A5101809660- Pancreatic function and diabetes
- Diabetes and associated disorders
- Natural Language Processing Techniques
- Diabetes Management and Research
- Cannabis and Cannabinoid Research
- Diabetes Treatment and Management
- Retinal Imaging and Analysis
- Genetics and Neurodevelopmental Disorders
- Physiological and biochemical adaptations
- Veterinary medicine and infectious diseases
- Advanced Computational Techniques and Applications
- Gastric Cancer Management and Outcomes
- Potassium and Related Disorders
- Topic Modeling
- Cell Adhesion Molecules Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Virology and Viral Diseases
- Adipose Tissue and Metabolism
- Viral Infections and Vectors
- Advanced Graph Neural Networks
- FOXO transcription factor regulation
- Metabolism, Diabetes, and Cancer
- Medical Research and Treatments
- Medical Image Segmentation Techniques
- Mosquito-borne diseases and control
Tianjin First Center Hospital
2022-2024
Tianjin Medical University
2022-2024
Nankai University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
National Natural Science Foundation of China
2023
Creative Commons
2023
Committee on Publication Ethics
2023
University of Manchester
2021
Hubei Academy of Agricultural Sciences
2019
The FK506-binding protein 51 (FKBP51, encoded by FKBP5 gene) has emerged as a critical regulator of mammalian endocrine stress responses and potential pharmacological target for metabolic disorders, including type 2 diabetes (T2D). However, in β cells, which secrete the only glucose-lowering hormone-insulin, expression function not been documented. Here, using human pancreatic tissue primary islets, we demonstrated abundant displayed an responsive induction upon acute inflammatory mimicked...
Background. Islet transplantation is a promising therapy for patients with type 1 diabetes. However, ischemic injury to the donor islets during cold preservation leads reduced islet quality and compromises transplant outcome. Several studies imply that liraglutide, glucagon-like peptide-1 receptor agonist, has positive effect on promoting survival, but its impact cold-ischemic remains unexplored. Therefore, aim of this study was investigate whether liraglutide can improve efficacy by...
Type 2 diabetes mellitus (T2D) affects 463 million individuals worldwide. β-cell dysfunction and relatively inadequate mass has been implicated in the pathogenesis of T2D. Primary human islets from T2D patients can reveal islet underlying mechanisms thus have become valued resources for research. Our center (Human Islet Resource Center, China) prepared a number batches organ donors. The present study aims to characterize isolation processes, yields, qualities pancreases by comparing with...
Large Language Models (LLMs) have demonstrated remarkable performance across various natural language processing tasks. Recently, several LLMs-based pipelines been developed to enhance learning on graphs with text attributes, showcasing promising performance. However, are well-known be susceptible adversarial attacks and it remains unclear whether LLMs exhibit robustness in graphs. To address this gap, our work aims explore the potential of context Specifically, we investigate against graph...
Islet transplantation is a promising therapy for diabetes, yet the limited survival and functionality of transplanted islet grafts hinder optimal outcomes. Glucagon-like peptide-1 (GLP-1), an endogenous hormone, has shown potential to enhance function; however, its systemic administration can result in poor localization undesirable side effects. To address these challenges, we developed novel peptide-based nanofiber hydrogel incorporating GLP-1 localized delivery. By conjugating FFG...
Compared with patients who undergo renal and islet transplantation sequentially, simultaneous omentum intraomental bio-scaffold islet-kidney in type 1 diabetes complicated by failure has the advantages of donor homologation, less trauma, lower cost, easier acceptance patients. Omentum been gradually applied clinical practice, rare complications have reported. Here we report a case abdominal abscess associated extended-spectrum β-lactamase patient underwent transplantation; grafts remained...