A5019927985- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Peptidase Inhibition and Analysis
- Pancreatic function and diabetes
- Neuroscience and Neuropharmacology Research
- Monoclonal and Polyclonal Antibodies Research
- Respiratory viral infections research
- Neurotransmitter Receptor Influence on Behavior
- Advanced Radiotherapy Techniques
- Climate Change Policy and Economics
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Lung Cancer Research Studies
- Bone health and treatments
- Nanoplatforms for cancer theranostics
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Treatment and Management
- Nuclear Physics and Applications
- Click Chemistry and Applications
- Glycosylation and Glycoproteins Research
- Cell Image Analysis Techniques
United States Military Academy
2005-2020
Merck & Co., Inc., Rahway, NJ, USA (United States)
2006-2020
Zhuhai People's Hospital
2019
University of Colorado Anschutz Medical Campus
2019
Brookhaven National Laboratory
2005
University of California, Los Angeles
2000-2003
The University of Texas at Austin
1996
5'-Adenosine monophosphate-activated protein kinase (AMPK) is a master regulator of energy homeostasis in eukaryotes. Despite three decades investigation, the biological roles AMPK and its potential as drug target remain incompletely understood, largely because lack optimized pharmacological tools. We developed MK-8722, potent, direct, allosteric activator all 12 mammalian complexes. In rodents rhesus monkeys, MK-8722-mediated activation skeletal muscle induced robust, durable,...
Programmed death ligand 1 (PD-L1) is an immune regulatory that binds to the T-cell check point programmed 1. Tumor expression of PD-L1 correlated with suppression and poor prognosis. It also therapeutic efficacy inhibitors. In vivo imaging may enable real-time follow-up changing heterogeneity evaluation across tumors in same subject. We have radiolabeled PD-L1-binding Affibody molecule NOTA-ZPD-L1_1 18F evaluated its vitro binding affinity, targeting, specificity. Methods: The affinity...
Positron emission tomography (PET) using radiolabeled biomolecules is a translational molecular imaging technology that increasingly used in support of drug development.Current methods for radiolabeling with fluorine-18 are laborious and require multistep procedures moderate labeling yields.The Al 18 F-labeling strategy involves chelation aqueous medium aluminum mono[ F]fluoride ({Al F} 2+ ) by suitable chelator conjugated to biomolecule.However, the need elevated temperatures (100-120 °C)...
Deposition of hyperphosphorylated and aggregated tau protein in the central nervous system is characteristic Alzheimer disease other tauopathies. Tau subject to <i>O</i>-linked <i>N</i>-acetylglucosamine (<i>O</i>-GlcNAc) modification, <i>O</i>-GlcNAcylation has been shown influence phosphorylation aggregation. Inhibition <i>O</i>-GlcNAcase (OGA), enzyme that removes <i>O</i>-GlcNAc moieties, a novel strategy attenuate formation pathologic tau. Here we described vitro vivo pharmacological...
Folate-receptor-targeted PET radiotracers can potentially serve as versatile imaging agents for the diagnosis, staging, and prediction of response to therapy patients with folate-receptor (FR)-expressing cancers. Because current FR-targeted reagents be compromised by complex labeling procedures, low specific activities, poor radiochemical yields, or unwanted accumulation in FR negative tissues, we have undertaken design an improved folate-PET agent that might more amenable clinical...
The folate receptor (FR) has been established as a promising target for imaging and therapy of cancer (FR-α), inflammation, autoimmune diseases (FR-β). Several based PET radiotracers have reported in the literature, but an 18F-labeled folate-PET agent with optimal properties clinical translation is still lacking. In present study, we report design preclinical evaluation folate-PEG12-NOTA-Al18F (1), new improved potential applications. Radiochemical synthesis 1 was achieved via one-pot...
Abstract Purpose Programmed cell death-1 receptor (PD-1) and its ligand (PD-L1) are the targets for immunotherapy in many cancer types. Although PD-1 blockade has therapeutic effects, efficacy differs between patients. Factors contributing to this variability PD-L1 expression levels immune cells present tumors. However, it is not well understood how tumor microenvironment impacts response. Thus, imaging of PD-1-expressing interest. This study aims evaluate biodistribution Zirconium-89 ( 89...
Respiratory syncytial virus (RSV) is the most common viral cause of bronchiolitis and pneumonia in children twelve months age or younger a significant lower respiratory disease older adults. As various clinical preclinical candidates advance, cotton rats (Sigmodon hispidus) non-human primates (NHP) continue to play valuable role RSV vaccine development, since both animals are semi-permissive human (HRSV). However, appropriate utilization models critical avoid mis-interpretation findings....
This work describes a fully 3D statistical image reconstruction for the RatCAP (Rat Conscious Animal PET) using Monte Carlo based system matrix. The consists of 12 Iutetium oxyorthosilicate (LSO)-avalanche photodiode (APD) detector blocks arranged in ring 41.2 mm diameter. Due to small diameter and low number total lines response (LORs), size complete matrix is comparison typical animal scanner. allows incorporation an accurate, RatCAP-specific physical model with inclusion crystal...
The cathepsin K (CatK) enzyme is abundantly expressed in osteoclasts, and CatK inhibitors have been developed for the treatment of osteoporosis. In our effort to support discovery clinical evaluations a inhibitor, we sought discover radioligand determine target engagement by therapeutic candidates using positron emission tomography (PET). L-235, potent selective was labeled with carbon-11. PET imaging studies recording baseline distribution [11 C]L-235, chase blocking inhibitor MK-0674 were...
A bipolar, high-current (10 000 A) pulse generator, used to magnetically saturate thin films during spin-polarized electron and dynamic response measurements, is described. Bipolar operation achieved by discharging a bank of capacitors through selected pairs high-power silicon-controlled rectifiers connected coil in an H bridge configuration. The generator can be controlled either manually or means computer.