A5003192635- Cancer Immunotherapy and Biomarkers
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- CAR-T cell therapy research
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Maternal Mental Health During Pregnancy and Postpartum
- Chemokine receptors and signaling
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Tryptophan and brain disorders
- Political and Economic history of UK and US
- Cancer Research and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiac and Coronary Surgery Techniques
- Colorectal Cancer Treatments and Studies
- Cardiac Ischemia and Reperfusion
- Pneumocystis jirovecii pneumonia detection and treatment
- Blood disorders and treatments
- Pneumonia and Respiratory Infections
- Anodic Oxide Films and Nanostructures
- Antibiotic Resistance in Bacteria
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pregnancy and Medication Impact
University Medical Center Groningen
2016-2021
University of Groningen
2018-2021
Isala
2014
Cardiovascular Institute of the South
2013
Icahn School of Medicine at Mount Sinai
2013
Wilhelmina Children's Hospital
2009
University Medical Center Utrecht
2009
•89Zr-pembrolizumab PET imaging is safe and feasible in patients with metastatic melanoma NSCLC.•89Zr-pembrolizumab uptake tumor lesions correlates response to PD-1 antibody treatment.•Patients high 89Zr-pembrolizumab experience longer progression-free survival overall survival. BackgroundProgrammed cell death protein 1 (PD-1) treatment standard of care for non-small-cell lung cancer (NSCLC). Accurately predicting which will benefit currently not possible. Tumor biodistribution the might...
Recently, N-(4-18F-fluorobenzoyl)-interleukin-2 (18F-FB-IL2) was introduced as a PET tracer for T cell imaging. However, production is complex and time-consuming. Therefore, we developed 2 radiolabeled IL2 variants, namely aluminum 18F-fluoride-(restrained complexing agent)-IL2 (18F-AlF-RESCA-IL2) 68Ga-gallium-(1,4,7-triazacyclononane-4,7-diacetic acid-1-glutaric acid)-IL2 (68Ga-Ga-NODAGA-IL2), compared their in vitro vivo characteristics with 18F-FB-IL2. Methods: Radiolabeling of...
Background To better predict response to immune checkpoint therapy and toxicity in healthy tissues, insight the vivo behavior of targeting monoclonal antibodies is essential. Therefore, we aimed study pharmacokinetics whole-body distribution zirconium-89 ( 89 Zr) labeled programmed cell death protein-1 (PD-1) pembrolizumab with positron-emission tomography (PET) humanized mice. Methods Humanized (huNOG) non-humanized NOG mice were xenografted human A375M melanoma cells. PET imaging was...
<sup>18</sup>F-BMS-986192, an adnectin-based human programmed cell death ligand 1 (PD-L1) tracer, was developed to noninvasively determine whole-body PD-L1 expression by PET. We evaluated the usability of <sup>18</sup>F-BMS-986192 PET detect different levels and therapy-induced changes in tumors. <b>Methods:</b> In vitro binding assays with were performed on tumor lines total cellular membrane protein levels. Subsequently, imaging immunodeficient mice xenografted these lines. The treated...
Immune checkpoint inhibitors can induce a T cell-mediated anti-tumor immune response in patients with melanoma. Visualizing cell activity using positron emission tomography (PET) might allow early insight into treatment efficacy. Activated tumor-infiltrating cells express the high-affinity interleukin-2 receptor (IL-2R). Therefore, we performed pilot study, fluorine-18-labeled IL-2 ([18F]FB-IL2 PET), to evaluate whether treatment-induced be detected.Patients metastatic melanoma received ~...
Abstract Purpose Programmed cell death-1 receptor (PD-1) and its ligand (PD-L1) are the targets for immunotherapy in many cancer types. Although PD-1 blockade has therapeutic effects, efficacy differs between patients. Factors contributing to this variability PD-L1 expression levels immune cells present tumors. However, it is not well understood how tumor microenvironment impacts response. Thus, imaging of PD-1-expressing interest. This study aims evaluate biodistribution Zirconium-89 ( 89...
The aim of this study was to test the hypothesis that trimethoprim/sulfamethoxazole selects for integron-positive and multidrug-resistant Enterobacteriaceae in intestinal flora. During 1 year follow-up, antibiotic susceptibility presence integrons were determined faecal isolated from 99 children with chronic active otitis media, randomly assigned treatment or placebo (http://www.clinicaltrials.gov/; trial registration number NCT00189098). At 6 12 weeks 32 (91%) 24 (67%) group carried...
Molecular imaging of immune cells might be a potential tool for response prediction, treatment evaluation and patient selection in inflammatory diseases as well oncology. Targeting interleukin-2 (IL2) receptors on activated T-cells using positron emission tomography (PET) with N-(4-[18F]fluorobenzoyl)-interleukin-2 ([18F]FB-IL2) could such strategy. This paper describes the challenging translation partly manual labeling [18F]FB-IL2 preclinical studies into an automated procedure following...
What is known and objective Depression during pregnancy common includes risks for mother child. Pharmacokinetics of venlafaxine may be changed pregnancy. This study aimed to describe changes in metabolic ratios concentrations its main metabolite O-desmethylvenlafaxine after Methods To this, we used data from our compliance Antidepressants During Pregnancy (the ADAP study) investigate the course period post-partum. Results discussion We found that concentration significantly when compared...
Abstract Introduction: Activation of T-cells is accompanied by a strong up-regulation interleukin-2 (IL2) receptor (CD25). Therefore PET imaging IL2 receptors might be suitable biomarker for T-cell activation. 18F-IL2 could detect CD25-positive and the migration these to distant sites inflammation in SCID mice subcutaneously injected with human peripheral blood mononuclear cells1 NOD insulitis. Also correlation was found between accumulation number activated immune-competent rats.2 In tumor...