A5022089265- Cardiac Imaging and Diagnostics
- Medical Imaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- S100 Proteins and Annexins
- Acute Myocardial Infarction Research
- Radiopharmaceutical Chemistry and Applications
- Advanced MRI Techniques and Applications
- Cell death mechanisms and regulation
- Coronary Interventions and Diagnostics
- Cell Adhesion Molecules Research
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Protease and Inhibitor Mechanisms
- Aortic aneurysm repair treatments
- Cardiac electrophysiology and arrhythmias
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Drug Transport and Resistance Mechanisms
- Cardiac Structural Anomalies and Repair
- Cardiovascular Health and Disease Prevention
- Orthopedic Infections and Treatments
- Angiogenesis and VEGF in Cancer
- Phagocytosis and Immune Regulation
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
University Medical Center Groningen
2015-2024
University of Groningen
2014-2024
Erasmus MC
2004-2023
Royal Prince Alfred Hospital
2016-2018
University of Pecs
2018
Vanderbilt University
2018
Erasmus University Rotterdam
1994-2017
Icahn School of Medicine at Mount Sinai
2017
Cardiovascular Institute Hospital
2016
Royal Brompton Hospital
2016
In atherosclerotic plaques, the risk of rupture is increased at sites macrophage accumulation. Activated macrophages express folate receptor-β (FR-β), which can be targeted by coupled to radioactive ligands visualize vulnerability. The aim this study was explore presence activated in human plaques (99m)Tc-folate imaging and evaluate whether technique discriminate between an M1-like M2-like phenotype.Carotid endarterectomy specimens 20 patients were incubated with (99m)Tc-folate, imaged using...
18F-NaF positron emission tomography (PET) targets microcalcifications. We compared in vitro microPET assessed uptake between culprit and non-culprit human carotid plaques. Furthermore, we with calcification visualized on microcomputed (microCT). Carotid plaques from stroke patients undergoing surgery were incubated scanned using a microCT scan. The average PET was expressed as percentage of the incubation dose per gram (%Inc/g). volume interest (VOI) CT VOI. 23 (17 culprit, 6 non-culprit)...
Previous interim data from a phase I study of AKS-452, subunit vaccine comprising an Fc fusion the respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein receptor binding domain (SP/RBD) emulsified in water-in-oil adjuvant, Montanide™ ISA 720, suggested good safety and immunogenicity profile healthy adults. This was completed two dosing regimens were further evaluated this II study.This randomized, open-labelled, parallel group conducted at single site The Netherlands with 52 adults...
<h3>Introduction</h3> The terms 'precision medicine' and 'personalised have become key in health-related research science-related public communication. However, the application of these two concepts their interpretation various disciplines are heterogeneous, which also affects translation awareness. This leads to confusion regarding use distinction concepts. Our aim is provide a snapshot current understanding <h3>Methods analysis</h3> study will Rodgers' evolutionary concept analysis...
FDG-PET can be used to identify vulnerable plaques in atherosclerotic disease. Clinical camera systems are restricted terms of resolution for the visualization detailed inflammation patterns smaller vascular structures. The aim study is evaluate possible added value a high-resolution microPET system excised carotid using FDG.
Background: Invasive imaging modalities have shown restoration of vasomotion, prevention restenosis and most importantly increase in lumen area between 6-months 2-years after first-generation everolimus-eluting bioresorbable vascular scaffold (Absorb BVS) implantation. Our aim was to assess whether these positive findings were sustained the long-term.
In this study, the potential of matrix metalloproteinase (MMP) sense for detection atherosclerotic plaque instability was explored. Secondly, expression MMPs by macrophage subtypes and smooth muscle cells (SMCs) investigated.Twenty-three consecutive plaques removed during carotid endarterectomy were incubated in MMPSense™ 680 imaged with IVIS® Spectrum. mRNA levels MMPs, markers, SMCs determined specimens, vitro differentiated M1 M2 macrophages.There a significant difference between...
Hospital length of stay after acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (pPCI) has reduced, resulting in more limited patient education during admission. Therefore, systematic participation cardiac rehabilitation (CR) become essential. We aimed to identify patient-related factors that are associated and completion a CR programme.We identified 3,871 consecutive AMI patients who underwent pPCI between 2003 2011. These were linked the database...
The clinical feasibility of noninvasive imaging interstitial alterations after myocardial infarction (MI) was assessed using a technetium-99m-labeled RGD peptide (RIP). In experimental studies, RIP has been shown to target integrins associated with collagen-producing myofibroblasts (MFB). Ten patients underwent perfusion (MPI) within the first week MI. At 3 and 8 weeks MI, administered intravenously SPECT images acquired for imaging. compared initial MPI extent scar formation defined by late...
Background. Vertebral fracture assessment (VFA) using dual-energy X-ray absorptiometry can visualize abdominal aortic calcification (AAC). AAC correlates with total atherosclerosis burden. We questioned whether VFA-detected could be used for cardiovascular risk assessment.Methods. VFA images of 2,500 subjects were evaluated to detect and score (n = 164). A random age- gender-matched set 325) without served as control group. Patients prior disease or procedures excluded. Base-line factors...