A5082289456- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Treatment of Major Depression
- Dementia and Cognitive Impairment Research
- Aging and Gerontology Research
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Advanced MRI Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- High Altitude and Hypoxia
- Attention Deficit Hyperactivity Disorder
- Cognitive Abilities and Testing
- Health, Environment, Cognitive Aging
- Cardiac Health and Mental Health
- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Hemoglobin structure and function
- Chronic Disease Management Strategies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Veterinary Medicine and Surgery
- Alcohol Consumption and Health Effects
- Artificial Intelligence in Healthcare
- Neural and Behavioral Psychology Studies
Medizinische Hochschule Hannover
2025
Vanderbilt University Medical Center
2017-2022
Vanderbilt University
2018
Abstract Depression is associated with markers of accelerated aging, but it unclear how this relationship changes across the lifespan. We examined whether a brain-based measure aging differed between depressed and never-depressed subjects adult lifespan was related to cognitive performance disability. applied machine-learning approach that estimated brain age from structural MRI data in two cohorts, respectively 170 midlife adults 154 older enrolled studies common entry criteria. Both...
Background Late-life depression (LLD) is associated with a fragile antidepressant response and high recurrence risk. This study examined what measures predict in remitted LLD. Methods Individuals of age 60 years or older Diagnostic Statistical Manual - IV (DSM-IV) diagnosis major depressive disorder were enrolled the neurocognitive outcomes elderly study. Participants received manualized treatment followed longitudinally for an average 5 years. Study analyses included participants who...
Abstract Background and Aims Patients with left-ventricular-assist-devices (LVAD) are at high risk for ventricular tachycardia (VT), data on VT ablation in LVAD patients is scarce. This multicentre registry assessed the mechanism of VT, procedural parameters, outcome (NCT06063811). Methods Data referred 9 tertiary care centres were collected retrospectively. Parameters included mechanisms, data, recurrence, mortality. Results Overall, 69 (90% male, mean age 60.7±8.4 years) undergoing 72...
Cognitive complaints are common in depression, and cognition may be an important treatment target as cognitive problems often remain during remission contribute to recurrence risk. Previous studies of performance depression have mainly examined late-life with a focus on older adults, or assessed specific tasks rather than domains.This study across multiple domains antidepressant-free depressed adults early onset recurrent compared never-depressed controls. Domain scores were calculated for...
Late-life depression (LLD) is characterized by differences in resting state functional connectivity within and between intrinsic networks. This study examined whether clinical improvement to antidepressant medications associated with pre-randomization brain networks.Participants were 95 elders aged 60 years or older major depressive disorder. After assessments baseline MRI, participants randomized escitalopram placebo a two-to-one allocation for 8 weeks. Non-remitting subsequently entered an...
In younger adults, residual alterations in functional neural networks persist during remitted depression. However, there are fewer data for midlife and older adults at risk of recurrence. Such network may contribute to vulnerability This study examined intrinsic connectivity women with A total 69 (24 a history depression, 45 no psychiatric history) over 50 years age completed 3T fMRI resting-state acquisition. Participants depression met DSM-IV-TR criteria an episode the last 10 but not...
Increasing reliance on electronic medical records at large centers provides unique opportunities to perform population level analyses exploring disease progression and etiology. The massive accumulation of diagnostic, procedure, laboratory codes in one place has enabled the exploration co-occurring conditions, their risk factors, potential prognostic factors. While most readily identifiable associations are (now) well known scientific community, there is no doubt many more relationships...
Late-life depression (LLD) is a debilitating condition that associated with poor response to antidepressant medications and deficits in cognitive performance. Nicotinic cholinergic stimulation has emerged as potentially effective candidate improve performance patients impairment. Previous studies of nicotinic animal models human populations impairment led examining potential mood effects older adults LLD. We report results from pilot study transdermal nicotine LLD testing whether treatment...