
- Enzyme Production and Characterization
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Antimicrobial Resistance in Staphylococcus
- PI3K/AKT/mTOR signaling in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Heat shock proteins research
- Pediatric health and respiratory diseases
- Immune Cell Function and Interaction
- melanin and skin pigmentation
- Cancer Cells and Metastasis
- Cancer Research and Treatments
University Children's Hospital Tübingen
2022-2025
University of Tübingen
2015-2024
Hautklinik Heidelberg
2001-2010
University of Turin
2009
National Institute of Allergy and Infectious Diseases
2009
National Institutes of Health
2009
Berlin-Brandenburger Centrum für Regenerative Therapien
2009
Cleveland Clinic Lerner College of Medicine
2009
University of Stuttgart
2007
Ludwig-Maximilians-Universität München
2001
It is known that two-thirds of patients who develop clinical metastases following treatment a primary cutaneous melanoma initially present with locoregional and one-third distant metastases. However, few reports in the literature give detailed figures on different metastatic pathways melanoma.The aim study was to perform analysis pathways, time course development factors influencing them.In series 3001 at first presentation, 466 subsequently developed metastasis were followed-up over long...
To prospectively examine and evaluate the results of follow-up procedures in a large cohort cutaneous melanoma patients.This was prospective study 2,008 consecutive patients with stage I to IV from 1996 1998 on yield stage-appropriate examinations according German guidelines. Documentation patient data comprised demography, primary tumor specifics, any clinical technical performed. The detection metastasis classified as early or late, means their resulting overall survival probabilities were...
Abstract Antimicrobial peptides are an integral part of the epithelial innate defense system. Dermcidin (DCD) is a recently discovered antimicrobial peptide with broad spectrum activity. It constitutively expressed in human eccrine sweat glands and secreted into sweat. Patients atopic dermatitis (AD) have recurrent bacterial or viral skin infections pronounced colonization Staphylococcus aureus. We hypothesized that patients AD reduced amount DCD contributing to compromised constitutive...
Human gammadelta T cells expressing a V gamma 9V delta 2 T-cell receptor (TCR) kill various tumour including autologous tumours. In addition to TCR-dependent recognition, activation of NKG2D-positive by cell-expressed NKG2D ligands can also trigger cytotoxic effector function. this study, we investigated the involvement TCR versus in cell recognition as prerequisite identify types suitable for T-cell-based immunotherapy. We have characterized epithelial different origin with respect surface...
Drug resistance in melanomas may be overcome by therapies that trigger endoplasmic reticulum stress.
Recently our groups discovered lugdunin, a new cyclic peptide antibiotic that inhibits Staphylococcus aureus epithelial colonization in humans and rodents. In this work, we analyzed its immuno-modulatory antimicrobial potential as single agent or combination with other microbiota- host-derived factors. We show pretreatment of primary human keratinocytes mouse skin lugdunin microbiota-derived factors results significant reduction S. colonization. Moreover, increases expression release LL-37...
Antimicrobial peptides (AMPs) are important effector molecules of innate immunity, protecting epithelial surfaces multicellular organisms. In human skin two classes AMPs-the beta-defensins and the cathelicidins-are produced by keratinocytes primarily under inflammatory conditions. contrast, dermcidin (DCD), a recently discovered AMP with broad-spectrum activity, is expressed in eccrine sweat glands transported via to epidermal surface.To investigate whether DCD expression induced conditions...
In melanoma, several signalling pathways are constitutively activated. Among them, the RAS/RAF/MEK/ERK (MAPK) and PI3K/AKT (AKT) activated through multiple mechanisms appear to play a major role in melanoma development progression.In this study, we examined whether targeting MAPK and/or AKT would have therapeutic effects against melanoma.Using panel of pharmacological inhibitors (BAY 43-9006, PD98059, U0126, wortmannin, LY294002) inhibited at different levels evaluated on growth, survival...
Dermcidin (DCD) is a recently described antimicrobial peptide, which constitutively expressed in eccrine sweat glands and transported via to the epidermal surface. By postsecretory proteolytic processing dermcidin protein gives rise several truncated DCD peptides differ length net charge. In order understand mechanism of activity, we analyzed spectrum activity naturally processed dermcidin-derived peptides, secondary structure different solvents, ability these interact with or permeabilize...
Beta-catenin plays an important role in embryogenesis and carcinogenesis by controlling either cadherin-mediated cell adhesion or transcriptional activation of target gene expression. In many types cancers nuclear translocation beta-catenin has been observed. Our data indicate that during melanoma progression increased dependency on the function takes place. Blockade metastatic lines efficiently induces apoptosis, inhibits proliferation, migration invasion monolayer 3-dimensional skin...
In previous studies we identified the transcription/translation factor Y-box-binding protein (YB-1) as a gene that is upregulated in primary melanoma and metastases when compared to benign melanocytic nevi. To analyze whether YB-1 expression correlates with progression vitro vivo, performed analysis on cell lines representing different stages of tissues nevi, metastases. Our data indicate melanocytes increased cells vivo translocated into nucleus invasive metastatic cells. reveal functional...