A5075723800- Pancreatic function and diabetes
- Diabetes Management and Research
- Pluripotent Stem Cells Research
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Liver physiology and pathology
- Gene Regulatory Network Analysis
- CRISPR and Genetic Engineering
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
Peking University
2019-2024
Center for Life Sciences
2019-2024
Keep hepatocytes fresh Freshly isolated primary human (PHHs) quickly lose their identity and function in vitro, limiting application modeling infectious liver diseases screening drugs. Xiang et al. describe a simple effective five-chemical culture condition that can maintain the mature of cultured PHHs for an extended period time. this way support entire viral life cycle recapitulate long-term infection hepatitis B virus. This system created useful drug-screening platform developing new...
Cellular conversion can be induced by perturbing a handful of key transcription factors (TFs). Replacement direct manipulation TFs with chemical compounds offers less laborious and safer strategy to drive cellular for regenerative medicine. Nevertheless, identifying optimal currently requires large-scale screening libraries, which is resource intensive. Existing computational methods aim at predicting cell TFs, but there are no targeting these TFs. Here, we develop single cell-based platform...