A5020898759- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced X-ray and CT Imaging
- Atomic and Subatomic Physics Research
- Particle Detector Development and Performance
- Radiomics and Machine Learning in Medical Imaging
- CCD and CMOS Imaging Sensors
- Chronic Disease Management Strategies
- Nuclear Physics and Applications
- Computational Drug Discovery Methods
- Prostate Cancer Diagnosis and Treatment
- COVID-19 and Mental Health
- Health, Environment, Cognitive Aging
- Prostate Cancer Treatment and Research
- Down syndrome and intellectual disability research
- Menopause: Health Impacts and Treatments
- Machine Learning in Healthcare
- Medical Image Segmentation Techniques
- Acute Myocardial Infarction Research
- Advanced Neuroimaging Techniques and Applications
- Stress Responses and Cortisol
Vanderbilt University Medical Center
2014-2024
Dascena (United States)
2021-2022
North Medical Center
2017
Vanderbilt University
2007-2016
Stony Brook University
2003-2006
State University of New York
2003-2005
Brookhaven National Laboratory
2002-2004
Abstract Depression is associated with markers of accelerated aging, but it unclear how this relationship changes across the lifespan. We examined whether a brain-based measure aging differed between depressed and never-depressed subjects adult lifespan was related to cognitive performance disability. applied machine-learning approach that estimated brain age from structural MRI data in two cohorts, respectively 170 midlife adults 154 older enrolled studies common entry criteria. Both...
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Anesthesia is currently required for positron emission tomography (PET) studies of the animal brain in order to eliminate motion artifacts. However, anesthesia profoundly affects neurological state animal, complicating interpretation PET data. Furthermore, it precludes use study during normal behavior. The rat conscious tomograph (RatCAP) designed need studies. It a miniaturized full-ring scanner that attached directly head, imaging nearly entire brain. RatCAP utilizes arrays 2 mm /spl...
Evaluating the symptomatic progression of mild cognitive impairment (MCI) caused by Alzheimer disease (AD) is practically accomplished tracking performance on tasks, such as Disease Assessment Scale’s subscale (ADAS_cog), Mini-Mental Status Examination (MMSE), and Functional Activities Questionnaire (FAQ). The longitudinal relationships between decline metabolic function assessed using <sup>18</sup>F-FDG PET are needed to address both biologic state in individual subjects. We conducted an...
Abstract Background Semiquantitative methods such as the standardized uptake value ratio (SUVR) require normalization of radiotracer activity to a reference tissue monitor changes in accumulation amyloid-β (Aβ) plaques measured with positron emission tomography (PET). The objective this study was evaluate effect test–retest 18 F-florbetapir SUVR using cerebellar gray matter, white matter (two different segmentation masks), brainstem, and corpus callosum regions. Methods We calculated...
Short-term fall prediction models that use electronic health records (EHRs) may enable the implementation of dynamic care practices specifically address changes in individualized risk within senior facilities.The aim this study is to implement machine learning (ML) algorithms EHR data predict a 3-month residents from variety facilities providing different levels care.This retrospective obtained (2007-2021) Juniper Communities' proprietary database 2785 individuals primarily residing skilled...
We examined networks of tau connectivity between brain regions based on correlations their [18F]flortaucipir positron emission tomography (PET) uptake to evaluate sex-specific differences in brain-wide propagation.PET data clinically normal and mild cognitive impairment (MCI) subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were used examine network architectures across groups.The tau-based architecture resembled progression tauopathy Braak stage I VI regions. Compared...
We have designed a multi-pinhole collimator for dual-headed, stationary SPECT system that incorporates high-resolution silicon double-sided strip detectors. The compact camera design of our enables imaging at source–collimator distances between 20 and 30 mm. Our analytical calculations show using knife-edge pinholes with small-opening angles or cylindrically shaped in focused, configuration combination this geometry can generate narrow sensitivity profiles across the field view be useful...
The COVID-19 pandemic has affected people's lives beyond severe and long-term physical health symptoms. Social distancing quarantine have led to adverse mental outcomes. COVID-19-induced economic setbacks also likely exacerbated the psychological distress affecting broader aspects of well-being. Remote digital studies can provide information about pandemic's socioeconomic, mental, impact. COVIDsmart was a collaborative effort deploy complex research study understand impact on diverse...
Preclinical SPECT of rodents is both in demand and very demanding. The need for high spatial resolution combination with good sensitivity has given rise to considerable innovation the areas detectors, collimation, acquisition geometry, image reconstruction. Some developments described herein are beginning carry over into clinical imaging as well.
Current radiologic methods for diagnosing breast cancer detect specific morphologic features of solid tumors or any associated calcium deposits. These deposits originate from an early molecular microcalcification process 2 types: type 1 is oxylate and II carbonated hydroxyapatite. Type I microcalcifications are mainly with benign tumors, whereas produced internally by malignant cells. No current noninvasive in vivo techniques available detecting intratumoral microcalcifications. Such a...
Pulmonary embolism (PE) is a life-threatening condition associated with ~10% of deaths hospitalized patients. Machine learning algorithms (MLAs) which predict the onset pulmonary could enable earlier treatment and improve patient outcomes. However, extent to they generalize broader populations impacts their clinical utility.To conduct first large-scale external validation machine learning-based PE prediction model uses EHR data from three hours patient's hospital stay occurrence within next...
Silicon double-sided strip detectors offer outstanding instrinsic spatial resolution with reasonable detection efficiency for iodine-125 emissions. This allows multiple-pinhole imaging at low magnification, minimizing the problem of multiplexing. We have conducted studies using a prototype system that utilizes detector 300-micrometer thickness and 50-micrometer pitch together 23-pinhole collimator. These include an investigation synthetic-collimator approach, which combines projections...
Semi-quantitative image analysis methods in Alzheimer's Disease (AD) require normalization of positron emission tomography (PET) images. However, recent studies have found variabilities associated with reference region selection amyloid PET Haralick features (HFs) generated from the Gray Level Co-occurrence Matrix (GLCM) quantify spatial characteristics radiotracer uptake without need for intensity normalization. The objective this study is to calculate several HFs different diagnostic...
One of the most promising high resolution positron emission tomography detector designs comprises an array small, optically isolated scintillator crystals each coupled to independent photosensor, such as avalanche photodiode (APD). However, crosstalk between (due Compton scatter, photoelectron escape, or incomplete optical isolation) can significantly degrade performance and is expected increase become narrower improve spatial resolution. Various measures have been determined for different...
This work describes a fully 3D statistical image reconstruction for the RatCAP (Rat Conscious Animal PET) using Monte Carlo based system matrix. The consists of 12 Iutetium oxyorthosilicate (LSO)-avalanche photodiode (APD) detector blocks arranged in ring 41.2 mm diameter. Due to small diameter and low number total lines response (LORs), size complete matrix is comparison typical animal scanner. allows incorporation an accurate, RatCAP-specific physical model with inclusion crystal...
In younger adults, residual alterations in functional neural networks persist during remitted depression. However, there are fewer data for midlife and older adults at risk of recurrence. Such network may contribute to vulnerability This study examined intrinsic connectivity women with A total 69 (24 a history depression, 45 no psychiatric history) over 50 years age completed 3T fMRI resting-state acquisition. Participants depression met DSM-IV-TR criteria an episode the last 10 but not...
Abstract Objective: Menopause is associated with increasing cognitive complaints and older women are at increased risk of developing Alzheimer disease compared to men. However, there difficulty in early markers using objective performance measures. We investigated the impact subjective on cortical structure a sample younger postmenopausal women. Methods: Data for this cross-sectional study were drawn from baseline visit longer double-blind examining estrogen-cholinergic interactions normal...
Predicting biochemical recurrence of prostate cancer is imperative for initiating early treatment, which can improve the outcome treatment. However, because inter- and intrareader variability in interpretation F-18 fluciclovine positron emission tomography/computed tomography (PET/CT), it difficult to reliably discern between necrotic tissue owing radiation therapy tumor tissue. Our goal develop a computational methodology using Haralick texture analysis that be used as an adjunct tool...
We have performed a theoretical study to explore the potential and limitations of synthetic collimation for SPECT imaging with stacked-detector acquisition (dual magnification). This will be used optimize SiliSPECT, small-animal small volumes such as mouse brain at high sensitivity resolution. The enables image reconstruction limited number camera views in presence significant multiplexing. also developed new formulation quantify multiplexed object investigated how this changes different...
In pinhole single photon emission computed tomography (SPECT), multi-pinhole collimators can increase sensitivity but may lead to projection overlap, or multiplexing, which cause image artifacts. this work, we explore whether a stacked-detector configuration with germanium and silicon detector, used <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">123</sup> I (27-32, 159 keV), where little multiplexing occurs in the Si projections, reduce...
Abstract Background Prostate cancer (PCa) screening is not routinely conducted in men aged 55 and younger, although this age group accounts for more than 10% of cases. Polygenic risk scores (PRSs) patient data applied toward early prediction PCa may lead to earlier interventions increased survival. We have developed machine learning (ML) models predict under using PRSs combined with data. Methods a retrospective study on 91,106 male patients 35–55 the UK Biobank database. Five gradient...