A5064071302- Cancer-related molecular mechanisms research
- Flavonoids in Medical Research
- Liver physiology and pathology
- Antimicrobial Peptides and Activities
- Protein Hydrolysis and Bioactive Peptides
- Immune cells in cancer
- MicroRNA in disease regulation
- Cardiac Ischemia and Reperfusion
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Phagocytosis and Immune Regulation
- Pancreatic function and diabetes
- Cancer, Lipids, and Metabolism
- Marine Sponges and Natural Products
- Pluripotent Stem Cells Research
- Bone and Dental Protein Studies
- Cytokine Signaling Pathways and Interactions
- Traditional Chinese Medicine Analysis
- Ferroptosis and cancer prognosis
- Ginseng Biological Effects and Applications
- Lipid metabolism and disorders
- Enzyme Production and Characterization
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
Liaoning University of Traditional Chinese Medicine
2019-2024
China National Building Materials Group (China)
2022
Peking University
2014-2019
Center for Life Sciences
2014-2019
Hunan Agricultural University
2014-2019
Keep hepatocytes fresh Freshly isolated primary human (PHHs) quickly lose their identity and function in vitro, limiting application modeling infectious liver diseases screening drugs. Xiang et al. describe a simple effective five-chemical culture condition that can maintain the mature of cultured PHHs for an extended period time. this way support entire viral life cycle recapitulate long-term infection hepatitis B virus. This system created useful drug-screening platform developing new...
Signal regulatory protein alpha (SIRPa) is an essential signalling molecule that modulates inflammatory responses in macrophages. However, the regulation of SIRPs and its dynamic changes macrophages under stimulation atherosclerosis remain uncertain.The study aimed to identify miRNAs regulate SIRPa transcription their roles modulating phagocytosis, differentiation cholesterol efflux macrophages.ApoE knockout mice were fed with a high-fat diet for 12 weeks. Intimal lesion areas lipid...
Purpose: Atherosclerosis is the most common and significant form of arterial disease, characterized primarily by lipid accumulation inflammatory cell infiltration as its main pathological basis. This study aims to investigate molecular mechanisms associated pathways which iron may be involved in metabolism abnormalities atherosclerotic mice. Methods: Relying on ApoE-/- mouse body position observation, blood biochemical analysis, oxidative stress test aortic tissue sectioning techniques,...
Abstract SM03, an anti-CD22 recombinant IgG1 mAb, is currently in a phase III clinical trial for the treatment of rheumatoid arthritis (NCT04312815). SM03 showed good safety and efficacy I systemic lupus erythematosus II moderate to severe trials. We propose success as therapeutic autoimmune diseases through utilization novel mechanism action unique SM03. CD22, inhibitory coreceptor BCR, potential immunotherapeutic target against diseases. could disturb CD22 homomultimeric configuration...
Autoimmune diseases (AD) account for a high percentage of the population. One most prevalent is autoimmune thyroiditis (AIT). However, therapeutic effects Buzhong Yiqi (BZYQ) decoction on AIT have not been studied yet. The majority present study was conducted NOD.H-2
Autoimmune thyroiditis (AIT) is the most common autoimmune thyroid disease. In recent decades, its incidence and prevalence have sharply increased. Yiqi Huatan Huoxue recipe a traditional Chinese medicine formula we use to treat AIT. Its clinical efficacy clear, but specific mechanism remains unclear. This study aims explore whether pyroptosis mediated by SIRT1/NF-κB/NLRP3 signaling pathway one of therapeutic mechanisms recipe.
Abstract Background: Acute myocardial injury (AMI), which is induced by renal ischemia-reperfusion (IR), a significant cause of acute kidney (AKI)-related associated death. Obesity increases the severity and frequency AMI AKI. Tanshinone IIA (TIIA) combined with cyclosporine A (CsA) pretreatment was used to alleviate cell apoptosis IR, determine whether TIIA CsA would attenuate modulating mitochondrial function through PI3K/Akt/Bad pathway in obese rats. Methods: Male rates were fed high fat...