A5081954344- Dental materials and restorations
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Endodontics and Root Canal Treatments
- Dental Implant Techniques and Outcomes
- Organ Transplantation Techniques and Outcomes
- Dental Research and COVID-19
- Calcium Carbonate Crystallization and Inhibition
- Autophagy in Disease and Therapy
- Dental Radiography and Imaging
- Dental Erosion and Treatment
- Oral and Maxillofacial Pathology
- Cancer-related molecular mechanisms research
- Adenosine and Purinergic Signaling
- Heme Oxygenase-1 and Carbon Monoxide
- Diet, Metabolism, and Disease
- Cleft Lip and Palate Research
- dental development and anomalies
- Periodontal Regeneration and Treatments
- Regulation of Appetite and Obesity
- Graphene and Nanomaterials Applications
- Cancer-related gene regulation
- Laser Applications in Dentistry and Medicine
- Inflammatory mediators and NSAID effects
- Gastrointestinal motility and disorders
Shanghai Tenth People's Hospital
2015-2025
Tongji University
2015-2025
Gansu University of Traditional Chinese Medicine
2024
Nanjing Medical University
2019-2022
Tianjin Medical University
2017
Tianjin First Center Hospital
2017
Shanghai Second People's Hospital
2008
Matsumoto Dental University
2006-2007
As a new group of important effector molecules involved in multiple cancer types, including breast cancer, lung and oral squamous cell carcinoma, long noncoding RNAs (lncRNAs) have attracted considerable attention recently. However, the underlying cause that induces dysregulated lncRNAs remains poorly understood. In present study, regulatory model lncRNA placenta‑specific protein 2 (PLAC2) upregulation carcinoma (OSCC) was investigated its biological functions OSCC malignant progression...
Leonurine, a major bioactive component from Herba leonuri, has been shown to exhibit anti-inflammatory and antioxidant effects. The aim of this study was investigate the effect leonurine on bone marrow-derived mesenchymal stem cells (BMSCs) as therapeutic approach for treating osteoporosis.Rat (rBMSCs) were isolated 4-weeks-old Sprague-Dawley rats. cytocompatibility rBMSCs tested via CCK-8 assays flow cytometric analyses. effects rBMSC osteogenic differentiation analyzed ALP staining,...
Osteoporosis bears an imbalance between bone formation and resorption, which is strongly related to oxidative stress. The function of leonurine on marrow-derived mesenchymal stem cells (BMSCs) under stress still unclear. Therefore, this study was aimed at identifying the protective effect H2O2 stimulated rat BMSCs. We found that can alleviate cell apoptosis promote differentiation ability BMSCs induced by appropriate concentration 10 μM. Meanwhile, intracellular ROS level COX2 NOX4 mRNA...
The purpose of this study was to investigate how cyclic loading influenced the fracture toughness hot-press lithium disilicate and zirconia core materials whether there an increase in propensity for crown failure. Two types all-ceramic crowns including IPS e.max Press system (n=24) Lava (n=24), were selected. Sectioned specimens subjected with maximum magnitude 200 N (R=0.1) until two million cycles. material properties Young's modulus (E) hardness (H) (KIC) evaluated using indentation...
Following the publication of this paper, it was drawn to Editor's attention by a concerned reader that certain immunofluorescence assay data shown in Figs. 3C on p. 1189 and 4E 1190 were strikingly similar appearing different form another pair articles written authors at research institutes had already been published elsewhere prior submission paper <em>International Journal Oncology</em>. Given abovementioned apparently previously, Editor Oncology</em> has decided should be retracted from...
Abstract Hypodontia is caused by interactions among genetic, epigenetic and environmental factors during tooth development, but the actual mechanism unknown. DNA methylation now appears to play a significant role in abnormal developments, flawed phenotypes acquired diseases. Methylated immunoprecipitation (MeDIP) has been developed as new method of scanning large-scale DNA-methylation profiles within particular regions or entire genome. Here, we performed genome-wide scan paired samples...
Object: The aims of the study were to explore protective effects S-propargyl-cysteine (SPRC) on periodontitis and determine underlying mechanisms. Methods: A rat model was constructed by injecting LPS SPRC (0, 25, 50 mg/kg/d) administered intraperitoneally. H2S CSE level detected. alveolar bone evaluated micro-CT, HE staining methylene blue analysis. Inflammation-related factors, Treg Th17 cells detected immunohistochemistry, RT-PCR, immunofluorescence, Western blot flow cytometry....
This study aimed to assess generic health-related quality of life (HRQoL), pain intensity, and anxiety levels the relationship between three aspects in healthy young Chinese orthodontic patients early stage treatment. We enrolled 252 eligible participants (10–29 years old) complete validated versions questionnaires, including State-Trait Anxiety Inventory (S-AI), visual analogue scale (VAS), Short-Form 36-Item Health Survey (SF-36) at baseline on days 1, 2, 3, 7, 14, 30 after initial...
Autophagy is a critical lysosomal pathway that degrades cytoplasmic components to maintain cell homeostasis and provide substrates for energy metabolism. A study revealed heme oxygenase-1 (HO-1)-transduced bone marrow-derived mesenchymal stem cells (BM-MSCs) could protect 50% reduced-size liver transplantation (RSLT) in rat model. However, the mechanisms remain mostly unknown. The aim of present was explore effects related mechanism autophagy on protection conferred by HO-1-transduced...
The aim of this study is to investigate the biological activity and antibacterial property cerium oxide-incorporated calcium silicate coatings (CeO2-CS) in dental implants.In study, MC3T3-E1 cells cultured on plastic, Ti-6Al-4V, coating served as blank, control, CeO2-CS groups, respectively. A cell counting kit-8 (CCK-8) flow cytometry were used evaluate biocompatibility. osteoblastic differentiation was also analyzed by quantitative real-time polymerase chain reaction analysis. CCK-8 counts...
Recent studies have revealed that long non-coding RNAs (lncRNAs) involve in the progression of oral squamous cell carcinoma (OSCC). These lncRNAs emerged as biomarkers or therapeutic targets for OSCC. We here aimed to investigate role lncRNA LINC01315 OSCC and related mechanisms. DLG3 were determined be poorly expressed while microRNA-211 (miR-211) was highly tissues cells using RT-qPCR western blot analysis. Based on results obtained from dual-luciferase reporter gene, RIP, FISH assays,...
To investigate the effects of heme oxygenase-1 (HO-1)-modified bone marrow mesenchymal stem cells (BMMSCs) on microcirculation and energy metabolism hepatic sinusoids following reduced-size liver transplantation (RLT) in a rat model.BMMSCs were isolated cultured vitro using an adherent method, then transduced with HO-1-bearing recombinant adenovirus to construct HO-1/BMMSCs. A acute rejection model 50% RLT was established two-cuff technique. Recipients divided into three groups based...
Our research aimed to look into the clinical traits and genetic mutations in sporadic non-syndromic anodontia gain insight role of PAX9, MSX1, AXIN2 EDA phenotypes, especially for PAX9. Material Methods The female proband her family members from ethnic Han families underwent complete oral examinations received a retrospective review. Venous blood samples were obtained screen variants AXIN2, genes. A case-control study was performed on 50 subjects with tooth agenesis (cases) 100 healthy...