A5101808038- Autopsy Techniques and Outcomes
- Spectroscopy Techniques in Biomedical and Chemical Research
- Automotive and Human Injury Biomechanics
- Injury Epidemiology and Prevention
- Mesenchymal stem cell research
- Traffic and Road Safety
- Traumatic Ocular and Foreign Body Injuries
- Traumatic Brain Injury and Neurovascular Disturbances
- Bone fractures and treatments
- Restraint-Related Deaths
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Medical Imaging and Analysis
- Forensic Entomology and Diptera Studies
- Healthcare cost, quality, practices
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Monoclonal and Polyclonal Antibodies Research
- Thermal Regulation in Medicine
- Circular RNAs in diseases
- Metabolomics and Mass Spectrometry Studies
- Infrared Thermography in Medicine
- Trauma Management and Diagnosis
- MicroRNA in disease regulation
- S100 Proteins and Annexins
Institute of Forensic Science
2015-2024
Tianjin University
2024
Tongji University
2013-2023
Beijing University of Posts and Telecommunications
2023
Medical Architecture (United Kingdom)
2023
China National Building Materials Group (China)
2016-2022
Weatherford College
2021-2022
Fudan University
2004-2022
Shanghai First Maternity and Infant Hospital
2013-2022
Creative Commons
2022
The goal of this study was to provide evidence that melatonin improves muscle healing following blunt skeletal injury. For purpose, we used 56 rats and induced an open After injury, all animals received either daily or vehicle solution intraperitoneally. Subsequent observations were performed at day 1, 4, 7, 14 after assessment fast twitch tetanic force, analyzed leukocyte infiltration, satellite cell number, apoptosis. We further quantified the expression receptor activation...
BackgroundThe EXTREME regimen (chemotherapy [CT; cisplatin/carboplatin and 5-fluorouracil]) plus cetuximab is a standard-of-care first-line (1L) treatment for patients with recurrent and/or metastatic squamous cell carcinoma of the head neck (R/M SCCHN), as supported by international guidelines. The phase III CHANGE-2 trial assessed efficacy safety modified CT (with reduced dose both components) versus 1L Chinese R/M SCCHN.MethodsPatients were randomised to receive up six cycles followed...
Abdominal trauma accounts for nearly 20% of all severe traffic injuries and can often result from intentional physical violence, which blunt liver injury is regarded as the most common associated with a high mortality rate. Liver may be caused by direct impact certain velocity energy on abdomen, in lacerated penetration fractured ribs. However, ruptures without rib cage fractures were found autopsies series cases. All victims sustained punches abdomen fist. Many studies have been dedicated...
BACKGROUND:Increased lipid accumulation in renal tubular epithelial cells (TECs) contributes to their injury and dysfunction progression of tubulointerstitial fibrosis. Berberine (BBR), a natural plant alkaloid isolated from traditional medicine herbs, is effective lowing serum lipid, has protective effect on chronic kidney disease (CKD) with dyslipidemia, including diabetic nephropathy. The aim this study was investigate the BBR palmitate (PA)-induced apoptosis TECs. MATERIAL AND...
Diabetic nephropathy (DN), a frequent diabetes complication, has complex pathogenesis. Circular RNAs (circRNAs) circ_0000712 been reported to be upregulated in kidney tissues and high glucose (HG)-inducted Mesangial cells (MCs). This study is designed explore the role mechanism of HG-inducted MCs injury DN. Circ_0000712, microRNA-879-5p (miR-879-5p), SRY-Box Transcription Factor 6 (SOX6) levels were detected by real-time quantitative polymerase chain reaction (RT-qPCR). Cell apoptosis was...
Constitutive activation of the Hedgehog (Hh) signaling pathway has been implicated in development many human malignancies. Hh targets, such as Patched (PTCH), smoothened (SMO), Sonic hedgehog (SHH) and glioma-associated oncogene homologue 1 (GLI1), are markers expressed most Hh-associated tumors. The protein kinase LKB1 shown to slow proliferation induce cell-cycle arrest cell lines. In this study, we observed that activated decreased expression factors related reporter activity MDA-MB-231...
The toughest challenge in pedestrian traffic accident identification lies ascertaining injury manners. This study aimed to systematically simulate and parameterize 3 types of craniocerebral including impact injury, fall run-over compare the response outcomes different
Estimation of the postmortem interval (PMI) is a complicated task in forensic medicine, especially during homicide and unwitnessed death investigations. Many biological, chemical, physical indicators can be used to determine interval, but most are not accurate. Here, we present novel matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) method that for estimation PMI using molecular images multivariate analyses. In this study, demonstrate both rat human...
Mesenchymal stem cells (MSCs) are multipotent that can differentiate into a variety of cell types.Therefore, they widely explored in regenerative medicine.The interaction MSCs with biomaterials is great importance for proliferation, differentiation and function, be strongly influenced by numerous factors, such as the chemical nature mechanical properties material surface.In this study, we investigated bone marrow derived human different amorphous transparent polymers namely polystyrene (PS),...
Although muscle regeneration after injury is accompanied by apoptotic cell death, prolonged apoptosis inhibits restoration. The goal of our study was to provide evidence that inhibition improves function following blunt skeletal injury. Therefore, 24 rats were used for induction the left soleus using an instrumented clamp. All animals received either 3.3 mg/kg i.p. pan-caspase inhibitor Z-valinyl-alanyl-DL: -aspartyl-fluoromethylketone (z-VAD.fmk) (n = 12 animals) or equivalent volumes...
Abstract SM03, an anti-CD22 recombinant IgG1 mAb, is currently in a phase III clinical trial for the treatment of rheumatoid arthritis (NCT04312815). SM03 showed good safety and efficacy I systemic lupus erythematosus II moderate to severe trials. We propose success as therapeutic autoimmune diseases through utilization novel mechanism action unique SM03. CD22, inhibitory coreceptor BCR, potential immunotherapeutic target against diseases. could disturb CD22 homomultimeric configuration...
The aim of this study was to identify the influence specimen geometry and size on results aortic uniaxial tensile tests using custom-designed tissue cutters, clamps molds. Six descending thoracic aortas from pigs were used for rectangular sample tests, in which circumferential axial specimens had widths 6 mm, 8 mm 10 mm. other six dog-bone-shaped punched into circumferential, oblique with 2 4 We performed compared test results. showed that mid-sample failure occurred 85.2% 11.1% samples,...
Anaphylaxis is a rare but well-known cause of sudden unexpected death, although data from forensic autopsies in anaphylactic deaths are limited. Herein, retrospective study series allergic 2009 through 2019 Shanghai, China, was conducted to investigate the demographic, medical, and pathological characteristics fatal anaphylaxis improve medicolegal understanding on death. Sixty-two autopsy cases death were registered this study. Males dominated (74.2%) against females (25.8%), with an average...