A5078183093- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Medical Imaging Techniques and Applications
- Virus-based gene therapy research
- CAR-T cell therapy research
- Radiomics and Machine Learning in Medical Imaging
- Viral Infectious Diseases and Gene Expression in Insects
- Glioma Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Nonmelanoma Skin Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Herpesvirus Infections and Treatments
- Lung Cancer Research Studies
- Breast Cancer Treatment Studies
- Advanced MRI Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Genetic factors in colorectal cancer
- Cardiac pacing and defibrillation studies
- CNS Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Medical Imaging and Pathology Studies
The Netherlands Cancer Institute
2016-2025
Cancer Genomics Centre
2021
Leiden University Medical Center
2002-2013
Centre Hospitalier de Saint-Quentin
2010
Leiden University
2001
Abstract Background Combining radioactive colloids and a near-infrared (NIR) fluorophore permits preoperative planning intraoperative localization of deeply located sentinel lymph nodes (SLNs) with direct optical guidance by single lymphatic tracer. The aim this clinical trial was to evaluate optimize hybrid NIR fluorescence tracer for SLN detection in patients breast cancer. Methods Patients cancer undergoing biopsy were enrolled. day before surgery, periareolar injection indocyanine green...
Talimogene laherparepvec (T‐VEC) is a modified herpes simplex virus, type 1 (HSV‐1), which can be administered intralesionally in patients with stage IIIB/C‐IVM1a unresectable melanoma (EMA label). The phase 3 OPTiM registration study showed an overall response rate (ORR) of 26%. Since December 2016, 48 eligible started treatment at the Netherlands Cancer Institute. We included 26 this follow up time ≥6 months, reporting Overall Response Rate (ORR), Disease Control (DCR), Adverse Events...
•89Zr-pembrolizumab PET imaging is safe and feasible in patients with metastatic melanoma NSCLC.•89Zr-pembrolizumab uptake tumor lesions correlates response to PD-1 antibody treatment.•Patients high 89Zr-pembrolizumab experience longer progression-free survival overall survival. BackgroundProgrammed cell death protein 1 (PD-1) treatment standard of care for non-small-cell lung cancer (NSCLC). Accurately predicting which will benefit currently not possible. Tumor biodistribution the might...
The aim of the current study was to evaluate relationship between site latest mechanical activation as assessed with gated myocardial perfusion SPECT (GMPS), left ventricular (LV) lead position and response cardiac resynchronization therapy (CRT).The patient population consisted consecutive patients advanced heart failure in whom CRT currently indicated. Before implantation, 2-D echocardiography GMPS were performed. performed assess LV end-systolic volume (LVESV), end-diastolic (LVEDV)...
Objective: To evaluate the potency of short-term neoadjuvant cytoreductive therapy with dabrafenib plus trametinib ( BRAF and MEK inhibitor) to allow for radical surgical resection in patients unresectable locally advanced melanoma. Summary Background Data: Approximately 5% stage III melanoma presents disease, making standard care followed by adjuvant systemic impossible. Although targeted has shown promising results resectable melanoma, its enable primarily is still unclear. Methods: In...
<title>Abstract</title> <bold>Background: </bold>[<sup>18</sup>F]FDG PET/CT plays a crucial role in evaluating cancer patients and assessing treatment response, including BRAF-mutated melanoma. Metabolic tumor volume (MTV) total lesion glycolysis (TLG) have emerged as promising alternatives to standardized uptake value (SUV)-based measures for assessment. This study evaluates the predictive of SUVpeak, MTV, TLG predicting progression-free survival (PFS) advanced melanoma treated with...
The outcome of screening and prophylactic surgery in 269 women at high risk hereditary ovarian cancer is reported. Screening was performed using transvaginal ultrasound serum CA125 testing. Mean follow-up 26 months (583 person-years). A total 113 (42%) had a pathogenic BRCA1 or BRCA2 mutation, 127 (47%) underwent salpingo-oophorectomy. No occult cancers were found. In eight having both elevated levels abnormal findings, malignancy Four these (one borderline, one stage Ia, IIIb, IIIc...
Ipilimumab is a human monoclonal antibody directed against receptor expressed on activated T-lymphocytes (CTLA-4). Binding to this induces T-cell activation tumor cells. A 77-year-old man with stage IV metastatic melanoma was treated ipilimumab. F-FDG PET-CT performed for response evaluation revealed intense uptake in the pituitary gland. Two weeks later, biochemical parameters altered confirming hypophysitis. Treatment of hypophysitis started, and shortly thereafter, normalized. Follow-up...
Abstract Background The role of 18 F‐fluorodeoxyglucose positron emission tomography/computed tomography ( F‐FDG PET/CT) in the evaluation retroperitoneal sarcomas is poorly defined. We evaluated correlation maximum standardized uptake value (SUVmax) with pathologic tumor grade surgical specimen primary dedifferentiated liposarcoma (DDLPS) and leiomyosarcoma (LMS). Methods Patients above histological subtypes three participating institutions preoperative PET/CT scan histopathological...
The aim of the current study was to evaluate feasibility phase analysis on gated myocardial perfusion SPECT (GMPS) for assessment left ventricular (LV) diastolic dyssynchrony in a head-to-head comparison with tissue Doppler imaging (TDI).The population consisted patients end-stage heart failure New York Heart Association functional class III or IV reduced LV ejection fraction ≤ 35%. calculated using TDI as maximal time delay between early peak velocities two opposing ventricle walls...
Fluorine-18-methyl-choline (F18-choline) PET/computed tomography (CT) is routinely performed in our hospital for patients with significantly increased or rapidly increasing prostate-specific antigen (PSA) levels to detect and localize recurrent prostate carcinoma. We observed uptake of this PET tracer mediastinal lymph nodes a significant number patients. The aim study was assess the frequency finding determine whether it correlated tumour nontumour-related aspects.A total 48 consecutive men...
The aim of this study was to associate and predict B-rapidly accelerated fibrosarcoma valine 600 (BRAFV600) mutation status with both conventional radiomics <sup>18</sup>F-FDG PET/CT features, while exploring several methods feature selection in melanoma radiomics. <b>Methods:</b> Seventy unresectable stage III–IV patients who underwent a baseline scan were identified. Patients assigned the BRAFV600 group or BRAF wild-type according mutational status. uptake quantification performed by...
The canonical Wnt pathway plays a key regulatory role in osteoblastogenesis and bone mass acquisition through its main effector, β-catenin. Adenomatous polyposis coli (APC) represents the intracellular gatekeeper of β-catenin turnover, heterozygous germ-line mutations APC gene cause familial adenomatous (FAP). Whether affect has not been previously investigated. We conducted cross-sectional study evaluating skeletal status FAP patients with documented mutation. Twenty-two mean age 42 years...
We report a retrospective study on serum and cerebrospinal fluid (CSF) alpha-fetoprotein (AFP) beta-human chorionic gonadotropin (betahCG) determination in series of 30 patients bearing intracranial germ cell tumors. At diagnosis five had high CSF AFP levels. No patient positive negative or vice versa. Twelve betahCG levels above 5 mlU/mL, eight only CSF, ten were completely negative. During treatment follow-up both markers accurate indicators the response to therapy, decreasing rapidly...
We report a retrospective study on serum and cerebrospinal fluid (CSF) alpha-fetoprotein (AFP) β-human chorionic gonadotropin (βhCG) determination in series of 30 patients bearing intracranial germ cell tumors. At diagnosis five had high CSF AFP levels. No patient positive negative or vice versa. Twelve βhCG levels above 5 mIU/mL, eight only CSF, ten were completely negative. During treatment follow-up both markers accurate indicators the response to therapy, decreasing rapidly often...
Sentinel node biopsy is a widely used staging procedure in melanoma. It usually performed using the triple technique: lymphatic mapping after injection of radiopharmaceutical, blue dye injection, and use gamma probe. Blue offers visual confirmation location sentinel lymph (SN). There are some disadvantages such as blurring surgical field, skin coloring, possible anaphylactic reactions. We aimed to answer question whether patent truly necessary for correct intraoperative identification SN....
AJCC stage IIIB and IIIC melanoma patients are at risk for disease relapse or progression. The advent of effective systemic therapies has made curative treatment progressive a possibility. As resection oligometastatic can confer survival benefit as immunotherapy is possibly most in low tumor load setting, there likely to early detection aim this pilot study was evaluate PET/computed tomography (CT) surveillance schedule resected melanoma. From 1-2015, our institution underwent 6-monthly with...
Patients with palpable melanoma groin metastases have a poor prognosis. There is debate whether combined superficial and deep dissection (CGD) necessary or if (SGD) alone sufficient. The aim of this study was to analyze risk factors for pelvic nodal involvement in retrospective, multicenter cohort metastases. This could aid the development an algorithm selective surgery future. related 209 therapeutic CGDs from four tertiary centers Netherlands (1992–2013), selected based on complete...
The outcome of screening and prophylactic surgery in 269 women at high risk hereditary ovarian cancer is reported. Screening was performed using transvaginal ultrasound serum CA125 testing. Mean follow-up 26 months (583 person-years). A total 113 (42%) had a pathogenic BRCA1 or BRCA2 mutation, 127 (47%) underwent salpingo-oophorectomy. No occult cancers were found. In eight having both elevated levels abnormal findings, malignancy Four these (one borderline, one stage Ia, IIIb, IIIc...