A5100326202- Probiotics and Fermented Foods
- Gut microbiota and health
- Biofuel production and bioconversion
- Inflammatory Bowel Disease
- Proteins in Food Systems
- Microbial Metabolic Engineering and Bioproduction
- Muscle metabolism and nutrition
- Cancer-related molecular mechanisms research
- Microencapsulation and Drying Processes
- Glycosylation and Glycoproteins Research
- Muscle Physiology and Disorders
- Meat and Animal Product Quality
- Advanced Sensor and Energy Harvesting Materials
- Microscopic Colitis
- Infant Nutrition and Health
- Carbohydrate Chemistry and Synthesis
- Genetics, Aging, and Longevity in Model Organisms
- Monoclonal and Polyclonal Antibodies Research
- Protein Hydrolysis and Bioactive Peptides
- Eosinophilic Esophagitis
- Genomics and Phylogenetic Studies
- Oral microbiology and periodontitis research
- Clostridium difficile and Clostridium perfringens research
- Peroxisome Proliferator-Activated Receptors
- Digestive system and related health
Tsinghua University
2020-2025
Inner Mongolia University
2023-2025
Tianjin Medical University General Hospital
2024
Northeast Agricultural University
2008-2024
Wuhan Sports University
2023-2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Sun Yat-sen University
2024
State Key Laboratory of Oncology in South China
2024
Sun Yat-sen University Cancer Center
2024
In this paper, conjugated four polyphenols (epigallocatechin gallate [EGCG], procyanidine [PA], apple polyphenol [AP], puerarin [PUE]) with whey protein isolate (WPI) was prepared under alkaline condition. The covalent interaction between and WPI confirmed by the determination of binding equivalent. Fluorescence spectroscopy fourier transform infrared spectra analysis were used to identify changes in structure. scanning electron microscopy data particle size distribution demonstrated surface...
Background: Glioblastoma (GBM) is the most prevalent malignant brain tumor, significantly impacting physical and mental wellbeing of patients. Several studies have demonstrated a close association between gut microbiota development GBM. In this investigation, Mendelian randomization (MR) was employed to rigorously evaluate potential causal relationship Methods: We utilized summary statistics derived from genome-wide (GWAS) encompassing 211 The GBM scrutinized using Inverse Variance Weighted...
The intestine is the largest digestive and immune organ in human body, with an intact intestinal mucosal barrier. Bifidobacterium longum specific gut commensals colonized for boosting immunity to defend against injury. In LPS-induced injury model, BL-10 was suggested boost immune. Detailly, compared mice, BL10 group significantly reduced (jejunum, ileum, colon) tissue injury, pro-inflammatory cytokines (TNF-α, IFN-γ, IL-2, IL-6, IL-17, IL-22, IL-12) levels myeloperoxidase activities....
Colon cancer is the most common type of malignant tumor. The cytotoxicity effect lactic acid bacteria may be active by inhibiting cell proliferation, producing anticancer compounds, and inducing apoptosis in cells, but mechanism unclear. Our previous study revealed that Lactobacillus acidophilus KLDS1.0901 has good probiotic properties. In this study, We screened out highest inhibition rate L. assessed effects on proliferation HT-29, Caco-2, IEC-6 cells. Then, HT-29 cells was studied when...
The peroxisome proliferator-activated receptors (PPAR) are members of the nuclear hormone receptor superfamily. Peroxisome receptor-gamma is regarded as a "master regulator" adipocyte differentiation in mammals. current study was designed to investigate function and regulatory mechanism PPARgamma chicken adipogenesis by RNA interference. Preadipocytes were isolated from abdominal fat tissue 12-d-old chickens cultured. Small-interference (siPPARgamma) synthesized vitro transcription...
We systematically investigated the<italic>in vitro</italic>and<italic>in vivo</italic>antioxidant potential of EPS produced by<italic>Lactobacillus helveticus</italic>KLDS1.8701.
Commensal intestinal bacteria play key roles in regulating host immune tolerance; however, bacterial strains and related metabolites directly involved this regulation are largely unknown. Here, using a mouse model of dextran sulfate sodium (DSS)-induced colitis combined with different antibiotic treatment, Enterobacter ludwigii, abundant microbiota mice treated metronidazole, is screened out to have prophylactic therapeutic effects on DSS-induced or without the presence complex bacteria. E....
N6-methyladenosine (m6A) modification is a key methylation involved in reproductive processes. Myostatin gene editing (MT) cattle known to enhance muscle mass and productivity. However, the changes m6A MT bull sperm remain poorly understood. In wild-type (WT) groups, we identified 25,542 22,253 peaks, respectively, mainly concentrated coding sequence (CDS) 3′ untranslated region (UTR) of genes. The group showed an increase transcription, but there was no significant difference overall peaks...
Abstract Tribovoltaic nanogenerators (TVNGs) are an advanced technology that can convert friction energy into electrical via semiconductor tribovoltaic effect, which offers the advantages of high charge density and direct current (DC) output. However, characteristic components TVNG outputs relatively few, is not conducive to monitoring periodic motions. This study proposes a compound motion‐mode nanogenerator (CM‐TVNG) for gear transmission system using gears' unique meshing form. The...
Randomised trials have described the benefits of adalimumab [ADA] for ulcerative colitis [UC]; however, few data are available on health-related quality life [HRQL] and health care costs in clinical practice. InspirADA, a multicentre, prospective study, evaluated effect ADA patients with moderate to severe UC treated according usual Outcomes assessed were: Simple Clinical Colitis Activity Index [SCCAI] response/remission rates; changes HRQL; all-cause direct costs; UC-related indirect from...
Inflammatory bowel disease (IBD) is a chronic immune-related disease, which can occur through the dysfunction of immune system caused by imbalance gut microbiota. Previous studies have reported beneficial effects Bifidobacterium on colitis, while related mechanisms behind these not been fully elucidated. The aim our study to investigate alleviation effect animalis subsp. lactis XLTG11 (B. lactis) dextran sulfate sodium (DSS)-induced colitis and its potential mechanism. results showed that B....
Myostatin (MSTN), a growth and differentiation factor, plays an important role in regulating skeletal muscle development. MSTN knockout (MSTN-KO) leads to hypertrophy regulates metabolic homeostasis. Moreover, is also detected smooth muscle. However, the effect of MSTN-KO on has not yet been reported. In this study, combined metabolome transcriptome analyses were performed investigate transcriptional profiling esophageal muscles Chinese Luxi Yellow cattle (n = 5, 24 months, average body...
Cow mastitis, which significantly lowers milk quality, is mainly caused by pathogenic bacteria such as E. coli . Previous studies have suggested that lactic acid can antagonistic effects on cause mastitis. In the current study, we evaluated in vitro and vivo alleviative of L. plantarum KLDS 1.0344 mastitis treatment. antibacterial experiments were performed using bovine mammary epithelial cell (bMEC), followed involving mouse models. results indicate was primary substance inhibiting...
In recent years, yogurt has been one of the most popular fermented dairy products and is sold worldwide. this study, pH titrated acid changes 4 strains Lactobacillus delbrueckii ssp. bulgaricus milk during storage were detected. The difference between L. KLDS1.1011 KLDS1.0207 was significant, with latter exhibiting reduced acidity levels. Therefore, we determined complete genome sequence 2 strains. Then expression specific genes common related to glucose metabolism proteolysis detected by...
Sugarcane molasses are considered a potential source for bioethanol's commercial production because of its availability and low market price. It contains high concentrations fermentable sugars that can be directly metabolized by microbial fermentation. Heterofermentative lactic acid bacteria, especially Lactiplantibacillus casei, have to biocatalyst in ethanol they characterized strong abilities carbohydrate metabolism, synthesis, alcohol tolerance. This study aimed evaluate the feasibility...