A5100692776- Probiotics and Fermented Foods
- Proteins in Food Systems
- Food composition and properties
- Gut microbiota and health
- Laser Design and Applications
- Microbial Metabolites in Food Biotechnology
- Enzyme Production and Characterization
- Plant-Microbe Interactions and Immunity
- Spectroscopy and Laser Applications
- Insect Resistance and Genetics
- Meat and Animal Product Quality
- Protein Hydrolysis and Bioactive Peptides
- Polysaccharides Composition and Applications
- Genomics and Phylogenetic Studies
- Infant Nutrition and Health
- Chemical Synthesis and Analysis
- Food Quality and Safety Studies
- Insect and Pesticide Research
- Biosensors and Analytical Detection
- Plant Pathogens and Fungal Diseases
- Mycotoxins in Agriculture and Food
- Advanced biosensing and bioanalysis techniques
- Plant Pathogens and Resistance
- Solid State Laser Technologies
- Computational Drug Discovery Methods
Tarim University
2006-2025
Xinjiang Production and Construction Corps
2009-2025
Northeast Agricultural University
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2002-2024
Beijing Technology and Business University
2018-2024
Sun Yat-sen University
2023-2024
Weifang University
2024
Guangxi Normal University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Tianjin University
2024
Deposition of hyperphosphorylated and aggregated tau protein in the central nervous system is characteristic Alzheimer disease other tauopathies. Tau subject to <i>O</i>-linked <i>N</i>-acetylglucosamine (<i>O</i>-GlcNAc) modification, <i>O</i>-GlcNAcylation has been shown influence phosphorylation aggregation. Inhibition <i>O</i>-GlcNAcase (OGA), enzyme that removes <i>O</i>-GlcNAc moieties, a novel strategy attenuate formation pathologic tau. Here we described vitro vivo pharmacological...
Abstract Background As artificial intelligence (AI) increasingly integrates into medical education, its specific impact on the development of clinical skills among pediatric trainees needs detailed investigation. Pediatric training presents unique challenges which AI tools like ChatGPT may be well-suited to address. Objective This study evaluates effectiveness ChatGPT-assisted instruction versus traditional teaching methods trainees’ performance. Methods A cohort ( n = 77) was randomly...
Liraglutide is a glucagon-like peptide-1 analogue that stimulates insulin secretion and improves β-cell function. However, it not clear whether liraglutide achieves its glucose lowering effect only by known effects or other as yet unknown mechanisms are involved. The aim of this study was to examine the on Fibroblast growth factor-21 (FGF-21) activity in High-fat diet (HFD) fed ApoE(-/-) mice with adiponectin (Acrp30) knockdown.HFD-fed were treated adenovirus vectors expressing shAcrp30...
The dominating non-volatile taste compounds in commercial brewed soy sauces were determined by HPLC and evaluated on the contributions to overall taste. Aspartic acid glutamic accounted for 8.77 147.98 mg/mL ten samples. Lactic (ranging from 0.83 13.19 mg/mL) pyroglutamic 0 12.80 dominant organic acids, contributing acidity ensuring a balance of sauces. 5ʹ-Inosine monophosphate was most abundant nucleotide, followed 5ʹ-guanosine monophosphate, they 0.30 3.54 According determination sauce...
Intestinal epithelial barrier function is closely associated with the development of many intestinal diseases. Heat-killed Lacticaseibacillus paracasei (HK-LP) has been shown to improve health and enhance immunity. However, HK-LP in still unclear. This study characterized inflammatory effects seven (1 μg/mL) on using lipopolysaccharide (LPS) (100 μg/mL)-induced Caco-2 cells. In this study, 6105, 6115, 6235 were selected, their modulation factors tight junction protein expression (claudin-1,...
Myocardial infarction (MI), including ST-segment elevation MI (STEMI) and non-ST-segment (NSTEMI), is still a leading cause of death worldwide. Metabolomics technology was used to explore differential metabolites (DMs) as potential biomarkers for early diagnosis STEMI NSTEMI. In the study, 2531 metabolites, 1925 DMs, were discovered. selected 27 14 successfully verified in new cohort, AUC values all above 0.8. There 10 group, namely L-aspartic acid, L-acetylcarnitine, acetylglycine,...
Avian pathogenic Escherichia coli (APEC) biofilm formation has led to increased antibiotic resistance, presenting a significant challenge for the prevention and control of disease. While certain D-amino acids (D-AAs) have been shown inhibit various bacterial biofilms, role in APEC biofilms remains unexplored. This study investigates effects 19 different D-AAs on clinically isolated biofilm. The results showed that D-tyrosine (D-Tyr), D-leucine (D-Leu), D-tryptophan (D-Trp), D-methionine...
Tomato gray mold disease, caused by Botrytis cinerea, is a serious disease in tomato. Clonostachys rosea an antagonistic microorganism to B. cinerea. To investigate the induced resistance mechanism of C. rosea, we examined effects these microorganisms on tomato leaves, along with changes activities three defense enzymes (PAL, PPO, GST), second messengers (NO, H2O2, O2−) and phytohormones (IAA, ABA, GA3, ZT, MeJA, SA C2H4). Compared control, all treatments higher levels PAL, PPO GST activity...
Abstract BACKGROUND As a potential health hazard, 5‐hydroxymethylfurfural (HMF) has been detected in thermally processed foods high sugar and amino acids. In order to analyze HMF quantitatively investigate the kinetics of its formation, high‐performance liquid chromatography was employed determine content six sugar–amino acid thermal reaction models. RESULTS models, formation significantly affected by composition, pH value heating conditions. increased with increasing (cysteine excepted)...
Abstract BACKGROUND Oil‐in‐water (O/W) emulsions are thermodynamically unstable and easily oxidized. Recently, protein hydrolysates have been used to enhance the emulsifying oxidative stability of emulsions. High‐pressure processing (HPP) enzymatic soy isolate higher bioactivities. The objective study was investigate effects various hydrolysate (SPIH) concentrations obtained during different 4 h pressure treatments on improving myofibrillar (MP) RESULTS Emulsions with mg mL −1 SPIH at 200...
The phenotypic modulation of vascular smooth muscle cells (VSMCs) plays a pivotal role in hypertension-induced changes including remodeling. precise mechanisms underlying VSMC remain elusive. Here we test the peroxisome proliferator-activated receptor (PPAR)-γ during hypertension. Both spontaneously hypertensive rat (SHR) aortas and SHR-derived VSMCs exhibited reduced PPAR-γ expression excessive identified by contractile proteins, α-smooth actin (α-SMA) 22α (SM22α), enhanced proliferation...